Gene polymorphisms of miR-323b and miR-1343 that regulate kininogen L are associated with schizophrenia susceptibility: A preliminary population‑based study
miR-SNP is a type of functional single nucleotide polymorphism (SNP) that affects the regulatory functions of miRNA genes, miRNA binding sites, or components of miRNA biogenesis. This study aimed to explore the relationship between miRNA gene polymorphisms that regulate the kininogen L protein and...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2024-10-01
|
| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://bjbms.org/ojs/index.php/bjbms/article/view/11100 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850195900405645312 |
|---|---|
| author | Xiaoyu Liu Mengdi Jin Mingjia Yang Lijuan Yan Weijiao Zhao Lizhuo Liu Hongmin Wang Yongzhuo Ding Yanyan Sun Yanchi Zhang Qiong Yu |
| author_facet | Xiaoyu Liu Mengdi Jin Mingjia Yang Lijuan Yan Weijiao Zhao Lizhuo Liu Hongmin Wang Yongzhuo Ding Yanyan Sun Yanchi Zhang Qiong Yu |
| author_sort | Xiaoyu Liu |
| collection | DOAJ |
| description |
miR-SNP is a type of functional single nucleotide polymorphism (SNP) that affects the regulatory functions of miRNA genes, miRNA binding sites, or components of miRNA biogenesis. This study aimed to explore the relationship between miRNA gene polymorphisms that regulate the kininogen L protein and schizophrenia (SCZ). Bioinformatics methods predicted miRNA gene polymorphism sites regulating the kininogen L protein. The polymorphisms of rs56103835, rs6513496, rs651349, and rs2986407 were detected using imLDR multiple SNP typing technologies in 513 SCZ patients and 509 controls. The association of miR-SNP variations with SCZ susceptibility and symptoms was evaluated using SNPstat to determine the optimal inheritance model. Generalized multifactor dimensionality reduction (GMDR) analysis and logistic regression were used to calculate miR-SNP interactions. The association between hsa-miR-323b-rs56103835 and SCZ was statistically significant under the dominant model. The result of gene-gene interaction showed that the three-factor model (rs56103835 / rs2986407 / rs2155248) was the best, but it could not be considered significantly related to SCZ. Additionally, SCZ patients with the CC or CT genotype on rs2986407 were more likely to experience auditory hallucinations than those with the TT genotype. Our data revealed that the mutation of hsa-miR-323b-rs56103835 from C to T was associated with susceptibility to SCZ. The mutation of hsa-miR-1343-rs2986407 from T to C increases the risk of auditory hallucinations in SCZ patients.
|
| format | Article |
| id | doaj-art-8d230e33edf441328e8fec036c9be838 |
| institution | OA Journals |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj-art-8d230e33edf441328e8fec036c9be8382025-08-20T02:13:36ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2024-10-0110.17305/bb.2024.11100Gene polymorphisms of miR-323b and miR-1343 that regulate kininogen L are associated with schizophrenia susceptibility: A preliminary population‑based studyXiaoyu Liu0Mengdi Jin1Mingjia Yang2Lijuan Yan3Weijiao Zhao4Lizhuo Liu5Hongmin Wang6Yongzhuo Ding7Yanyan Sun8Yanchi Zhang9Qiong Yu10Department of Psychology, Changchun Sixth Hospital, Changchun, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, ChinaDepartment of Psychology, Changchun Sixth Hospital, Changchun, ChinaDepartment of Psychology, Changchun Sixth Hospital, Changchun, ChinaDepartment of Psychology, Changchun Sixth Hospital, Changchun, ChinaDepartment of Psychology, Changchun Sixth Hospital, Changchun, ChinaDepartment of Psychology, Changchun Sixth Hospital, Changchun, ChinaDepartment of Psychology, Changchun Sixth Hospital, Changchun, ChinaDepartment of Psychology, Changchun Sixth Hospital, Changchun, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China miR-SNP is a type of functional single nucleotide polymorphism (SNP) that affects the regulatory functions of miRNA genes, miRNA binding sites, or components of miRNA biogenesis. This study aimed to explore the relationship between miRNA gene polymorphisms that regulate the kininogen L protein and schizophrenia (SCZ). Bioinformatics methods predicted miRNA gene polymorphism sites regulating the kininogen L protein. The polymorphisms of rs56103835, rs6513496, rs651349, and rs2986407 were detected using imLDR multiple SNP typing technologies in 513 SCZ patients and 509 controls. The association of miR-SNP variations with SCZ susceptibility and symptoms was evaluated using SNPstat to determine the optimal inheritance model. Generalized multifactor dimensionality reduction (GMDR) analysis and logistic regression were used to calculate miR-SNP interactions. The association between hsa-miR-323b-rs56103835 and SCZ was statistically significant under the dominant model. The result of gene-gene interaction showed that the three-factor model (rs56103835 / rs2986407 / rs2155248) was the best, but it could not be considered significantly related to SCZ. Additionally, SCZ patients with the CC or CT genotype on rs2986407 were more likely to experience auditory hallucinations than those with the TT genotype. Our data revealed that the mutation of hsa-miR-323b-rs56103835 from C to T was associated with susceptibility to SCZ. The mutation of hsa-miR-1343-rs2986407 from T to C increases the risk of auditory hallucinations in SCZ patients. https://bjbms.org/ojs/index.php/bjbms/article/view/11100Kininogen-LmiR-SNPschizophreniaauditory hallucinations |
| spellingShingle | Xiaoyu Liu Mengdi Jin Mingjia Yang Lijuan Yan Weijiao Zhao Lizhuo Liu Hongmin Wang Yongzhuo Ding Yanyan Sun Yanchi Zhang Qiong Yu Gene polymorphisms of miR-323b and miR-1343 that regulate kininogen L are associated with schizophrenia susceptibility: A preliminary population‑based study Biomolecules & Biomedicine Kininogen-L miR-SNP schizophrenia auditory hallucinations |
| title | Gene polymorphisms of miR-323b and miR-1343 that regulate kininogen L are associated with schizophrenia susceptibility: A preliminary population‑based study |
| title_full | Gene polymorphisms of miR-323b and miR-1343 that regulate kininogen L are associated with schizophrenia susceptibility: A preliminary population‑based study |
| title_fullStr | Gene polymorphisms of miR-323b and miR-1343 that regulate kininogen L are associated with schizophrenia susceptibility: A preliminary population‑based study |
| title_full_unstemmed | Gene polymorphisms of miR-323b and miR-1343 that regulate kininogen L are associated with schizophrenia susceptibility: A preliminary population‑based study |
| title_short | Gene polymorphisms of miR-323b and miR-1343 that regulate kininogen L are associated with schizophrenia susceptibility: A preliminary population‑based study |
| title_sort | gene polymorphisms of mir 323b and mir 1343 that regulate kininogen l are associated with schizophrenia susceptibility a preliminary population based study |
| topic | Kininogen-L miR-SNP schizophrenia auditory hallucinations |
| url | https://bjbms.org/ojs/index.php/bjbms/article/view/11100 |
| work_keys_str_mv | AT xiaoyuliu genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy AT mengdijin genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy AT mingjiayang genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy AT lijuanyan genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy AT weijiaozhao genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy AT lizhuoliu genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy AT hongminwang genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy AT yongzhuoding genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy AT yanyansun genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy AT yanchizhang genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy AT qiongyu genepolymorphismsofmir323bandmir1343thatregulatekininogenlareassociatedwithschizophreniasusceptibilityapreliminarypopulationbasedstudy |