Inflammatory Biomarkers as Prognostic Indicators for Intracranial Aneurysm Recurrence After Stent‐Assisted Coil Embolization
ABSTRACT Background The reappearance of intracranial aneurysms (IAs) after undergoing stent‐assisted coil embolization (SACE) is a significant issue in clinical practice. In this study, we analyzed blood regulatory T‐cell counts and plasma cytokine levels to assess the extent of systemic inflammatio...
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Wiley
2025-07-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.70240 |
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| author | Jie Wei Jinghui Lin Junjun Zhang Zifeng Dai Yiyong Zeng Xianru Li Yong Li Jianfei Zhang Zhiqing Lin Shengjun Zhou |
| author_facet | Jie Wei Jinghui Lin Junjun Zhang Zifeng Dai Yiyong Zeng Xianru Li Yong Li Jianfei Zhang Zhiqing Lin Shengjun Zhou |
| author_sort | Jie Wei |
| collection | DOAJ |
| description | ABSTRACT Background The reappearance of intracranial aneurysms (IAs) after undergoing stent‐assisted coil embolization (SACE) is a significant issue in clinical practice. In this study, we analyzed blood regulatory T‐cell counts and plasma cytokine levels to assess the extent of systemic inflammation and investigate their potential association with the recurrence of IAs undergoing SACE. Methods A total of 189 individuals with 220 unruptured IAs were included in a retrospective study, with participants categorized into groups of occlusion and recurrence according to the Raymond–Roy Scale. Initially, a univariate analysis was used to identify distinctions among clinical data, morphological parameters, and preoperative plasma cytokine levels. A logistic regression model was built using variables with a significance level of p < 0.05, and the specificity and sensitivity of the chosen parameters were assessed through graphical and statistical analysis using receiver operating characteristic (ROC) curve techniques. Results In the group with recurrence, the plasma concentrations of IL‐2, IL‐10, IL‐17, and IFN‐γ were notably elevated compared to the occlusion group. Based on binary logistic regression analysis, it was found that the levels of IL‐10 (odds ratio = 1.24, 95% CI = 1.06–1.46, p = 0.008), IL‐17 (odds ratio = 1.45, 95% CI = 1.17–1.82, p < 0.001), and INF‐γ (odds ratio = 1.28, 95% CI = 1.07–1.54, p = 0.007) were determined to be crucial independent indicators for the recurrence of IAs. The highest predictive accuracy recurrence risk, with an area under the curve of 0.761, was achieved through the combination of IL‐2, IL‐10, IL‐17, and INF‐γ. Conclusions Findings reveal indicate that elevated levels of plasma IL‐2, IL‐10, IL‐17, and IFN‐γ are consistently present in recurrent IAs, implying that the initial inflammatory levels in the body are a major contributor to the recurrence of IAs following SACE. The combination of IL‐2, IL‐10, IL‐17, and IFN‐γ may assist in predicting the likelihood of recurrence in IAs following SACE. |
| format | Article |
| id | doaj-art-8d28580f1c7a4c79ab6a765e43a75075 |
| institution | Kabale University |
| issn | 2050-4527 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
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| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-8d28580f1c7a4c79ab6a765e43a750752025-08-20T03:58:37ZengWileyImmunity, Inflammation and Disease2050-45272025-07-01137n/an/a10.1002/iid3.70240Inflammatory Biomarkers as Prognostic Indicators for Intracranial Aneurysm Recurrence After Stent‐Assisted Coil EmbolizationJie Wei0Jinghui Lin1Junjun Zhang2Zifeng Dai3Yiyong Zeng4Xianru Li5Yong Li6Jianfei Zhang7Zhiqing Lin8Shengjun Zhou9Department of Neurosurgery The First Affiliated Hospital of Ningbo University Ningbo ChinaDepartment of Neurosurgery The First Affiliated Hospital of Ningbo University Ningbo ChinaDepartment of Neurosurgery The First Affiliated Hospital of Ningbo University Ningbo ChinaDepartment of Neurosurgery The First Affiliated Hospital of Ningbo University Ningbo ChinaDepartment of Neurosurgery The First Affiliated Hospital of Ningbo University Ningbo ChinaDepartment of Neurosurgery The First Affiliated Hospital of Ningbo University Ningbo ChinaDepartment of Neurosurgery The First Affiliated Hospital of Ningbo University Ningbo ChinaDepartment of Neurosurgery The First Affiliated Hospital of Ningbo University Ningbo ChinaDepartment of Neurosurgery The First Affiliated Hospital of Ningbo University Ningbo ChinaDepartment of Neurosurgery The First Affiliated Hospital of Ningbo University Ningbo ChinaABSTRACT Background The reappearance of intracranial aneurysms (IAs) after undergoing stent‐assisted coil embolization (SACE) is a significant issue in clinical practice. In this study, we analyzed blood regulatory T‐cell counts and plasma cytokine levels to assess the extent of systemic inflammation and investigate their potential association with the recurrence of IAs undergoing SACE. Methods A total of 189 individuals with 220 unruptured IAs were included in a retrospective study, with participants categorized into groups of occlusion and recurrence according to the Raymond–Roy Scale. Initially, a univariate analysis was used to identify distinctions among clinical data, morphological parameters, and preoperative plasma cytokine levels. A logistic regression model was built using variables with a significance level of p < 0.05, and the specificity and sensitivity of the chosen parameters were assessed through graphical and statistical analysis using receiver operating characteristic (ROC) curve techniques. Results In the group with recurrence, the plasma concentrations of IL‐2, IL‐10, IL‐17, and IFN‐γ were notably elevated compared to the occlusion group. Based on binary logistic regression analysis, it was found that the levels of IL‐10 (odds ratio = 1.24, 95% CI = 1.06–1.46, p = 0.008), IL‐17 (odds ratio = 1.45, 95% CI = 1.17–1.82, p < 0.001), and INF‐γ (odds ratio = 1.28, 95% CI = 1.07–1.54, p = 0.007) were determined to be crucial independent indicators for the recurrence of IAs. The highest predictive accuracy recurrence risk, with an area under the curve of 0.761, was achieved through the combination of IL‐2, IL‐10, IL‐17, and INF‐γ. Conclusions Findings reveal indicate that elevated levels of plasma IL‐2, IL‐10, IL‐17, and IFN‐γ are consistently present in recurrent IAs, implying that the initial inflammatory levels in the body are a major contributor to the recurrence of IAs following SACE. The combination of IL‐2, IL‐10, IL‐17, and IFN‐γ may assist in predicting the likelihood of recurrence in IAs following SACE.https://doi.org/10.1002/iid3.70240cytokinesinterleukinsprediction modelstent‐assisted coil embolizationunruptured intracranial aneurysms |
| spellingShingle | Jie Wei Jinghui Lin Junjun Zhang Zifeng Dai Yiyong Zeng Xianru Li Yong Li Jianfei Zhang Zhiqing Lin Shengjun Zhou Inflammatory Biomarkers as Prognostic Indicators for Intracranial Aneurysm Recurrence After Stent‐Assisted Coil Embolization Immunity, Inflammation and Disease cytokines interleukins prediction model stent‐assisted coil embolization unruptured intracranial aneurysms |
| title | Inflammatory Biomarkers as Prognostic Indicators for Intracranial Aneurysm Recurrence After Stent‐Assisted Coil Embolization |
| title_full | Inflammatory Biomarkers as Prognostic Indicators for Intracranial Aneurysm Recurrence After Stent‐Assisted Coil Embolization |
| title_fullStr | Inflammatory Biomarkers as Prognostic Indicators for Intracranial Aneurysm Recurrence After Stent‐Assisted Coil Embolization |
| title_full_unstemmed | Inflammatory Biomarkers as Prognostic Indicators for Intracranial Aneurysm Recurrence After Stent‐Assisted Coil Embolization |
| title_short | Inflammatory Biomarkers as Prognostic Indicators for Intracranial Aneurysm Recurrence After Stent‐Assisted Coil Embolization |
| title_sort | inflammatory biomarkers as prognostic indicators for intracranial aneurysm recurrence after stent assisted coil embolization |
| topic | cytokines interleukins prediction model stent‐assisted coil embolization unruptured intracranial aneurysms |
| url | https://doi.org/10.1002/iid3.70240 |
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