INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTION
Goal of the study: to develop individual approaches to the choice of chemotherapy regimens for respiratory tuberculosis in children exposed to multiple drug resistant tuberculous infection. Materials and methods. Totally 39 children (3-12 years old) with tuberculosis of chest lymph nodes or pulmonar...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2016-09-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/925 |
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| author | M. F. Gubkina Yu. Yu. Khokhlova N. V. Yukhimenko I. Yu. Petrakova |
| author_facet | M. F. Gubkina Yu. Yu. Khokhlova N. V. Yukhimenko I. Yu. Petrakova |
| author_sort | M. F. Gubkina |
| collection | DOAJ |
| description | Goal of the study: to develop individual approaches to the choice of chemotherapy regimens for respiratory tuberculosis in children exposed to multiple drug resistant tuberculous infection. Materials and methods. Totally 39 children (3-12 years old) with tuberculosis of chest lymph nodes or pulmonary tuberculosis. Patients were divided into 3 groups: Group 1 (9 persons) with minimal changes – 3 drugs (ZPASPtо), Group 2 (15 persons) with limited lesions – 4 drugs (ZPtоPASE), Group 3 (15 persons) with disseminated lesions – 5 drugs (ZPASPtоAmFq). Duration of chemotherapy: Group 1 – 9.4 ± 0.7 months; Group 2 – 9.0 ± 1.1 months (administration of 4 drugs during the whole treatment course) and 10.5 ± 0.9 months, (transfer after the intensive phase (3.1 ± 0.7 months) to 3 drugs), Group 3 – 13.4 ± 0.7 months. (Transfer after the intensive phase (4.0 ± 0.4 months) to 4 drugs).Results. Chemotherapy course was assessed assuccessful in all groups. Individual approaches to the choice of chemotherapy regimens oftuberculosis in children exposed to multiple drug resistant tuberculous infection should consider not only the data on drug susceptibility of the infection source but also the dissemination of tuberculous lesions in the child. |
| format | Article |
| id | doaj-art-8d4707d043f342eeb8957e6010eb08f3 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2016-09-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-8d4707d043f342eeb8957e6010eb08f32025-08-20T01:47:52ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062016-09-01949242910.21292/2075-1230-2016-94-9-24-29925INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTIONM. F. Gubkina0Yu. Yu. Khokhlova1N. V. Yukhimenko2I. Yu. Petrakova3Central Tuberculosis Research Institute; Pirogov Russian National Research Medical UniversityCentral Tuberculosis Research InstituteCentral Tuberculosis Research InstituteCentral Tuberculosis Research InstituteGoal of the study: to develop individual approaches to the choice of chemotherapy regimens for respiratory tuberculosis in children exposed to multiple drug resistant tuberculous infection. Materials and methods. Totally 39 children (3-12 years old) with tuberculosis of chest lymph nodes or pulmonary tuberculosis. Patients were divided into 3 groups: Group 1 (9 persons) with minimal changes – 3 drugs (ZPASPtо), Group 2 (15 persons) with limited lesions – 4 drugs (ZPtоPASE), Group 3 (15 persons) with disseminated lesions – 5 drugs (ZPASPtоAmFq). Duration of chemotherapy: Group 1 – 9.4 ± 0.7 months; Group 2 – 9.0 ± 1.1 months (administration of 4 drugs during the whole treatment course) and 10.5 ± 0.9 months, (transfer after the intensive phase (3.1 ± 0.7 months) to 3 drugs), Group 3 – 13.4 ± 0.7 months. (Transfer after the intensive phase (4.0 ± 0.4 months) to 4 drugs).Results. Chemotherapy course was assessed assuccessful in all groups. Individual approaches to the choice of chemotherapy regimens oftuberculosis in children exposed to multiple drug resistant tuberculous infection should consider not only the data on drug susceptibility of the infection source but also the dissemination of tuberculous lesions in the child.https://www.tibl-journal.com/jour/article/view/925tuberculosischildrenchemotherapymultiple drug resistanceepidemic foci of tuberculosis |
| spellingShingle | M. F. Gubkina Yu. Yu. Khokhlova N. V. Yukhimenko I. Yu. Petrakova INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTION Туберкулез и болезни лёгких tuberculosis children chemotherapy multiple drug resistance epidemic foci of tuberculosis |
| title | INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTION |
| title_full | INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTION |
| title_fullStr | INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTION |
| title_full_unstemmed | INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTION |
| title_short | INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTION |
| title_sort | individual approaches to the choice of chemotherapy regimens for respiratory tuberculosis in children exposed to multiple drug resistant tuberculous infection |
| topic | tuberculosis children chemotherapy multiple drug resistance epidemic foci of tuberculosis |
| url | https://www.tibl-journal.com/jour/article/view/925 |
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