Human papillomavirus negative cervical cancers and precancerous lesions: prevalence, pathological and molecular features, and clinical implications
Background: Cervical cancer is the fourth most common cancer in women globally. Although human papillomavirus (HPV) testing plays an increasing role in cervical cancer screening and treatment, HPV-negative cervical cancer remains a consistently reported entity globally. While numerous studies have f...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-02-01
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| Series: | Gynecology and Obstetrics Clinical Medicine |
| Online Access: | https://gocm.bmj.com/content/5/1/e000160.full |
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| author | Liron Pantanowitz Chengquan Zhao Xianxu Zeng Wenli Dai |
| author_facet | Liron Pantanowitz Chengquan Zhao Xianxu Zeng Wenli Dai |
| author_sort | Liron Pantanowitz |
| collection | DOAJ |
| description | Background: Cervical cancer is the fourth most common cancer in women globally. Although human papillomavirus (HPV) testing plays an increasing role in cervical cancer screening and treatment, HPV-negative cervical cancer remains a consistently reported entity globally. While numerous studies have focused on HPV-positive cervical cancers, detailed studies on HPV-negative counterparts remain limited.Results: This literature review aims to discuss several aspects of HPV-negative cervical cancers including the prevalence of HPV-negative cervical carcinomas and precancerous lesions and their relation to sample types (paraffin-embedded tissue blocks or liquid samples). Additionally, we explore possible reasons for false HPV-negative cases. Furthermore, we review histomorphological, molecular and clinical features of HPV-negative cervical cancers.Conclusions: The topic of HPV-negative cervical cancers is of importance given the drive towards HPV primary screening, initiation of self-collected HPV testing and widespread use of HPV vaccination. |
| format | Article |
| id | doaj-art-8d5acee15f3a45fca5be496c88693af1 |
| institution | OA Journals |
| issn | 2097-0587 2667-1646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Gynecology and Obstetrics Clinical Medicine |
| spelling | doaj-art-8d5acee15f3a45fca5be496c88693af12025-08-20T01:51:41ZengBMJ Publishing GroupGynecology and Obstetrics Clinical Medicine2097-05872667-16462025-02-015110.1136/gocm-2024-000160Human papillomavirus negative cervical cancers and precancerous lesions: prevalence, pathological and molecular features, and clinical implicationsLiron Pantanowitz0Chengquan Zhao1Xianxu Zeng2Wenli Dai31 Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2 Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA4 Department of Pathology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China1 Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USABackground: Cervical cancer is the fourth most common cancer in women globally. Although human papillomavirus (HPV) testing plays an increasing role in cervical cancer screening and treatment, HPV-negative cervical cancer remains a consistently reported entity globally. While numerous studies have focused on HPV-positive cervical cancers, detailed studies on HPV-negative counterparts remain limited.Results: This literature review aims to discuss several aspects of HPV-negative cervical cancers including the prevalence of HPV-negative cervical carcinomas and precancerous lesions and their relation to sample types (paraffin-embedded tissue blocks or liquid samples). Additionally, we explore possible reasons for false HPV-negative cases. Furthermore, we review histomorphological, molecular and clinical features of HPV-negative cervical cancers.Conclusions: The topic of HPV-negative cervical cancers is of importance given the drive towards HPV primary screening, initiation of self-collected HPV testing and widespread use of HPV vaccination.https://gocm.bmj.com/content/5/1/e000160.full |
| spellingShingle | Liron Pantanowitz Chengquan Zhao Xianxu Zeng Wenli Dai Human papillomavirus negative cervical cancers and precancerous lesions: prevalence, pathological and molecular features, and clinical implications Gynecology and Obstetrics Clinical Medicine |
| title | Human papillomavirus negative cervical cancers and precancerous lesions: prevalence, pathological and molecular features, and clinical implications |
| title_full | Human papillomavirus negative cervical cancers and precancerous lesions: prevalence, pathological and molecular features, and clinical implications |
| title_fullStr | Human papillomavirus negative cervical cancers and precancerous lesions: prevalence, pathological and molecular features, and clinical implications |
| title_full_unstemmed | Human papillomavirus negative cervical cancers and precancerous lesions: prevalence, pathological and molecular features, and clinical implications |
| title_short | Human papillomavirus negative cervical cancers and precancerous lesions: prevalence, pathological and molecular features, and clinical implications |
| title_sort | human papillomavirus negative cervical cancers and precancerous lesions prevalence pathological and molecular features and clinical implications |
| url | https://gocm.bmj.com/content/5/1/e000160.full |
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