Pediatric cardiac surgery under cardiopulmonary bypass in factor VII deficiency
We present a case of an atrial septal defect repair under cardiopulmonary bypass in a child with factor VII deficiency. A four-year-old girl, with the diagnosis of secundum atrial septal defect, was referred to surgery. Coagulation tests showed an international normalized ratio of 2.4. Furthe...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2010-02-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/4941 |
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| _version_ | 1850024132549279744 |
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| author | Ozan Emiroğlu Zeynep Eyileten Tayfun Uçar Talya Ileri |
| author_facet | Ozan Emiroğlu Zeynep Eyileten Tayfun Uçar Talya Ileri |
| author_sort | Ozan Emiroğlu |
| collection | DOAJ |
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We present a case of an atrial septal defect repair under cardiopulmonary bypass in a child with factor VII deficiency. A four-year-old girl, with the diagnosis of secundum atrial septal defect, was referred to surgery. Coagulation tests showed an international normalized ratio of 2.4. Further investigations revealed deficiency of factor VII with 42% activity. Fifteen minutes before the induction of anesthesia, 20 microg/kg dose of recombinant factor VIIa concentrate was administrated. The atrial septal defect repair was performed uneventfully. Factor VII activity markedly improved to 174%, and international normalized ratio declined to 1.1 within 1.5 hours after the substitution therapy. In our case, under a low-dose substitution therapy with recombinant factor VIIa concentrate, atrial septal defect repair under cardiopulmonary bypass was performed safely in a child with moderate congenital factor VII deficiency.
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| format | Article |
| id | doaj-art-8d23af932c5f483facfa08c1153aaa3f |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2010-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-8d23af932c5f483facfa08c1153aaa3f2025-08-20T03:01:11ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212010-02-01521Pediatric cardiac surgery under cardiopulmonary bypass in factor VII deficiencyOzan Emiroğlu0Zeynep EyiletenTayfun UçarTalya IleriDepartment of Cardiac Surgery, Ankara University Faculty of Medicine, Ankara, Turkey. We present a case of an atrial septal defect repair under cardiopulmonary bypass in a child with factor VII deficiency. A four-year-old girl, with the diagnosis of secundum atrial septal defect, was referred to surgery. Coagulation tests showed an international normalized ratio of 2.4. Further investigations revealed deficiency of factor VII with 42% activity. Fifteen minutes before the induction of anesthesia, 20 microg/kg dose of recombinant factor VIIa concentrate was administrated. The atrial septal defect repair was performed uneventfully. Factor VII activity markedly improved to 174%, and international normalized ratio declined to 1.1 within 1.5 hours after the substitution therapy. In our case, under a low-dose substitution therapy with recombinant factor VIIa concentrate, atrial septal defect repair under cardiopulmonary bypass was performed safely in a child with moderate congenital factor VII deficiency. https://turkjpediatr.org/article/view/4941 |
| spellingShingle | Ozan Emiroğlu Zeynep Eyileten Tayfun Uçar Talya Ileri Pediatric cardiac surgery under cardiopulmonary bypass in factor VII deficiency The Turkish Journal of Pediatrics |
| title | Pediatric cardiac surgery under cardiopulmonary bypass in factor VII deficiency |
| title_full | Pediatric cardiac surgery under cardiopulmonary bypass in factor VII deficiency |
| title_fullStr | Pediatric cardiac surgery under cardiopulmonary bypass in factor VII deficiency |
| title_full_unstemmed | Pediatric cardiac surgery under cardiopulmonary bypass in factor VII deficiency |
| title_short | Pediatric cardiac surgery under cardiopulmonary bypass in factor VII deficiency |
| title_sort | pediatric cardiac surgery under cardiopulmonary bypass in factor vii deficiency |
| url | https://turkjpediatr.org/article/view/4941 |
| work_keys_str_mv | AT ozanemiroglu pediatriccardiacsurgeryundercardiopulmonarybypassinfactorviideficiency AT zeynepeyileten pediatriccardiacsurgeryundercardiopulmonarybypassinfactorviideficiency AT tayfunucar pediatriccardiacsurgeryundercardiopulmonarybypassinfactorviideficiency AT talyaileri pediatriccardiacsurgeryundercardiopulmonarybypassinfactorviideficiency |