The role of epigenetic regulation in pancreatic ductal adenocarcinoma progression and drug response: an integrative genomic and pharmacological prognostic prediction model

The role of epigenetic regulation in pancreatic ductal adenocarcinoma progression and drug response: an integrative genomic and pharmacological prognostic prediction model

BackgroundPancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with poor prognosis. Epigenetic dysregulation plays a crucial role in PDAC progression, but its comprehensive landscape and clinical implications remain unclear.MethodsWe integrated single-cell RNA sequencing, bulk RNA s...

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Bibliographic Details
Main Authors: Kang Fu, Junzhe Su, Yiming Zhou, Xiaotong Chen, Xiao Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
pancreatic ductal adenocarcinoma
epigenetic regulation
single-cell RNA sequencing
machine learning
prognostic model
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1498031/full
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