The Role of Heat Shock Proteins in Systemic Vascular Catastrophes and in Acute Vascular Diseases of an Eye
The disruption of blood flow through the retinal vessels is undoubtedly a stressful situation for the body. In response to any stress, the body produces heat shock proteins or so-called stress proteins. Moreover, a number of modern studies indicate that HSP may act as autoantigens, which are compone...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2022-04-01
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| Series: | Oftalʹmologiâ |
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| Online Access: | https://www.ophthalmojournal.com/opht/article/view/1770 |
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| author | L. K. Moshetova S. A. Usharova S. V. Simonova K. I. Turkina I. N. Saburina |
| author_facet | L. K. Moshetova S. A. Usharova S. V. Simonova K. I. Turkina I. N. Saburina |
| author_sort | L. K. Moshetova |
| collection | DOAJ |
| description | The disruption of blood flow through the retinal vessels is undoubtedly a stressful situation for the body. In response to any stress, the body produces heat shock proteins or so-called stress proteins. Moreover, a number of modern studies indicate that HSP may act as autoantigens, which are components of the immune system involved in the pathogenesis of vascular pathologies. By now, a number of certain heat shock proteins (HSP 60, 70) have already been proven to play a significant role in the pathogenesis of atherosclerosis as well as various circulatory disorders in the cerebral vessels. In addition, the possibility of using the data on the content and concentration of certain HSPs and antibodies to them in the blood plasma of patients as diagnostic and prognostic markers of systemic vascular diseases is considered. On the visual organ side, HSPs have been found to have damaging effects on retinal ganglion cells and, together with antibodies produced in response to their presence, are involved in the pathogenesis of glaucoma. However, there is currently no data on the role of HSP in the pathogenesis of retinal blood flow disorders and the possibility of using these molecules as diagnostic or prognostic markers of such conditions. |
| format | Article |
| id | doaj-art-8d29de65340f404e94a7e1c385400d15 |
| institution | Kabale University |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2022-04-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-8d29de65340f404e94a7e1c385400d152025-08-20T03:38:18ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452022-04-01191535710.18008/1816-5095-2022-1-53-57862The Role of Heat Shock Proteins in Systemic Vascular Catastrophes and in Acute Vascular Diseases of an EyeL. K. Moshetova0S. A. Usharova1S. V. Simonova2K. I. Turkina3I. N. Saburina4Russian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional Education; Research Institute for Healthcare Organization and Medical ManagementRussian Medical Academy of Continuous Professional EducationInstitute of General Pathology and PathophysiologyThe disruption of blood flow through the retinal vessels is undoubtedly a stressful situation for the body. In response to any stress, the body produces heat shock proteins or so-called stress proteins. Moreover, a number of modern studies indicate that HSP may act as autoantigens, which are components of the immune system involved in the pathogenesis of vascular pathologies. By now, a number of certain heat shock proteins (HSP 60, 70) have already been proven to play a significant role in the pathogenesis of atherosclerosis as well as various circulatory disorders in the cerebral vessels. In addition, the possibility of using the data on the content and concentration of certain HSPs and antibodies to them in the blood plasma of patients as diagnostic and prognostic markers of systemic vascular diseases is considered. On the visual organ side, HSPs have been found to have damaging effects on retinal ganglion cells and, together with antibodies produced in response to their presence, are involved in the pathogenesis of glaucoma. However, there is currently no data on the role of HSP in the pathogenesis of retinal blood flow disorders and the possibility of using these molecules as diagnostic or prognostic markers of such conditions.https://www.ophthalmojournal.com/opht/article/view/1770heat shock proteinsretinal vascular occlusionsvascular pathologystress proteins |
| spellingShingle | L. K. Moshetova S. A. Usharova S. V. Simonova K. I. Turkina I. N. Saburina The Role of Heat Shock Proteins in Systemic Vascular Catastrophes and in Acute Vascular Diseases of an Eye Oftalʹmologiâ heat shock proteins retinal vascular occlusions vascular pathology stress proteins |
| title | The Role of Heat Shock Proteins in Systemic Vascular Catastrophes and in Acute Vascular Diseases of an Eye |
| title_full | The Role of Heat Shock Proteins in Systemic Vascular Catastrophes and in Acute Vascular Diseases of an Eye |
| title_fullStr | The Role of Heat Shock Proteins in Systemic Vascular Catastrophes and in Acute Vascular Diseases of an Eye |
| title_full_unstemmed | The Role of Heat Shock Proteins in Systemic Vascular Catastrophes and in Acute Vascular Diseases of an Eye |
| title_short | The Role of Heat Shock Proteins in Systemic Vascular Catastrophes and in Acute Vascular Diseases of an Eye |
| title_sort | role of heat shock proteins in systemic vascular catastrophes and in acute vascular diseases of an eye |
| topic | heat shock proteins retinal vascular occlusions vascular pathology stress proteins |
| url | https://www.ophthalmojournal.com/opht/article/view/1770 |
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