Enantioseparation of organometallic compounds and metal complexes by liquid chromatographic techniques. A review
Chiral organometallic compounds and metal complexes, and more recently metal clusters, have attracted great interest for applications in chemical, biological, medical, and material sciences. In these fields, liquid chromatography has been widely used for fast chiral analysis to determine the enantio...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-11-01
|
| Series: | Journal of Chromatography Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772391724000343 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850111043897917440 |
|---|---|
| author | Barbara Sechi Sergio Cossu Paola Peluso |
| author_facet | Barbara Sechi Sergio Cossu Paola Peluso |
| author_sort | Barbara Sechi |
| collection | DOAJ |
| description | Chiral organometallic compounds and metal complexes, and more recently metal clusters, have attracted great interest for applications in chemical, biological, medical, and material sciences. In these fields, liquid chromatography has been widely used for fast chiral analysis to determine the enantiomeric purity of metal-containing chiral compounds prepared by asymmetric synthesis, for quality control of commercial chiral metal catalysts, for accessing enantioenriched or pure enantiomers of metal complexes for various applications, and often as test probe analytes for screening the enantioseparation capability of newly developed chiral columns and chromatographic systems. With the aim to show what was done in this field as a useful guide for new applications, in this review the evolution of methods and approaches used to separate the enantiomers of chiral metal-containing compounds is described, showing how this field have been changed over time, from the 1970s until most recent studies. For this purpose, representative applications of enantioselective liquid chromatography for the enantioseparation of chiral organometallic compounds and metal complexes will be presented and discussed, indicating chiral columns, mobile phases, and chromatographic conditions which have been used to obtain successful enantioseparations in this field. |
| format | Article |
| id | doaj-art-8d175a2efe3649a2a12d9c1272e06964 |
| institution | OA Journals |
| issn | 2772-3917 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Chromatography Open |
| spelling | doaj-art-8d175a2efe3649a2a12d9c1272e069642025-08-20T02:37:42ZengElsevierJournal of Chromatography Open2772-39172024-11-01610014710.1016/j.jcoa.2024.100147Enantioseparation of organometallic compounds and metal complexes by liquid chromatographic techniques. A reviewBarbara Sechi0Sergio Cossu1Paola Peluso2Istituto di Chimica Biomolecolare ICB, CNR, Sede secondaria di Sassari, Traversa La Crucca 3, I-07100 Li Punti - Sassari, ItalyDipartimento di Scienze Molecolari e Nanosistemi DSMN, Università Ca’ Foscari Venezia, Via Torino 155, I-30172 Mestre Venezia, ItalyIstituto di Chimica Biomolecolare ICB, CNR, Sede secondaria di Sassari, Traversa La Crucca 3, I-07100 Li Punti - Sassari, Italy; Corresponding author.Chiral organometallic compounds and metal complexes, and more recently metal clusters, have attracted great interest for applications in chemical, biological, medical, and material sciences. In these fields, liquid chromatography has been widely used for fast chiral analysis to determine the enantiomeric purity of metal-containing chiral compounds prepared by asymmetric synthesis, for quality control of commercial chiral metal catalysts, for accessing enantioenriched or pure enantiomers of metal complexes for various applications, and often as test probe analytes for screening the enantioseparation capability of newly developed chiral columns and chromatographic systems. With the aim to show what was done in this field as a useful guide for new applications, in this review the evolution of methods and approaches used to separate the enantiomers of chiral metal-containing compounds is described, showing how this field have been changed over time, from the 1970s until most recent studies. For this purpose, representative applications of enantioselective liquid chromatography for the enantioseparation of chiral organometallic compounds and metal complexes will be presented and discussed, indicating chiral columns, mobile phases, and chromatographic conditions which have been used to obtain successful enantioseparations in this field.http://www.sciencedirect.com/science/article/pii/S2772391724000343Chiral stationary phasesEnantioseparationHigh-performance liquid-chromatographyPolysaccharide-based chiral selectorsTransition metal complexes |
| spellingShingle | Barbara Sechi Sergio Cossu Paola Peluso Enantioseparation of organometallic compounds and metal complexes by liquid chromatographic techniques. A review Journal of Chromatography Open Chiral stationary phases Enantioseparation High-performance liquid-chromatography Polysaccharide-based chiral selectors Transition metal complexes |
| title | Enantioseparation of organometallic compounds and metal complexes by liquid chromatographic techniques. A review |
| title_full | Enantioseparation of organometallic compounds and metal complexes by liquid chromatographic techniques. A review |
| title_fullStr | Enantioseparation of organometallic compounds and metal complexes by liquid chromatographic techniques. A review |
| title_full_unstemmed | Enantioseparation of organometallic compounds and metal complexes by liquid chromatographic techniques. A review |
| title_short | Enantioseparation of organometallic compounds and metal complexes by liquid chromatographic techniques. A review |
| title_sort | enantioseparation of organometallic compounds and metal complexes by liquid chromatographic techniques a review |
| topic | Chiral stationary phases Enantioseparation High-performance liquid-chromatography Polysaccharide-based chiral selectors Transition metal complexes |
| url | http://www.sciencedirect.com/science/article/pii/S2772391724000343 |
| work_keys_str_mv | AT barbarasechi enantioseparationoforganometalliccompoundsandmetalcomplexesbyliquidchromatographictechniquesareview AT sergiocossu enantioseparationoforganometalliccompoundsandmetalcomplexesbyliquidchromatographictechniquesareview AT paolapeluso enantioseparationoforganometalliccompoundsandmetalcomplexesbyliquidchromatographictechniquesareview |