Delayed Malaria Recrudescence and Relapse in the Setting of COVID-19
It is unknown whether COVID-19 can trigger malaria recrudescence or relapse. Although Plasmodium falciparum recrudescence occurring years after infection is extremely rare, delayed Plasmodium vivax and Plasmodium ovale relapse from the latent hypnozoite stage is well described. We report a case of a...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2023-05-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.1034 |
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| author | Katherine Reifler Sonja Kytomaa Nancy S. Miller Daniel Bourque |
| author_facet | Katherine Reifler Sonja Kytomaa Nancy S. Miller Daniel Bourque |
| author_sort | Katherine Reifler |
| collection | DOAJ |
| description | It is unknown whether COVID-19 can trigger malaria recrudescence or relapse. Although Plasmodium falciparum recrudescence occurring years after infection is extremely rare, delayed Plasmodium vivax and Plasmodium ovale relapse from the latent hypnozoite stage is well described. We report a case of acute P falciparum and P ovale co-infection that occurred 2 weeks after COVID-19 in an otherwise immunocompetent patient living in a malaria nonendemic country and without exposure to malaria in the preceding 5 years. This case highlights a potential mechanism by which COVID-19–associated immune depletion and/or dysregulation may trigger a delayed presentation of malaria. |
| format | Article |
| id | doaj-art-8d62dad53acb4cccaa4fa4f507a3b602 |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-8d62dad53acb4cccaa4fa4f507a3b6022025-08-20T03:18:46ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642023-05-012510.7326/aimcc.2022.1034Delayed Malaria Recrudescence and Relapse in the Setting of COVID-19Katherine Reifler0Sonja Kytomaa1Nancy S. Miller2Daniel Bourque31Section of Infectious Disease, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts2Boston University School of Medicine, Boston, Massachusetts3Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts1Section of Infectious Disease, Department of Medicine, Boston University School of Medicine, Boston, MassachusettsIt is unknown whether COVID-19 can trigger malaria recrudescence or relapse. Although Plasmodium falciparum recrudescence occurring years after infection is extremely rare, delayed Plasmodium vivax and Plasmodium ovale relapse from the latent hypnozoite stage is well described. We report a case of acute P falciparum and P ovale co-infection that occurred 2 weeks after COVID-19 in an otherwise immunocompetent patient living in a malaria nonendemic country and without exposure to malaria in the preceding 5 years. This case highlights a potential mechanism by which COVID-19–associated immune depletion and/or dysregulation may trigger a delayed presentation of malaria.https://www.acpjournals.org/doi/10.7326/aimcc.2022.1034 |
| spellingShingle | Katherine Reifler Sonja Kytomaa Nancy S. Miller Daniel Bourque Delayed Malaria Recrudescence and Relapse in the Setting of COVID-19 Annals of Internal Medicine: Clinical Cases |
| title | Delayed Malaria Recrudescence and Relapse in the Setting of COVID-19 |
| title_full | Delayed Malaria Recrudescence and Relapse in the Setting of COVID-19 |
| title_fullStr | Delayed Malaria Recrudescence and Relapse in the Setting of COVID-19 |
| title_full_unstemmed | Delayed Malaria Recrudescence and Relapse in the Setting of COVID-19 |
| title_short | Delayed Malaria Recrudescence and Relapse in the Setting of COVID-19 |
| title_sort | delayed malaria recrudescence and relapse in the setting of covid 19 |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.1034 |
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