Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic review

We reviewed trigeminal nerve stimulation (TNS) and transcutaneous vagus nerve stimulation (tVNS). All techniques have shown preliminary promising results, although the results are mixed. Method: We performed a systematic review of the Medline and Embase databases, with no constraint to dates, thro...

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Main Authors: Pedro Shiozawa, Mailu Enokibara da Silva, Thais Cristina de Carvalho, Quirino Cordeiro, André R. Brunoni, Felipe Fregni
Format: Article
Language:English
Published: Thieme Revinter Publicações 2014-07-01
Series:Arquivos de Neuro-Psiquiatria
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Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000700542&lng=en&tlng=en
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author Pedro Shiozawa
Mailu Enokibara da Silva
Thais Cristina de Carvalho
Quirino Cordeiro
André R. Brunoni
Felipe Fregni
author_facet Pedro Shiozawa
Mailu Enokibara da Silva
Thais Cristina de Carvalho
Quirino Cordeiro
André R. Brunoni
Felipe Fregni
author_sort Pedro Shiozawa
collection DOAJ
description We reviewed trigeminal nerve stimulation (TNS) and transcutaneous vagus nerve stimulation (tVNS). All techniques have shown preliminary promising results, although the results are mixed. Method: We performed a systematic review of the Medline and Embase databases, with no constraint to dates, through June 2013. The keywords were [(1) trigeminal nerve stimulation OR (2) cranial nerve OR (3) trigemin* OR (4) transcutaneous VNS OR (5) transcutaneous cranial nerve stimulation] and (6) mental disorders. Results: We included four preclinical and clinical five studies on TNS. All clinical data were based on open-label studies with small samples, which diminished the external validity of the results, thus reflecting the modest impact of TNS in current clinical practice. Of the tVNS clinical trials, three assessed physiological features in healthy volunteers, and one examined patients with epilepsy. Conclusion: TNS and tVNS improve treatment of particular neuropsychiatric disorders such as depression.
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institution Kabale University
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publisher Thieme Revinter Publicações
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series Arquivos de Neuro-Psiquiatria
spelling doaj-art-8d518ebec9bb458593adce6aa06ef15c2025-08-20T03:37:56ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272014-07-0172754254710.1590/0004-282X20140061S0004-282X2014000700542Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic reviewPedro ShiozawaMailu Enokibara da SilvaThais Cristina de CarvalhoQuirino CordeiroAndré R. BrunoniFelipe FregniWe reviewed trigeminal nerve stimulation (TNS) and transcutaneous vagus nerve stimulation (tVNS). All techniques have shown preliminary promising results, although the results are mixed. Method: We performed a systematic review of the Medline and Embase databases, with no constraint to dates, through June 2013. The keywords were [(1) trigeminal nerve stimulation OR (2) cranial nerve OR (3) trigemin* OR (4) transcutaneous VNS OR (5) transcutaneous cranial nerve stimulation] and (6) mental disorders. Results: We included four preclinical and clinical five studies on TNS. All clinical data were based on open-label studies with small samples, which diminished the external validity of the results, thus reflecting the modest impact of TNS in current clinical practice. Of the tVNS clinical trials, three assessed physiological features in healthy volunteers, and one examined patients with epilepsy. Conclusion: TNS and tVNS improve treatment of particular neuropsychiatric disorders such as depression.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000700542&lng=en&tlng=enestimulação transcutânea de nervos cranianosestimulação do nervo trigêmeodistúrbios neuropsiquiátricos
spellingShingle Pedro Shiozawa
Mailu Enokibara da Silva
Thais Cristina de Carvalho
Quirino Cordeiro
André R. Brunoni
Felipe Fregni
Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic review
Arquivos de Neuro-Psiquiatria
estimulação transcutânea de nervos cranianos
estimulação do nervo trigêmeo
distúrbios neuropsiquiátricos
title Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic review
title_full Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic review
title_fullStr Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic review
title_full_unstemmed Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic review
title_short Transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders: a systematic review
title_sort transcutaneous vagus and trigeminal nerve stimulation for neuropsychiatric disorders a systematic review
topic estimulação transcutânea de nervos cranianos
estimulação do nervo trigêmeo
distúrbios neuropsiquiátricos
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000700542&lng=en&tlng=en
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AT thaiscristinadecarvalho transcutaneousvagusandtrigeminalnervestimulationforneuropsychiatricdisordersasystematicreview
AT quirinocordeiro transcutaneousvagusandtrigeminalnervestimulationforneuropsychiatricdisordersasystematicreview
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