Multifocal Intestinal Extranodal Marginal Zone Lymphoma Presenting With Autoimmune Hemolytic Anemia: A Case Report
Extranodal marginal zone lymphoma of the intestine is a rare, indolent non-Hodgkin lymphoma that often presents with nonspecific symptoms, making diagnosis challenging. We report a 74-year-old woman who presented with severe anemia attributable to autoimmune hemolytic anemia. Imaging revealed spleno...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2025-03-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.1222 |
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| author | Ali Emre Bardak Naci Senkal Kanan Nuriyev Alpay Medetalibeyoglu |
| author_facet | Ali Emre Bardak Naci Senkal Kanan Nuriyev Alpay Medetalibeyoglu |
| author_sort | Ali Emre Bardak |
| collection | DOAJ |
| description | Extranodal marginal zone lymphoma of the intestine is a rare, indolent non-Hodgkin lymphoma that often presents with nonspecific symptoms, making diagnosis challenging. We report a 74-year-old woman who presented with severe anemia attributable to autoimmune hemolytic anemia. Imaging revealed splenomegaly and intestinal wall thickening, whereas subsequent endoscopy showed ulcerated lesions in the ileocecal valve, transverse colon, and descending colon. Biopsy results confirmed extranodal marginal zone lymphoma. Treatment with the R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) regimen led to partial remission of the lymphoma and complete resolution of autoimmune hemolytic anemia. |
| format | Article |
| id | doaj-art-8d1ea64f4b4749fdb8f7eb514c3e7a5a |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-8d1ea64f4b4749fdb8f7eb514c3e7a5a2025-08-20T03:18:45ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-03-014310.7326/aimcc.2024.1222Multifocal Intestinal Extranodal Marginal Zone Lymphoma Presenting With Autoimmune Hemolytic Anemia: A Case ReportAli Emre Bardak0Naci Senkal1Kanan Nuriyev2Alpay Medetalibeyoglu31Department of Internal Medicine, St. Elizabeth's Medical Center, Boston, Massachusetts2Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey3Department of Gastroenterology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey2Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, TurkeyExtranodal marginal zone lymphoma of the intestine is a rare, indolent non-Hodgkin lymphoma that often presents with nonspecific symptoms, making diagnosis challenging. We report a 74-year-old woman who presented with severe anemia attributable to autoimmune hemolytic anemia. Imaging revealed splenomegaly and intestinal wall thickening, whereas subsequent endoscopy showed ulcerated lesions in the ileocecal valve, transverse colon, and descending colon. Biopsy results confirmed extranodal marginal zone lymphoma. Treatment with the R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) regimen led to partial remission of the lymphoma and complete resolution of autoimmune hemolytic anemia.https://www.acpjournals.org/doi/10.7326/aimcc.2024.1222 |
| spellingShingle | Ali Emre Bardak Naci Senkal Kanan Nuriyev Alpay Medetalibeyoglu Multifocal Intestinal Extranodal Marginal Zone Lymphoma Presenting With Autoimmune Hemolytic Anemia: A Case Report Annals of Internal Medicine: Clinical Cases |
| title | Multifocal Intestinal Extranodal Marginal Zone Lymphoma Presenting With Autoimmune Hemolytic Anemia: A Case Report |
| title_full | Multifocal Intestinal Extranodal Marginal Zone Lymphoma Presenting With Autoimmune Hemolytic Anemia: A Case Report |
| title_fullStr | Multifocal Intestinal Extranodal Marginal Zone Lymphoma Presenting With Autoimmune Hemolytic Anemia: A Case Report |
| title_full_unstemmed | Multifocal Intestinal Extranodal Marginal Zone Lymphoma Presenting With Autoimmune Hemolytic Anemia: A Case Report |
| title_short | Multifocal Intestinal Extranodal Marginal Zone Lymphoma Presenting With Autoimmune Hemolytic Anemia: A Case Report |
| title_sort | multifocal intestinal extranodal marginal zone lymphoma presenting with autoimmune hemolytic anemia a case report |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2024.1222 |
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