Human papillomavirus negative cervical cancers and precancerous lesions: prevalence, pathological and molecular features, and clinical implications
Background: Cervical cancer is the fourth most common cancer in women globally. Although human papillomavirus (HPV) testing plays an increasing role in cervical cancer screening and treatment, HPV-negative cervical cancer remains a consistently reported entity globally. While numerous studies have f...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2025-02-01
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| Series: | Gynecology and Obstetrics Clinical Medicine |
| Online Access: | https://gocm.bmj.com/content/5/1/e000160.full |
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| Summary: | Background: Cervical cancer is the fourth most common cancer in women globally. Although human papillomavirus (HPV) testing plays an increasing role in cervical cancer screening and treatment, HPV-negative cervical cancer remains a consistently reported entity globally. While numerous studies have focused on HPV-positive cervical cancers, detailed studies on HPV-negative counterparts remain limited.Results: This literature review aims to discuss several aspects of HPV-negative cervical cancers including the prevalence of HPV-negative cervical carcinomas and precancerous lesions and their relation to sample types (paraffin-embedded tissue blocks or liquid samples). Additionally, we explore possible reasons for false HPV-negative cases. Furthermore, we review histomorphological, molecular and clinical features of HPV-negative cervical cancers.Conclusions: The topic of HPV-negative cervical cancers is of importance given the drive towards HPV primary screening, initiation of self-collected HPV testing and widespread use of HPV vaccination. |
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| ISSN: | 2097-0587 2667-1646 |