Strengthening the Effectiveness of the Candidate Influenza Vaccine by Combining Conserved Sequences of Hemagglutinin and M2 protein

The development of universal influenza vaccine - a vaccine directed to all subtypes of human influenza A viruses - is the really actual problem task. This paper presents the comparative characteristic of the specific activity of various recombinant proteins consisting of antigenic determinants of in...

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Main Authors: L. M. Tsybalova, L. A. Stepanova, R. Yu. Kotlyarov, E. A. Blokhina, M. A. Shuklina, E. S. Mardanova, A. V. Korotkov, M. V. Potapchuk, N. V. Ravin
Format: Article
Language:Russian
Published: Numikom LLC 2017-06-01
Series:Эпидемиология и вакцинопрофилактика
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Online Access:https://www.epidemvac.ru/jour/article/view/278
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author L. M. Tsybalova
L. A. Stepanova
R. Yu. Kotlyarov
E. A. Blokhina
M. A. Shuklina
E. S. Mardanova
A. V. Korotkov
M. V. Potapchuk
N. V. Ravin
author_facet L. M. Tsybalova
L. A. Stepanova
R. Yu. Kotlyarov
E. A. Blokhina
M. A. Shuklina
E. S. Mardanova
A. V. Korotkov
M. V. Potapchuk
N. V. Ravin
author_sort L. M. Tsybalova
collection DOAJ
description The development of universal influenza vaccine - a vaccine directed to all subtypes of human influenza A viruses - is the really actual problem task. This paper presents the comparative characteristic of the specific activity of various recombinant proteins consisting of antigenic determinants of influenza A virus - the ectodomain of the M2 protein (M2e) and a fragment of the second subunit of the hemagglutinin (the amino acid sequence 76 - 130). Flagellin - Salmonella typhimurium protein was used as carrier protein and as adjuvant. We use two forms of flagellin: full size and with deleted hypervariable region. The proteins showed high immunogenicity, and the ability to prevent lethal infection of influenza virus in mice. Full-length flagellin with HA2 (76 - 130) and M2e on the C-terminus (protein Flg-HA2-4M2e) demonstrated the most protective properties. It provides 100% survival immunized mice that were challenge with a high dose of influenza A (H3N2) - 10 LD50. Proteins containing only full sized flagellin with M2e or flagellin truncated form with M2e at the C-terminus and HA2 within the hypervariable region, protected 75% of animals from lethal infection. Protein Flg-HA2-4M2e is promising for further study as a vaccine.
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language Russian
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series Эпидемиология и вакцинопрофилактика
spelling doaj-art-8d1cf5003b634a79bd2df95b18cf0ba72025-08-20T03:21:19ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942017-06-01163657010.31631/2073-3046-2017-16-3-65-70277Strengthening the Effectiveness of the Candidate Influenza Vaccine by Combining Conserved Sequences of Hemagglutinin and M2 proteinL. M. Tsybalova0L. A. Stepanova1R. Yu. Kotlyarov2E. A. Blokhina3M. A. Shuklina4E. S. Mardanova5A. V. Korotkov6M. V. Potapchuk7N. V. Ravin8Federal State Budget Institution Research «Institute of Influenza» of the Ministry of Healthcare of the Russian FederationFederal State Budget Institution Research «Institute of Influenza» of the Ministry of Healthcare of the Russian FederationFederal State Institution «The Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of SciencesFederal State Institution «The Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of SciencesFederal State Budget Institution Research «Institute of Influenza» of the Ministry of Healthcare of the Russian FederationFederal State Institution «The Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of SciencesFederal State Budget Institution Research «Institute of Influenza» of the Ministry of Healthcare of the Russian FederationFederal State Budget Institution Research «Institute of Influenza» of the Ministry of Healthcare of the Russian FederationFederal State Institution «The Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of SciencesThe development of universal influenza vaccine - a vaccine directed to all subtypes of human influenza A viruses - is the really actual problem task. This paper presents the comparative characteristic of the specific activity of various recombinant proteins consisting of antigenic determinants of influenza A virus - the ectodomain of the M2 protein (M2e) and a fragment of the second subunit of the hemagglutinin (the amino acid sequence 76 - 130). Flagellin - Salmonella typhimurium protein was used as carrier protein and as adjuvant. We use two forms of flagellin: full size and with deleted hypervariable region. The proteins showed high immunogenicity, and the ability to prevent lethal infection of influenza virus in mice. Full-length flagellin with HA2 (76 - 130) and M2e on the C-terminus (protein Flg-HA2-4M2e) demonstrated the most protective properties. It provides 100% survival immunized mice that were challenge with a high dose of influenza A (H3N2) - 10 LD50. Proteins containing only full sized flagellin with M2e or flagellin truncated form with M2e at the C-terminus and HA2 within the hypervariable region, protected 75% of animals from lethal infection. Protein Flg-HA2-4M2e is promising for further study as a vaccine.https://www.epidemvac.ru/jour/article/view/278гриппвакцинациярекомбинантный белокиммуногенностьпротективностьinfluenzavaccinationrecombinant proteinimmunogenicityprotection
spellingShingle L. M. Tsybalova
L. A. Stepanova
R. Yu. Kotlyarov
E. A. Blokhina
M. A. Shuklina
E. S. Mardanova
A. V. Korotkov
M. V. Potapchuk
N. V. Ravin
Strengthening the Effectiveness of the Candidate Influenza Vaccine by Combining Conserved Sequences of Hemagglutinin and M2 protein
Эпидемиология и вакцинопрофилактика
грипп
вакцинация
рекомбинантный белок
иммуногенность
протективность
influenza
vaccination
recombinant protein
immunogenicity
protection
title Strengthening the Effectiveness of the Candidate Influenza Vaccine by Combining Conserved Sequences of Hemagglutinin and M2 protein
title_full Strengthening the Effectiveness of the Candidate Influenza Vaccine by Combining Conserved Sequences of Hemagglutinin and M2 protein
title_fullStr Strengthening the Effectiveness of the Candidate Influenza Vaccine by Combining Conserved Sequences of Hemagglutinin and M2 protein
title_full_unstemmed Strengthening the Effectiveness of the Candidate Influenza Vaccine by Combining Conserved Sequences of Hemagglutinin and M2 protein
title_short Strengthening the Effectiveness of the Candidate Influenza Vaccine by Combining Conserved Sequences of Hemagglutinin and M2 protein
title_sort strengthening the effectiveness of the candidate influenza vaccine by combining conserved sequences of hemagglutinin and m2 protein
topic грипп
вакцинация
рекомбинантный белок
иммуногенность
протективность
influenza
vaccination
recombinant protein
immunogenicity
protection
url https://www.epidemvac.ru/jour/article/view/278
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AT avkorotkov strengtheningtheeffectivenessofthecandidateinfluenzavaccinebycombiningconservedsequencesofhemagglutininandm2protein
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