Pericoronal Follicles of Asymptomatic Impacted Teeth: A Radiographic, Histomorphologic, and Immunohistochemical Study
Objective. To associate radiographic and histopathological features of pericoronal follicles (PFs) of asymptomatic impacted teeth and evaluate cell proliferation and apoptosis in the epithelium. Study Design. Epithelium and mesenchyme of radiographically normal (NPF≤2.5 mm) and hyperplastic (HPF 2.6...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2012/935310 |
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| author | Laura Villalba Federico Stolbizer Fabián Blasco Néstor Raúl Mauriño María Julia Piloni Alicia Keszler |
| author_facet | Laura Villalba Federico Stolbizer Fabián Blasco Néstor Raúl Mauriño María Julia Piloni Alicia Keszler |
| author_sort | Laura Villalba |
| collection | DOAJ |
| description | Objective. To associate radiographic and histopathological features of pericoronal follicles (PFs) of asymptomatic impacted teeth and evaluate cell proliferation and apoptosis in the epithelium. Study Design. Epithelium and mesenchyme of radiographically normal (NPF≤2.5 mm) and hyperplastic (HPF 2.6 to 5 mm) PF (n=140) were studied histologically. Cell proliferation (PI) and epithelial apoptosis were evaluated by Ki-67 and bcl-2 expression in 14 NPFs and 10 dentigerous cysts (DCs). Results. Radiographically, 127 were NPFs and 13 were HPFs; 87.8% of total PFs exhibited epithelium on the surface. Reduced enamel epithelium was observed in 78 (61.4%) NPFs and 6 (46.2%) HPFs, squamous metaplasia in 17 (13.4%) NPFs and 4 (30.8%) HPFs, and cystic epithelium in 15 (11.8%) NPFs and 3 (23%) HPFs. Mean PI was 1.97±1.25 and 7.97±1.74 in the epithelial component of NPF and DC, respectively; bcl-2 positive expression was observed in 9 (64.3%) NPFs and 7 (70%) DCs. Conclusion. The scant epithelial remnant proliferation could imply low risk for development of odontogenic pathologies in the absence of an additional stimulus. |
| format | Article |
| id | doaj-art-8d64315e918b4c7dbaf63960101d63e2 |
| institution | OA Journals |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-8d64315e918b4c7dbaf63960101d63e22025-08-20T02:09:41ZengWileyInternational Journal of Dentistry1687-87281687-87362012-01-01201210.1155/2012/935310935310Pericoronal Follicles of Asymptomatic Impacted Teeth: A Radiographic, Histomorphologic, and Immunohistochemical StudyLaura Villalba0Federico Stolbizer1Fabián Blasco2Néstor Raúl Mauriño3María Julia Piloni4Alicia Keszler5Department of Oral Pathology, School of Dentistry, University of Buenos Aires, 1122 Buenos Aires, ArgentinaDepartment of Buccomaxillofacial Surgery and Traumatology, School of Dentistry, University of Buenos Aires, 1122 Buenos Aires, ArgentinaDepartment of Buccomaxillofacial Surgery and Traumatology, School of Dentistry, University of Buenos Aires, 1122 Buenos Aires, ArgentinaDepartment of Buccomaxillofacial Surgery and Traumatology, School of Dentistry, University of Buenos Aires, 1122 Buenos Aires, ArgentinaDepartment of Oral Pathology, School of Dentistry, University of Buenos Aires, 1122 Buenos Aires, ArgentinaDepartment of Oral Pathology, School of Dentistry, University of Buenos Aires, 1122 Buenos Aires, ArgentinaObjective. To associate radiographic and histopathological features of pericoronal follicles (PFs) of asymptomatic impacted teeth and evaluate cell proliferation and apoptosis in the epithelium. Study Design. Epithelium and mesenchyme of radiographically normal (NPF≤2.5 mm) and hyperplastic (HPF 2.6 to 5 mm) PF (n=140) were studied histologically. Cell proliferation (PI) and epithelial apoptosis were evaluated by Ki-67 and bcl-2 expression in 14 NPFs and 10 dentigerous cysts (DCs). Results. Radiographically, 127 were NPFs and 13 were HPFs; 87.8% of total PFs exhibited epithelium on the surface. Reduced enamel epithelium was observed in 78 (61.4%) NPFs and 6 (46.2%) HPFs, squamous metaplasia in 17 (13.4%) NPFs and 4 (30.8%) HPFs, and cystic epithelium in 15 (11.8%) NPFs and 3 (23%) HPFs. Mean PI was 1.97±1.25 and 7.97±1.74 in the epithelial component of NPF and DC, respectively; bcl-2 positive expression was observed in 9 (64.3%) NPFs and 7 (70%) DCs. Conclusion. The scant epithelial remnant proliferation could imply low risk for development of odontogenic pathologies in the absence of an additional stimulus.http://dx.doi.org/10.1155/2012/935310 |
| spellingShingle | Laura Villalba Federico Stolbizer Fabián Blasco Néstor Raúl Mauriño María Julia Piloni Alicia Keszler Pericoronal Follicles of Asymptomatic Impacted Teeth: A Radiographic, Histomorphologic, and Immunohistochemical Study International Journal of Dentistry |
| title | Pericoronal Follicles of Asymptomatic Impacted Teeth: A Radiographic, Histomorphologic, and Immunohistochemical Study |
| title_full | Pericoronal Follicles of Asymptomatic Impacted Teeth: A Radiographic, Histomorphologic, and Immunohistochemical Study |
| title_fullStr | Pericoronal Follicles of Asymptomatic Impacted Teeth: A Radiographic, Histomorphologic, and Immunohistochemical Study |
| title_full_unstemmed | Pericoronal Follicles of Asymptomatic Impacted Teeth: A Radiographic, Histomorphologic, and Immunohistochemical Study |
| title_short | Pericoronal Follicles of Asymptomatic Impacted Teeth: A Radiographic, Histomorphologic, and Immunohistochemical Study |
| title_sort | pericoronal follicles of asymptomatic impacted teeth a radiographic histomorphologic and immunohistochemical study |
| url | http://dx.doi.org/10.1155/2012/935310 |
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