Biological interpretation of DNA/RNA modification by ALKBH proteins and their role in human cancer

Biological interpretation of DNA/RNA modification by ALKBH proteins and their role in human cancer

Abstract AlkB homolog (ALKBH) belongs to 2-oxoglutarate (2OG) and ferrous iron-dependent oxygenases, which can catalyze the demethylation of DNA/RNA and play an important role in human diseases represented by cancer. Although ALKBH has been extensively studied, the biological explanation for its spe...

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Bibliographic Details
Main Authors: Siqi Yang, Jixiang Xing, Yancheng Song, Jiafu Cui, Lingling Bao, Qilemuge Xi, Yongchun Zuo
Format: Article
Language:English
Published: BMC 2025-06-01
Series:European Journal of Medical Research
Subjects:
Structural topology
Omics analysis
DNA/RNA recognition
Tissue-specific expression
Signaling pathways
Online Access:https://doi.org/10.1186/s40001-025-02735-9
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