Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization
Severe spinal cord injury (SCI) disrupts neuronal circulation and results in irreversible motor function loss. Treating SCI is a major challenge due to the limited regenerative capacity of axons and the inflammatory environment that hinders recovery. Macrophages play a dual role in SCI, with their p...
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Elsevier
2025-06-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425004557 |
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| author | Jianshui Mao Liangliang Chen Genying Zhuang Zhiqiang Jin Shoukun Wu Mingshuai Ying Lingchao Sheng Jianwei Lv Qiuchen Bi Jingjia Ye |
| author_facet | Jianshui Mao Liangliang Chen Genying Zhuang Zhiqiang Jin Shoukun Wu Mingshuai Ying Lingchao Sheng Jianwei Lv Qiuchen Bi Jingjia Ye |
| author_sort | Jianshui Mao |
| collection | DOAJ |
| description | Severe spinal cord injury (SCI) disrupts neuronal circulation and results in irreversible motor function loss. Treating SCI is a major challenge due to the limited regenerative capacity of axons and the inflammatory environment that hinders recovery. Macrophages play a dual role in SCI, with their polarization determining whether they exacerbate the injury or promote tissue repair. In this study, we developed a curcumin-loaded polydopamine nanoparticle antioxidant scaffold (cur-PDA@gel) as a novel therapeutic approach for SCI. This scaffold was designed to bidirectionally modulate macrophage polarization. The polydopamine-coated nanoparticles demonstrated strong antioxidant activity, effectively neutralizing reactive oxygen species (ROS) and reducing inflammation. Curcumin released from the scaffold promoted M2-type macrophage polarization while inhibiting M1-type polarization, thereby reshaping the inflammatory microenvironment at the injury site and facilitating axonal regeneration. Mechanistically, curcumin regulated macrophage polarization by suppressing the NF-κB signaling pathway and activating the JAK/STAT pathway, particularly in the context of cur-PDA@gel implantation. These findings underscore the potential of cur-PDA@gel as a promising therapeutic strategy for SCI repair by targeting macrophage polarization. |
| format | Article |
| id | doaj-art-8d6b5f8659454c1e9742e6428ef70513 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| spelling | doaj-art-8d6b5f8659454c1e9742e6428ef705132025-08-20T03:48:27ZengElsevierMaterials Today Bio2590-00642025-06-013210189510.1016/j.mtbio.2025.101895Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarizationJianshui Mao0Liangliang Chen1Genying Zhuang2Zhiqiang Jin3Shoukun Wu4Mingshuai Ying5Lingchao Sheng6Jianwei Lv7Qiuchen Bi8Jingjia Ye9Department of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, China; Corresponding author.College of Computer Science and Technology, Zhejiang University, Hangzhou, 310000, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, China; College of Computer Science and Technology, Zhejiang University, Hangzhou, 310000, China; Center for Regenerative Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, China; Department of Stomatology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, ChinaCorresponding author.; Department of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, China; College of Computer Science and Technology, Zhejiang University, Hangzhou, 310000, China; Center for Regenerative Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, China; Department of Stomatology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, ChinaCorresponding author.; Department of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, China; College of Computer Science and Technology, Zhejiang University, Hangzhou, 310000, China; Center for Regenerative Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, China; Department of Stomatology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, ChinaSevere spinal cord injury (SCI) disrupts neuronal circulation and results in irreversible motor function loss. Treating SCI is a major challenge due to the limited regenerative capacity of axons and the inflammatory environment that hinders recovery. Macrophages play a dual role in SCI, with their polarization determining whether they exacerbate the injury or promote tissue repair. In this study, we developed a curcumin-loaded polydopamine nanoparticle antioxidant scaffold (cur-PDA@gel) as a novel therapeutic approach for SCI. This scaffold was designed to bidirectionally modulate macrophage polarization. The polydopamine-coated nanoparticles demonstrated strong antioxidant activity, effectively neutralizing reactive oxygen species (ROS) and reducing inflammation. Curcumin released from the scaffold promoted M2-type macrophage polarization while inhibiting M1-type polarization, thereby reshaping the inflammatory microenvironment at the injury site and facilitating axonal regeneration. Mechanistically, curcumin regulated macrophage polarization by suppressing the NF-κB signaling pathway and activating the JAK/STAT pathway, particularly in the context of cur-PDA@gel implantation. These findings underscore the potential of cur-PDA@gel as a promising therapeutic strategy for SCI repair by targeting macrophage polarization.http://www.sciencedirect.com/science/article/pii/S2590006425004557Macrophage polarizationDrug deliveryROS responseSpinal cord injuryWound healingImmune reaction |
| spellingShingle | Jianshui Mao Liangliang Chen Genying Zhuang Zhiqiang Jin Shoukun Wu Mingshuai Ying Lingchao Sheng Jianwei Lv Qiuchen Bi Jingjia Ye Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization Materials Today Bio Macrophage polarization Drug delivery ROS response Spinal cord injury Wound healing Immune reaction |
| title | Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization |
| title_full | Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization |
| title_fullStr | Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization |
| title_full_unstemmed | Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization |
| title_short | Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization |
| title_sort | curcumin loaded polydopamine nanoparticles based antioxidant scaffold promote spinal cord repair though dural regulation of macrophage polarization |
| topic | Macrophage polarization Drug delivery ROS response Spinal cord injury Wound healing Immune reaction |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425004557 |
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