Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization

Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization

Severe spinal cord injury (SCI) disrupts neuronal circulation and results in irreversible motor function loss. Treating SCI is a major challenge due to the limited regenerative capacity of axons and the inflammatory environment that hinders recovery. Macrophages play a dual role in SCI, with their p...

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Bibliographic Details
Main Authors: Jianshui Mao, Liangliang Chen, Genying Zhuang, Zhiqiang Jin, Shoukun Wu, Mingshuai Ying, Lingchao Sheng, Jianwei Lv, Qiuchen Bi, Jingjia Ye
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Macrophage polarization
Drug delivery
ROS response
Spinal cord injury
Wound healing
Immune reaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425004557
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