Assessing the effect of the probiotic in the effectiveness of the Newcastle disease vaccine in specific pathogen-free chickens
Summary: The present study aimed to assess the impact of a probiotic supplement on the effectiveness of the Newcastle disease (ND) vaccine in specific pathogen-free (SPF) chickens. A total of one hundred and twenty 7-day-old SPF chicks were randomly divided into six groups including: CNT (control gr...
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Elsevier
2025-09-01
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| Series: | Journal of Applied Poultry Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1056617125000340 |
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| author | Navid Asgharian Mohammad Amir Karimi Torshizi Naheed Mojgani Shaban Rahimi Mohammad Majid Ebrahimi |
| author_facet | Navid Asgharian Mohammad Amir Karimi Torshizi Naheed Mojgani Shaban Rahimi Mohammad Majid Ebrahimi |
| author_sort | Navid Asgharian |
| collection | DOAJ |
| description | Summary: The present study aimed to assess the impact of a probiotic supplement on the effectiveness of the Newcastle disease (ND) vaccine in specific pathogen-free (SPF) chickens. A total of one hundred and twenty 7-day-old SPF chicks were randomly divided into six groups including: CNT (control group), PRO (probiotic), RCV (Razi Clone12IR vaccine), ICV (imported Clone vaccine), PRO + RCV (probiotic and Razi Clone12IR vaccine), and PRO + ICV (probiotic and imported Clone vaccine). Administration of the probiotic, either alone or in conjunction with ND vaccination, decreased cholesterol and increased total protein, albumin, calcium, and phosphorus concentrations (P < 0.05). Increasing weight, length, and bone breaking strength were observed in chickens that were given the probiotic alone. The highest concentration of malondialdehyde (MDA) was recorded in the CNT, while MDA levels decreased in the PRO, PRO + RCV, and PRO + ICV (P < 0.05). An increase in IgY anti-SRBC antibody titer was found in the PRO + RCV and PRO + ICV groups. Higher antibody titer against ND was observed in the PRO + RCV (P < 0.05). The use of probiotics during ND vaccination led to increased lysozyme activity compared to other groups (P < 0.05). The birds receiving probiotics exhibited significantly greater villus height, crypt depth, and villus height/crypt depth ratio in the duodenum (P < 0.05). No histopathological lesions were observed in the trachea, lungs, liver, or bursa of Fabricius in vaccinated chickens, regardless of whether they received probiotic dietary supplementation. The study’s findings suggest that incorporating probiotics during ND vaccination can enhance the health-related parameters of SPF chickens. |
| format | Article |
| id | doaj-art-8d262d32dae846e3bd28ac6e7e383f4f |
| institution | Kabale University |
| issn | 1056-6171 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Applied Poultry Research |
| spelling | doaj-art-8d262d32dae846e3bd28ac6e7e383f4f2025-08-20T05:04:33ZengElsevierJournal of Applied Poultry Research1056-61712025-09-0134310054910.1016/j.japr.2025.100549Assessing the effect of the probiotic in the effectiveness of the Newcastle disease vaccine in specific pathogen-free chickensNavid Asgharian0Mohammad Amir Karimi Torshizi1Naheed Mojgani2Shaban Rahimi3Mohammad Majid Ebrahimi4Department of Poultry Science, Faculty of Agriculture, Tarbiat Modares University, Tehran 1411713116, IranDepartment of Poultry Science, Faculty of Agriculture, Tarbiat Modares University, Tehran 1411713116, Iran; Corresponding authors.Biotechnology Department, Razi Vaccine and Serum Research Institute- Agriculture Research, Education and Extension Organization, Karaj, Iran; Corresponding authors.Department of Poultry Science, Faculty of Agriculture, Tarbiat Modares University, Tehran 1411713116, IranPoultry Vaccines Research and Production Department, Razi Vaccine and Serum Research Institute- Agricultural Research, Education and Extension Organization, Karaj 3197619751, IranSummary: The present study aimed to assess the impact of a probiotic supplement on the effectiveness of the Newcastle disease (ND) vaccine in specific pathogen-free (SPF) chickens. A total of one hundred and twenty 7-day-old SPF chicks were randomly divided into six groups including: CNT (control group), PRO (probiotic), RCV (Razi Clone12IR vaccine), ICV (imported Clone vaccine), PRO + RCV (probiotic and Razi Clone12IR vaccine), and PRO + ICV (probiotic and imported Clone vaccine). Administration of the probiotic, either alone or in conjunction with ND vaccination, decreased cholesterol and increased total protein, albumin, calcium, and phosphorus concentrations (P < 0.05). Increasing weight, length, and bone breaking strength were observed in chickens that were given the probiotic alone. The highest concentration of malondialdehyde (MDA) was recorded in the CNT, while MDA levels decreased in the PRO, PRO + RCV, and PRO + ICV (P < 0.05). An increase in IgY anti-SRBC antibody titer was found in the PRO + RCV and PRO + ICV groups. Higher antibody titer against ND was observed in the PRO + RCV (P < 0.05). The use of probiotics during ND vaccination led to increased lysozyme activity compared to other groups (P < 0.05). The birds receiving probiotics exhibited significantly greater villus height, crypt depth, and villus height/crypt depth ratio in the duodenum (P < 0.05). No histopathological lesions were observed in the trachea, lungs, liver, or bursa of Fabricius in vaccinated chickens, regardless of whether they received probiotic dietary supplementation. The study’s findings suggest that incorporating probiotics during ND vaccination can enhance the health-related parameters of SPF chickens.http://www.sciencedirect.com/science/article/pii/S1056617125000340Immune responseNewcastle diseaseProbioticSPF chicksVaccination |
| spellingShingle | Navid Asgharian Mohammad Amir Karimi Torshizi Naheed Mojgani Shaban Rahimi Mohammad Majid Ebrahimi Assessing the effect of the probiotic in the effectiveness of the Newcastle disease vaccine in specific pathogen-free chickens Journal of Applied Poultry Research Immune response Newcastle disease Probiotic SPF chicks Vaccination |
| title | Assessing the effect of the probiotic in the effectiveness of the Newcastle disease vaccine in specific pathogen-free chickens |
| title_full | Assessing the effect of the probiotic in the effectiveness of the Newcastle disease vaccine in specific pathogen-free chickens |
| title_fullStr | Assessing the effect of the probiotic in the effectiveness of the Newcastle disease vaccine in specific pathogen-free chickens |
| title_full_unstemmed | Assessing the effect of the probiotic in the effectiveness of the Newcastle disease vaccine in specific pathogen-free chickens |
| title_short | Assessing the effect of the probiotic in the effectiveness of the Newcastle disease vaccine in specific pathogen-free chickens |
| title_sort | assessing the effect of the probiotic in the effectiveness of the newcastle disease vaccine in specific pathogen free chickens |
| topic | Immune response Newcastle disease Probiotic SPF chicks Vaccination |
| url | http://www.sciencedirect.com/science/article/pii/S1056617125000340 |
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