Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain.
It was recently suggested that supplying the brain with new neurons could counteract Alzheimer's disease (AD). This provocative idea requires further testing in experimental models in which the molecular basis of disease-induced neuronal regeneration could be investigated. We previously found t...
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000585&type=printable |
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| author | Prabesh Bhattarai Mehmet Ilyas Cosacak Violeta Mashkaryan Sevgican Demir Stanislava Dimitrova Popova Nambirajan Govindarajan Kerstin Brandt Yixin Zhang Weipang Chang Konstantinos Ampatzis Caghan Kizil |
| author_facet | Prabesh Bhattarai Mehmet Ilyas Cosacak Violeta Mashkaryan Sevgican Demir Stanislava Dimitrova Popova Nambirajan Govindarajan Kerstin Brandt Yixin Zhang Weipang Chang Konstantinos Ampatzis Caghan Kizil |
| author_sort | Prabesh Bhattarai |
| collection | DOAJ |
| description | It was recently suggested that supplying the brain with new neurons could counteract Alzheimer's disease (AD). This provocative idea requires further testing in experimental models in which the molecular basis of disease-induced neuronal regeneration could be investigated. We previously found that zebrafish stimulates neural stem cell (NSC) plasticity and neurogenesis in AD and could help to understand the mechanisms to be harnessed for developing new neurons in diseased mammalian brains. Here, by performing single-cell transcriptomics, we found that amyloid toxicity-induced interleukin-4 (IL4) promotes NSC proliferation and neurogenesis by suppressing the tryptophan metabolism and reducing the production of serotonin. NSC proliferation was suppressed by serotonin via down-regulation of brain-derived neurotrophic factor (BDNF)-expression in serotonin-responsive periventricular neurons. BDNF enhances NSC plasticity and neurogenesis via nerve growth factor receptor A (NGFRA)/ nuclear factor 'kappa-light-chain-enhancer' of activated B-cells (NFkB) signaling in zebrafish but not in rodents. Collectively, our results suggest a complex neuron-glia interaction that regulates regenerative neurogenesis after AD conditions in zebrafish. |
| format | Article |
| id | doaj-art-8d5216d5f4864241a8d4ccbdf3cf52d2 |
| institution | DOAJ |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-8d5216d5f4864241a8d4ccbdf3cf52d22025-08-20T02:55:20ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852020-01-01181e300058510.1371/journal.pbio.3000585Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain.Prabesh BhattaraiMehmet Ilyas CosacakVioleta MashkaryanSevgican DemirStanislava Dimitrova PopovaNambirajan GovindarajanKerstin BrandtYixin ZhangWeipang ChangKonstantinos AmpatzisCaghan KizilIt was recently suggested that supplying the brain with new neurons could counteract Alzheimer's disease (AD). This provocative idea requires further testing in experimental models in which the molecular basis of disease-induced neuronal regeneration could be investigated. We previously found that zebrafish stimulates neural stem cell (NSC) plasticity and neurogenesis in AD and could help to understand the mechanisms to be harnessed for developing new neurons in diseased mammalian brains. Here, by performing single-cell transcriptomics, we found that amyloid toxicity-induced interleukin-4 (IL4) promotes NSC proliferation and neurogenesis by suppressing the tryptophan metabolism and reducing the production of serotonin. NSC proliferation was suppressed by serotonin via down-regulation of brain-derived neurotrophic factor (BDNF)-expression in serotonin-responsive periventricular neurons. BDNF enhances NSC plasticity and neurogenesis via nerve growth factor receptor A (NGFRA)/ nuclear factor 'kappa-light-chain-enhancer' of activated B-cells (NFkB) signaling in zebrafish but not in rodents. Collectively, our results suggest a complex neuron-glia interaction that regulates regenerative neurogenesis after AD conditions in zebrafish.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000585&type=printable |
| spellingShingle | Prabesh Bhattarai Mehmet Ilyas Cosacak Violeta Mashkaryan Sevgican Demir Stanislava Dimitrova Popova Nambirajan Govindarajan Kerstin Brandt Yixin Zhang Weipang Chang Konstantinos Ampatzis Caghan Kizil Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. PLoS Biology |
| title | Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. |
| title_full | Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. |
| title_fullStr | Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. |
| title_full_unstemmed | Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. |
| title_short | Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. |
| title_sort | neuron glia interaction through serotonin bdnf ngfr axis enables regenerative neurogenesis in alzheimer s model of adult zebrafish brain |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000585&type=printable |
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