Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022
IntroductionNorovirus is a key pathogen of acute gastroenteritis and poses a significant burden on both the economy and public health. This study focuses on continuous monitoring of norovirus in Shenzhen, China, from 2016 to 2022, aiming to analyze the epidemic characteristics and genetic diversity...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1593610/full |
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| author | Xin Wang Wanqiu Liu Wanqiu Liu Wanqiu Liu Mingda Hu Hui Ma Yaqing He Boqian Wang Kexin Li Kexin Li Kexin Li Rui Zhang Rui Zhang Rui Zhang JingJing Fu JingJing Fu Hailong Zhang Long Chen Xinru Zhao Xinru Zhao Xinru Zhao Buaijier Aimaiti Buaijier Aimaiti Buaijier Aimaiti Hongbin Song Hongguang Ren Xiaofeng Hu |
| author_facet | Xin Wang Wanqiu Liu Wanqiu Liu Wanqiu Liu Mingda Hu Hui Ma Yaqing He Boqian Wang Kexin Li Kexin Li Kexin Li Rui Zhang Rui Zhang Rui Zhang JingJing Fu JingJing Fu Hailong Zhang Long Chen Xinru Zhao Xinru Zhao Xinru Zhao Buaijier Aimaiti Buaijier Aimaiti Buaijier Aimaiti Hongbin Song Hongguang Ren Xiaofeng Hu |
| author_sort | Xin Wang |
| collection | DOAJ |
| description | IntroductionNorovirus is a key pathogen of acute gastroenteritis and poses a significant burden on both the economy and public health. This study focuses on continuous monitoring of norovirus in Shenzhen, China, from 2016 to 2022, aiming to analyze the epidemic characteristics and genetic diversity of norovirus in the context of global sequence data.MethodsThe study was based on data collected from local sentinel hospitals. It involved analyzing the demographic, spatial, and temporal distribution of norovirus infections. Phylogenetic analysis was conducted, and genotype dynamics were compared across geographic levels. Mutations affecting protein stability were evaluated, and recombination analysis was performed to identify critical breakpoints and fragments for norovirus.ResultsThe study found that norovirus primarily infected infants under 3 years old, with epidemics occurring in winter and concentrated in developed districts. Phylogenetic analysis revealed both similarities and differences in the evolutionary patterns of various genotypes at different geographical levels. Mutations in the VP1 protein, based on the protein structure of GII.4_Sydney[P31], provided insights into the evolutionary trends of key genotypes. Additionally, recombination analysis identified important breakpoints and fragments for norovirus.DiscussionThe findings offer valuable insights to evolution and transmission of norovirus. These results can serve as a reference for future research, and they may aid in vaccine development efforts aimed at controlling norovirus outbreaks. |
| format | Article |
| id | doaj-art-8d66d2095fc849d3a00d315b6cec2f4d |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-8d66d2095fc849d3a00d315b6cec2f4d2025-08-20T03:21:59ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-06-011510.3389/fcimb.2025.15936101593610Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022Xin Wang0Wanqiu Liu1Wanqiu Liu2Wanqiu Liu3Mingda Hu4Hui Ma5Yaqing He6Boqian Wang7Kexin Li8Kexin Li9Kexin Li10Rui Zhang11Rui Zhang12Rui Zhang13JingJing Fu14JingJing Fu15Hailong Zhang16Long Chen17Xinru Zhao18Xinru Zhao19Xinru Zhao20Buaijier Aimaiti21Buaijier Aimaiti22Buaijier Aimaiti23Hongbin Song24Hongguang Ren25Xiaofeng Hu26Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, ChinaLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, ChinaSchool of Public Health, University of South China, Hengyang, ChinaInstitute of Pathogen, Shenzhen Center for Disease Control and Prevention, Shenzhen, ChinaLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, ChinaNursing Department, PLA General Hospital, Beijing, ChinaInstitute of Pathogen, Shenzhen Center for Disease Control and Prevention, Shenzhen, ChinaLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, ChinaLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, ChinaHealth Supervision and Surveillance, Chinese People's Liberation Army (PLA) Center for Disease Control and Prevention, Beijing, ChinaSchool of Public Health, China Medical University, Shenyang, ChinaLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, ChinaHealth Supervision and Surveillance, Chinese People's Liberation Army (PLA) Center for Disease Control and Prevention, Beijing, ChinaSchool of Public Health, China Medical University, Shenyang, ChinaLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, ChinaSchool of Public Health,Southern Medical University, Guangzhou, ChinaInstitute of Pathogen, Shenzhen Center for Disease Control and Prevention, Shenzhen, ChinaInstitute of Pathogen, Shenzhen Center for Disease Control and Prevention, Shenzhen, ChinaLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, ChinaHealth Supervision and Surveillance, Chinese People's Liberation Army (PLA) Center for Disease Control and Prevention, Beijing, ChinaSchool of Public Health, China Medical University, Shenyang, ChinaLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, ChinaHealth Supervision and Surveillance, Chinese People's Liberation Army (PLA) Center for Disease Control and Prevention, Beijing, ChinaSchool of Public Health, China Medical University, Shenyang, ChinaHealth Supervision and Surveillance, Chinese People's Liberation Army (PLA) Center for Disease Control and Prevention, Beijing, ChinaLaboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, ChinaHealth Supervision and Surveillance, Chinese People's Liberation Army (PLA) Center for Disease Control and Prevention, Beijing, ChinaIntroductionNorovirus is a key pathogen of acute gastroenteritis and poses a significant burden on both the economy and public health. This study focuses on continuous monitoring of norovirus in Shenzhen, China, from 2016 to 2022, aiming to analyze the epidemic characteristics and genetic diversity of norovirus in the context of global sequence data.MethodsThe study was based on data collected from local sentinel hospitals. It involved analyzing the demographic, spatial, and temporal distribution of norovirus infections. Phylogenetic analysis was conducted, and genotype dynamics were compared across geographic levels. Mutations affecting protein stability were evaluated, and recombination analysis was performed to identify critical breakpoints and fragments for norovirus.ResultsThe study found that norovirus primarily infected infants under 3 years old, with epidemics occurring in winter and concentrated in developed districts. Phylogenetic analysis revealed both similarities and differences in the evolutionary patterns of various genotypes at different geographical levels. Mutations in the VP1 protein, based on the protein structure of GII.4_Sydney[P31], provided insights into the evolutionary trends of key genotypes. Additionally, recombination analysis identified important breakpoints and fragments for norovirus.DiscussionThe findings offer valuable insights to evolution and transmission of norovirus. These results can serve as a reference for future research, and they may aid in vaccine development efforts aimed at controlling norovirus outbreaks.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1593610/fullnorovirusgenetic diversitymutationrecombinationShenzhen |
| spellingShingle | Xin Wang Wanqiu Liu Wanqiu Liu Wanqiu Liu Mingda Hu Hui Ma Yaqing He Boqian Wang Kexin Li Kexin Li Kexin Li Rui Zhang Rui Zhang Rui Zhang JingJing Fu JingJing Fu Hailong Zhang Long Chen Xinru Zhao Xinru Zhao Xinru Zhao Buaijier Aimaiti Buaijier Aimaiti Buaijier Aimaiti Hongbin Song Hongguang Ren Xiaofeng Hu Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022 Frontiers in Cellular and Infection Microbiology norovirus genetic diversity mutation recombination Shenzhen |
| title | Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022 |
| title_full | Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022 |
| title_fullStr | Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022 |
| title_full_unstemmed | Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022 |
| title_short | Genetic diversity of norovirus in Shenzhen Based on continuous surveillance from 2016 to 2022 |
| title_sort | genetic diversity of norovirus in shenzhen based on continuous surveillance from 2016 to 2022 |
| topic | norovirus genetic diversity mutation recombination Shenzhen |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1593610/full |
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