Lung Cancer Associated with Neurofibromatosis Type I
Lung cancer associated with neurofibromatosis type I is considered very rare, and only a few case reports have been described in the literature. There is some evidence that a genetic linkage between neurofibromatosis and carcinogenesis in the lung may exist. We present a 42-year-old female, lifetime...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Radiology |
| Online Access: | http://dx.doi.org/10.1155/2013/869793 |
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| _version_ | 1832545588981268480 |
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| author | Anastasia Oikonomou Dimitrios Mikroulis Paraskevi Mintzopoulou Lawal Lukman Panos Prassopoulos |
| author_facet | Anastasia Oikonomou Dimitrios Mikroulis Paraskevi Mintzopoulou Lawal Lukman Panos Prassopoulos |
| author_sort | Anastasia Oikonomou |
| collection | DOAJ |
| description | Lung cancer associated with neurofibromatosis type I is considered very rare, and only a few case reports have been described in the literature. There is some evidence that a genetic linkage between neurofibromatosis and carcinogenesis in the lung may exist. We present a 42-year-old female, lifetime nonsmoker with a known history of neurofibromatosis type I, free of respiratory symptoms, who underwent a low-dose HRCT of the lungs to investigate any occult interstitial lung changes. A solitary ill-defined nodule of a ground-glass opacity was detected incidentally in the middle lobe with no associated lymphadenopathy or metastatic disease. Several thin-walled lung cysts were also seen in the lower lobes. Histological analysis of the nodule after middle lobectomy revealed well-differentiated adenocarcinoma. The patient did not receive systemic chemotherapy or radiotherapy. She was free of disease on 18-month followup. |
| format | Article |
| id | doaj-art-8d559bb1135845c6adafdf54928ce37d |
| institution | Kabale University |
| issn | 2090-6862 2090-6870 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Radiology |
| spelling | doaj-art-8d559bb1135845c6adafdf54928ce37d2025-02-03T07:25:20ZengWileyCase Reports in Radiology2090-68622090-68702013-01-01201310.1155/2013/869793869793Lung Cancer Associated with Neurofibromatosis Type IAnastasia Oikonomou0Dimitrios Mikroulis1Paraskevi Mintzopoulou2Lawal Lukman3Panos Prassopoulos4Department of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Cardiothoracic Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Cardiothoracic Surgery, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, GreeceLung cancer associated with neurofibromatosis type I is considered very rare, and only a few case reports have been described in the literature. There is some evidence that a genetic linkage between neurofibromatosis and carcinogenesis in the lung may exist. We present a 42-year-old female, lifetime nonsmoker with a known history of neurofibromatosis type I, free of respiratory symptoms, who underwent a low-dose HRCT of the lungs to investigate any occult interstitial lung changes. A solitary ill-defined nodule of a ground-glass opacity was detected incidentally in the middle lobe with no associated lymphadenopathy or metastatic disease. Several thin-walled lung cysts were also seen in the lower lobes. Histological analysis of the nodule after middle lobectomy revealed well-differentiated adenocarcinoma. The patient did not receive systemic chemotherapy or radiotherapy. She was free of disease on 18-month followup.http://dx.doi.org/10.1155/2013/869793 |
| spellingShingle | Anastasia Oikonomou Dimitrios Mikroulis Paraskevi Mintzopoulou Lawal Lukman Panos Prassopoulos Lung Cancer Associated with Neurofibromatosis Type I Case Reports in Radiology |
| title | Lung Cancer Associated with Neurofibromatosis Type I |
| title_full | Lung Cancer Associated with Neurofibromatosis Type I |
| title_fullStr | Lung Cancer Associated with Neurofibromatosis Type I |
| title_full_unstemmed | Lung Cancer Associated with Neurofibromatosis Type I |
| title_short | Lung Cancer Associated with Neurofibromatosis Type I |
| title_sort | lung cancer associated with neurofibromatosis type i |
| url | http://dx.doi.org/10.1155/2013/869793 |
| work_keys_str_mv | AT anastasiaoikonomou lungcancerassociatedwithneurofibromatosistypei AT dimitriosmikroulis lungcancerassociatedwithneurofibromatosistypei AT paraskevimintzopoulou lungcancerassociatedwithneurofibromatosistypei AT lawallukman lungcancerassociatedwithneurofibromatosistypei AT panosprassopoulos lungcancerassociatedwithneurofibromatosistypei |