Efferocytosis: A new therapeutic target for stroke
Abstract. Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells, which is essential for maintaining tissue homeostasis both in physiological and pathological conditions. Numerous studies have demonstrated that efferocytosis can prevent secondary necrosis and pr...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2024-12-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003363 |
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| author | Li Gao Anatol Manaenko Feng Zeng Jingchen Li Lele Liu Ruichuan Xie Xiaohua Zhang John H. Zhang Qiyong Mei Jiping Tang Qin Hu Ting Gao |
| author_facet | Li Gao Anatol Manaenko Feng Zeng Jingchen Li Lele Liu Ruichuan Xie Xiaohua Zhang John H. Zhang Qiyong Mei Jiping Tang Qin Hu Ting Gao |
| author_sort | Li Gao |
| collection | DOAJ |
| description | Abstract. Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells, which is essential for maintaining tissue homeostasis both in physiological and pathological conditions. Numerous studies have demonstrated that efferocytosis can prevent secondary necrosis and proinflammatory factor release, leading to the resolution of inflammation and tissue immunological tolerance in numerous diseases such as stroke. Stroke is a leading cause of death and morbidity for adults worldwide. Persistent inflammation triggered by the dead cells or cell debris is a major contributor to post-stroke brain damage. Effective efferocytosis might be an efficient strategy to minimize inflammation and restore brain homeostasis for neuronal regeneration and function recovery. In this review, we will discuss the phagocytes in the brain, the molecular mechanisms underlying efferocytosis, the role of efferocytosis in inflammation resolution, and the potential therapeutic applications targeting efferocytosis in stroke. |
| format | Article |
| id | doaj-art-8d47d9ca2ed4429a88367767f3c7b963 |
| institution | OA Journals |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-8d47d9ca2ed4429a88367767f3c7b9632025-08-20T01:58:11ZengWolters KluwerChinese Medical Journal0366-69992542-56412024-12-01137232843285010.1097/CM9.0000000000003363202412050-00008Efferocytosis: A new therapeutic target for strokeLi Gao0Anatol Manaenko1Feng Zeng2Jingchen Li3Lele Liu4Ruichuan Xie5Xiaohua Zhang6John H. Zhang7Qiyong Mei8Jiping Tang9Qin Hu10Ting Gao1 Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China3 Clinical Neuroanatomy, Department of Neurology, School of Medicine, Ulm University, Ulm 89081, Germany4 Department of Neurosurgery, Changzheng Hospital, Naval Medical University, Shanghai 200003, China2 Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China2 Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China2 Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China1 Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China5 Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92354, USA4 Department of Neurosurgery, Changzheng Hospital, Naval Medical University, Shanghai 200003, China5 Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92354, USA1 Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, ChinaAbstract. Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells, which is essential for maintaining tissue homeostasis both in physiological and pathological conditions. Numerous studies have demonstrated that efferocytosis can prevent secondary necrosis and proinflammatory factor release, leading to the resolution of inflammation and tissue immunological tolerance in numerous diseases such as stroke. Stroke is a leading cause of death and morbidity for adults worldwide. Persistent inflammation triggered by the dead cells or cell debris is a major contributor to post-stroke brain damage. Effective efferocytosis might be an efficient strategy to minimize inflammation and restore brain homeostasis for neuronal regeneration and function recovery. In this review, we will discuss the phagocytes in the brain, the molecular mechanisms underlying efferocytosis, the role of efferocytosis in inflammation resolution, and the potential therapeutic applications targeting efferocytosis in stroke.http://journals.lww.com/10.1097/CM9.0000000000003363 |
| spellingShingle | Li Gao Anatol Manaenko Feng Zeng Jingchen Li Lele Liu Ruichuan Xie Xiaohua Zhang John H. Zhang Qiyong Mei Jiping Tang Qin Hu Ting Gao Efferocytosis: A new therapeutic target for stroke Chinese Medical Journal |
| title | Efferocytosis: A new therapeutic target for stroke |
| title_full | Efferocytosis: A new therapeutic target for stroke |
| title_fullStr | Efferocytosis: A new therapeutic target for stroke |
| title_full_unstemmed | Efferocytosis: A new therapeutic target for stroke |
| title_short | Efferocytosis: A new therapeutic target for stroke |
| title_sort | efferocytosis a new therapeutic target for stroke |
| url | http://journals.lww.com/10.1097/CM9.0000000000003363 |
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