Coronary artery disease-associated genetic variants and biomarkers of inflammation.
<h4>Introduction</h4>Genetic constitution and inflammation both contribute to development of coronary artery disease (CAD). Several CAD-associated single-nucleotide polymorphisms (SNPs) have recently been identified, but their functions are largely unknown. We investigated the associatio...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0180365&type=printable |
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| author | Morten Krogh Christiansen Sanne Bøjet Larsen Mette Nyegaard Søs Neergaard-Petersen Ramzi Ajjan Morten Würtz Erik Lerkevang Grove Anne-Mette Hvas Henrik Kjærulf Jensen Steen Dalby Kristensen |
| author_facet | Morten Krogh Christiansen Sanne Bøjet Larsen Mette Nyegaard Søs Neergaard-Petersen Ramzi Ajjan Morten Würtz Erik Lerkevang Grove Anne-Mette Hvas Henrik Kjærulf Jensen Steen Dalby Kristensen |
| author_sort | Morten Krogh Christiansen |
| collection | DOAJ |
| description | <h4>Introduction</h4>Genetic constitution and inflammation both contribute to development of coronary artery disease (CAD). Several CAD-associated single-nucleotide polymorphisms (SNPs) have recently been identified, but their functions are largely unknown. We investigated the associations between CAD-associated SNPs and five CAD-related inflammatory biomarkers.<h4>Methods</h4>We genotyped 45 CAD-associated SNPs in 701 stable CAD patients in whom levels of high-sensitivity C-reactive protein (hsRCP), interleukin-6, calprotectin, fibrinogen and complement component 3 levels had previously been measured. A genetic risk score was calculated to assess the combined risk associated with all the genetic variants. A multiple linear regression model was used to assess associations between the genetic risk score, single SNPs, and the five inflammatory biomarkers.<h4>Results</h4>The minor allele (G) (CAD risk allele) of rs2075650 (TOMM40/APOE) was associated with lower levels of high-sensitivity C-reactive protein (effect per risk allele: -0.37 mg/l [95%CI -0.56 to -0.18 mg/l]). The inflammatory markers tested showed no association with the remaining 44 SNPs or with the genetic risk score.<h4>Conclusions</h4>In stable CAD patients, the risk allele of a common CAD-associated marker at the TOMM40/APOE locus was associated with lower hsCRP levels. No other genetic variants or the combined effect of all variants were associated with the five inflammatory biomarkers. |
| format | Article |
| id | doaj-art-8d34d9f791af470584545151048b18a7 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-8d34d9f791af470584545151048b18a72025-01-17T05:32:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018036510.1371/journal.pone.0180365Coronary artery disease-associated genetic variants and biomarkers of inflammation.Morten Krogh ChristiansenSanne Bøjet LarsenMette NyegaardSøs Neergaard-PetersenRamzi AjjanMorten WürtzErik Lerkevang GroveAnne-Mette HvasHenrik Kjærulf JensenSteen Dalby Kristensen<h4>Introduction</h4>Genetic constitution and inflammation both contribute to development of coronary artery disease (CAD). Several CAD-associated single-nucleotide polymorphisms (SNPs) have recently been identified, but their functions are largely unknown. We investigated the associations between CAD-associated SNPs and five CAD-related inflammatory biomarkers.<h4>Methods</h4>We genotyped 45 CAD-associated SNPs in 701 stable CAD patients in whom levels of high-sensitivity C-reactive protein (hsRCP), interleukin-6, calprotectin, fibrinogen and complement component 3 levels had previously been measured. A genetic risk score was calculated to assess the combined risk associated with all the genetic variants. A multiple linear regression model was used to assess associations between the genetic risk score, single SNPs, and the five inflammatory biomarkers.<h4>Results</h4>The minor allele (G) (CAD risk allele) of rs2075650 (TOMM40/APOE) was associated with lower levels of high-sensitivity C-reactive protein (effect per risk allele: -0.37 mg/l [95%CI -0.56 to -0.18 mg/l]). The inflammatory markers tested showed no association with the remaining 44 SNPs or with the genetic risk score.<h4>Conclusions</h4>In stable CAD patients, the risk allele of a common CAD-associated marker at the TOMM40/APOE locus was associated with lower hsCRP levels. No other genetic variants or the combined effect of all variants were associated with the five inflammatory biomarkers.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0180365&type=printable |
| spellingShingle | Morten Krogh Christiansen Sanne Bøjet Larsen Mette Nyegaard Søs Neergaard-Petersen Ramzi Ajjan Morten Würtz Erik Lerkevang Grove Anne-Mette Hvas Henrik Kjærulf Jensen Steen Dalby Kristensen Coronary artery disease-associated genetic variants and biomarkers of inflammation. PLoS ONE |
| title | Coronary artery disease-associated genetic variants and biomarkers of inflammation. |
| title_full | Coronary artery disease-associated genetic variants and biomarkers of inflammation. |
| title_fullStr | Coronary artery disease-associated genetic variants and biomarkers of inflammation. |
| title_full_unstemmed | Coronary artery disease-associated genetic variants and biomarkers of inflammation. |
| title_short | Coronary artery disease-associated genetic variants and biomarkers of inflammation. |
| title_sort | coronary artery disease associated genetic variants and biomarkers of inflammation |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0180365&type=printable |
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