Negative correlation between maorophage proooagulant and migraion ability in the course of inflammation
The importance of macrophage procoagulant activity (PCA) to cell migration is presumed. In this study we assayed the relationship between the two functions in guinea-pig peritoneal resident macrophages and cells elicited by a sterile inflammation induction, which lasted up to 6 days. The findings po...
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| Format: | Article |
| Language: | English |
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Wiley
1996-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935196000397 |
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| _version_ | 1849401504395427840 |
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| author | I. Vilic L. M. Prokic |
| author_facet | I. Vilic L. M. Prokic |
| author_sort | I. Vilic |
| collection | DOAJ |
| description | The importance of macrophage procoagulant activity (PCA) to cell migration is presumed. In this study we assayed the relationship between the two functions in guinea-pig peritoneal resident macrophages and cells elicited by a sterile inflammation induction, which lasted up to 6 days. The findings pointed to an in vivo induction of PCA in macrophages, which declined with time during inflammation. A clear negative correlation between PCA and random migration ability was demonstrated. Our results suggest that the local induction of coagulation by macrophages may immobilize the cells at the site of inflammation. |
| format | Article |
| id | doaj-art-8d2b28830c42452a98fcbc89ea4dcbb1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8d2b28830c42452a98fcbc89ea4dcbb12025-08-20T03:37:45ZengWileyMediators of Inflammation0962-93511466-18611996-01-015427127510.1155/S0962935196000397Negative correlation between maorophage proooagulant and migraion ability in the course of inflammationI. Vilic0L. M. Prokic1Institute of Physiology, Medical Faculty, Belgrade University, PO Box 783, Belgrade 11001, SerbiaInstitute of Physiology, Medical Faculty, Belgrade University, PO Box 783, Belgrade 11001, SerbiaThe importance of macrophage procoagulant activity (PCA) to cell migration is presumed. In this study we assayed the relationship between the two functions in guinea-pig peritoneal resident macrophages and cells elicited by a sterile inflammation induction, which lasted up to 6 days. The findings pointed to an in vivo induction of PCA in macrophages, which declined with time during inflammation. A clear negative correlation between PCA and random migration ability was demonstrated. Our results suggest that the local induction of coagulation by macrophages may immobilize the cells at the site of inflammation.http://dx.doi.org/10.1155/S0962935196000397 |
| spellingShingle | I. Vilic L. M. Prokic Negative correlation between maorophage proooagulant and migraion ability in the course of inflammation Mediators of Inflammation |
| title | Negative correlation between maorophage proooagulant and migraion ability in the course of inflammation |
| title_full | Negative correlation between maorophage proooagulant and migraion ability in the course of inflammation |
| title_fullStr | Negative correlation between maorophage proooagulant and migraion ability in the course of inflammation |
| title_full_unstemmed | Negative correlation between maorophage proooagulant and migraion ability in the course of inflammation |
| title_short | Negative correlation between maorophage proooagulant and migraion ability in the course of inflammation |
| title_sort | negative correlation between maorophage proooagulant and migraion ability in the course of inflammation |
| url | http://dx.doi.org/10.1155/S0962935196000397 |
| work_keys_str_mv | AT ivilic negativecorrelationbetweenmaorophageproooagulantandmigraionabilityinthecourseofinflammation AT lmprokic negativecorrelationbetweenmaorophageproooagulantandmigraionabilityinthecourseofinflammation |