Disorder of phospholipid metabolism in the renal cortex and medulla contributes to acute tubular necrosis in mice after cantharidin exposure using integrative lipidomics and spatial metabolomics

Disorder of phospholipid metabolism in the renal cortex and medulla contributes to acute tubular necrosis in mice after cantharidin exposure using integrative lipidomics and spatial metabolomics

Cantharidin (CTD), a natural compound used to treat multiple tumors in the clinic setting, has been limited due to acute kidney injury (AKI). However, the major cause of AKI and its underlying mechanism remain to be elucidated. Serum creatinine (SCr) and blood urea nitrogen (BUN) were detected throu...

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Bibliographic Details
Main Authors: Tianmu He, Kexin Lin, Lijuan Xiong, Wen Zhang, Huan Zhang, Cancan Duan, Xiaofei Li, Jianyong Zhang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Acute kidney injury
Acute tubular necrosis
Cantharidin
Glycerophospholipid metabolism
Spatial metabolomics
Sphingolipid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177925000279
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