Positively charged cytoplasmic residues in corin prevent signal peptidase cleavage and endoplasmic reticulum retention

Positively charged cytoplasmic residues in corin prevent signal peptidase cleavage and endoplasmic reticulum retention

Abstract Positively charged residues are commonly located near the cytoplasm-membrane interface, which is known as the positive-inside rule in membrane topology. The mechanism underlying the function of these charged residues remains poorly understood. Herein, we studied the function of cytoplasmic...

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Bibliographic Details
Main Authors: Hui Li, Shijin Sun, Wenjun Guo, Lina Wang, Zihao Zhang, Yue Zhang, Ce Zhang, Meng Liu, Shengnan Zhang, Yayan Niu, Ningzheng Dong, Qingyu Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07545-7
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