Impact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort study
Abstract Background Triglyceride-glucose (TyG) index was regarded as a cost-efficient and reliable clinical surrogate marker for insulin resistance (IR), which was significantly correlated with cardiovascular disease (CVD). However, the TyG index and incident CVD in non-diabetic hypertension patient...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-025-21522-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585297870716928 |
|---|---|
| author | Xin Chen Jinyou Yang Dan Wang Jiali Liu Hang Jin Yongqing Zhang Quanyong Xiang |
| author_facet | Xin Chen Jinyou Yang Dan Wang Jiali Liu Hang Jin Yongqing Zhang Quanyong Xiang |
| author_sort | Xin Chen |
| collection | DOAJ |
| description | Abstract Background Triglyceride-glucose (TyG) index was regarded as a cost-efficient and reliable clinical surrogate marker for insulin resistance (IR), which was significantly correlated with cardiovascular disease (CVD). However, the TyG index and incident CVD in non-diabetic hypertension patients remains uncertain. The aim of study was to explore the impact of TyG index level and variability on risk of CVD among non-diabetic hypertension patients. Methods A total of 9313 hypertensive patients without diabetes aged 30–70 years in Jiangsu Province who participated in the baseline survey from January 2010 to December 2010 and were followed up to May 2020 were included in this study. The TyG index was calculated as ln [fasting triglyceride (TG) (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2] and variation degree was calculated as the TyG index at first year follow-up (2011) minus that at baseline (2010). Cox proportional analysis regression and restricted cubic spline were used to investigate the association between TyG index level as well as variability and CVD risk. Results Of 9313 included participants, 5423(58.23%) were female. During a mean follow-up of 8.32 ± 1.43 years, 890(9.56%) CVD events was identified. Cox regression analysis showed that with the highest TyG index in Q4 group at baseline, the incidence of CVD risk increased by 33.6% after adjustment for multiple confounders compared to Q1 group. Compared with TyG index variation degree 0 ~ < 1, the hazard ratios (HR) and 95% confidence interval (CI) respectively in < 0, 1 ~ < 2 and 2 ~ were 0.326(0.276, 0.384), 3.216(2.697,3.835) and 4.225(3.359,5.314). The restricted cubic spline indicated that there was a non-linear dose-response relationship between the change degree of TyG and risk of CVD. Similar results were obtained by subgroup analysis and sensitivity analysis. Conclusion Elevated TyG index may be used as a surrogate for IR and help optimize risk stratification of CVD as well as prevention and management. |
| format | Article |
| id | doaj-art-8d571bcc9a704139a83e71d6c12a8368 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-8d571bcc9a704139a83e71d6c12a83682025-01-26T12:55:40ZengBMCBMC Public Health1471-24582025-01-0125111010.1186/s12889-025-21522-zImpact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort studyXin Chen0Jinyou Yang1Dan Wang2Jiali Liu3Hang Jin4Yongqing Zhang5Quanyong Xiang6School of Public Health, Southeast UniversityDepartment of Health and Rehabilitation, Jiangsu College of NursingSchool of Public Health, Southeast UniversitySchool of Public Health, Southeast UniversitySchool of Public Health, Southeast UniversityDepartment of Chronic Non-Communicable Disease Control, Jiangsu Provincial Center for Disease Control and PreventionSchool of Public Health, Southeast UniversityAbstract Background Triglyceride-glucose (TyG) index was regarded as a cost-efficient and reliable clinical surrogate marker for insulin resistance (IR), which was significantly correlated with cardiovascular disease (CVD). However, the TyG index and incident CVD in non-diabetic hypertension patients remains uncertain. The aim of study was to explore the impact of TyG index level and variability on risk of CVD among non-diabetic hypertension patients. Methods A total of 9313 hypertensive patients without diabetes aged 30–70 years in Jiangsu Province who participated in the baseline survey from January 2010 to December 2010 and were followed up to May 2020 were included in this study. The TyG index was calculated as ln [fasting triglyceride (TG) (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2] and variation degree was calculated as the TyG index at first year follow-up (2011) minus that at baseline (2010). Cox proportional analysis regression and restricted cubic spline were used to investigate the association between TyG index level as well as variability and CVD risk. Results Of 9313 included participants, 5423(58.23%) were female. During a mean follow-up of 8.32 ± 1.43 years, 890(9.56%) CVD events was identified. Cox regression analysis showed that with the highest TyG index in Q4 group at baseline, the incidence of CVD risk increased by 33.6% after adjustment for multiple confounders compared to Q1 group. Compared with TyG index variation degree 0 ~ < 1, the hazard ratios (HR) and 95% confidence interval (CI) respectively in < 0, 1 ~ < 2 and 2 ~ were 0.326(0.276, 0.384), 3.216(2.697,3.835) and 4.225(3.359,5.314). The restricted cubic spline indicated that there was a non-linear dose-response relationship between the change degree of TyG and risk of CVD. Similar results were obtained by subgroup analysis and sensitivity analysis. Conclusion Elevated TyG index may be used as a surrogate for IR and help optimize risk stratification of CVD as well as prevention and management.https://doi.org/10.1186/s12889-025-21522-zTriglyceride-glucose indexCardiovascular diseaseHypertension patientsDisease preventionCohort study |
| spellingShingle | Xin Chen Jinyou Yang Dan Wang Jiali Liu Hang Jin Yongqing Zhang Quanyong Xiang Impact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort study BMC Public Health Triglyceride-glucose index Cardiovascular disease Hypertension patients Disease prevention Cohort study |
| title | Impact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort study |
| title_full | Impact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort study |
| title_fullStr | Impact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort study |
| title_full_unstemmed | Impact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort study |
| title_short | Impact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort study |
| title_sort | impact of triglyceride glucose index on risk of cardiovascular disease among non diabetic hypertension patients a 10 year prospective cohort study |
| topic | Triglyceride-glucose index Cardiovascular disease Hypertension patients Disease prevention Cohort study |
| url | https://doi.org/10.1186/s12889-025-21522-z |
| work_keys_str_mv | AT xinchen impactoftriglycerideglucoseindexonriskofcardiovasculardiseaseamongnondiabetichypertensionpatientsa10yearprospectivecohortstudy AT jinyouyang impactoftriglycerideglucoseindexonriskofcardiovasculardiseaseamongnondiabetichypertensionpatientsa10yearprospectivecohortstudy AT danwang impactoftriglycerideglucoseindexonriskofcardiovasculardiseaseamongnondiabetichypertensionpatientsa10yearprospectivecohortstudy AT jialiliu impactoftriglycerideglucoseindexonriskofcardiovasculardiseaseamongnondiabetichypertensionpatientsa10yearprospectivecohortstudy AT hangjin impactoftriglycerideglucoseindexonriskofcardiovasculardiseaseamongnondiabetichypertensionpatientsa10yearprospectivecohortstudy AT yongqingzhang impactoftriglycerideglucoseindexonriskofcardiovasculardiseaseamongnondiabetichypertensionpatientsa10yearprospectivecohortstudy AT quanyongxiang impactoftriglycerideglucoseindexonriskofcardiovasculardiseaseamongnondiabetichypertensionpatientsa10yearprospectivecohortstudy |