Development of an acute lung injury model for drug testing

Development of an acute lung injury model for drug testing

Abstract A challenge that limits our understanding of the underlying pathobiology of pediatric acute respiratory distress syndrome (PARDS) is the lack of a preclinical airway model that can be leveraged for the study of mechanisms and specific molecules for drug testing. We developed a physiologic m...

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Bibliographic Details
Main Authors: Jocelyn R. Grunwell, Susan T. Stephenson, Gail A. Dallalio, Badiallo A. Diani, Celena Zaworski, Natalie Jordan, Anne M. Fitzpatrick
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Pediatric
Acute respiratory distress syndrome
Baricitinib
STAT3
Small airway epithelial cells
Model
Online Access:https://doi.org/10.1038/s41598-025-02078-9
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