Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature
Cryopyrin-associated periodic syndrome is a rare autoinflammatory syndrome caused by a dysregulation of cytokine signaling pathways, particularly of the interleukin-1β production. Symptoms typical appear early in life and include recurrent fever, arthralgia, and cutaneous rash, often accompanied by...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1591234/full |
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| author | Marta Salas Sánchez Elena García-Martínez Elena García-Martínez Héctor Balastegui Martín María Esther Durán-García María Esther Durán-García Cristina Lavilla Olleros Cristina Lavilla Olleros |
| author_facet | Marta Salas Sánchez Elena García-Martínez Elena García-Martínez Héctor Balastegui Martín María Esther Durán-García María Esther Durán-García Cristina Lavilla Olleros Cristina Lavilla Olleros |
| author_sort | Marta Salas Sánchez |
| collection | DOAJ |
| description | Cryopyrin-associated periodic syndrome is a rare autoinflammatory syndrome caused by a dysregulation of cytokine signaling pathways, particularly of the interleukin-1β production. Symptoms typical appear early in life and include recurrent fever, arthralgia, and cutaneous rash, often accompanied by systemic manifestations and progressive end-organ damage resulting from chronic inflammation. Interleukin- targeted therapy constitutes the basis for treatment, and can lead to complete resolution of symptoms. We report a case of a 66-year-old man with cryopyrin-associated periodic syndrome related to V198M mutation, successfully treated with anakinra, an interleukin- 1 inhibitor frequently used in rheumatoid arthritis. |
| format | Article |
| id | doaj-art-8d5aab2fb8d840cfa6abb02cb0d16e2a |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-8d5aab2fb8d840cfa6abb02cb0d16e2a2025-08-20T02:32:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15912341591234Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literatureMarta Salas Sánchez0Elena García-Martínez1Elena García-Martínez2Héctor Balastegui Martín3María Esther Durán-García4María Esther Durán-García5Cristina Lavilla Olleros6Cristina Lavilla Olleros7Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, SpainImmunology Department, Hospital General Universitario Gregorio Marañón, Madrid, SpainInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, SpainPrimary Immunodeficiencies Unit, Hospital Universitario y Politécnico La Fe, Valencia, SpainInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, SpainPharmacy Department, Hospital General Universitario Gregorio Marañó, Madrid, SpainDepartment of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, SpainInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, SpainCryopyrin-associated periodic syndrome is a rare autoinflammatory syndrome caused by a dysregulation of cytokine signaling pathways, particularly of the interleukin-1β production. Symptoms typical appear early in life and include recurrent fever, arthralgia, and cutaneous rash, often accompanied by systemic manifestations and progressive end-organ damage resulting from chronic inflammation. Interleukin- targeted therapy constitutes the basis for treatment, and can lead to complete resolution of symptoms. We report a case of a 66-year-old man with cryopyrin-associated periodic syndrome related to V198M mutation, successfully treated with anakinra, an interleukin- 1 inhibitor frequently used in rheumatoid arthritis.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1591234/fullcryopyrin-associated periodic syndromeCAPSautoinflammatory diseaseanakinracase report |
| spellingShingle | Marta Salas Sánchez Elena García-Martínez Elena García-Martínez Héctor Balastegui Martín María Esther Durán-García María Esther Durán-García Cristina Lavilla Olleros Cristina Lavilla Olleros Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature Frontiers in Immunology cryopyrin-associated periodic syndrome CAPS autoinflammatory disease anakinra case report |
| title | Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature |
| title_full | Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature |
| title_fullStr | Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature |
| title_full_unstemmed | Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature |
| title_short | Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature |
| title_sort | use of anakinra in cryopyrin associated periodic syndromes case report and review of literature |
| topic | cryopyrin-associated periodic syndrome CAPS autoinflammatory disease anakinra case report |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1591234/full |
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