Inflammatory indexes and anemia in chronic kidney disease: correlation and survival analysis of the National Health and Nutrition Examination Survey 2005–2018
Background There is currently no research on the correlation between novel inflammatory indexes systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the risk of anemia in chronic kidney disease (CKD) population, as well as survival a...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2399314 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849763485484843008 |
|---|---|
| author | Shaojie Fu Jingda Huang Zhenbang Feng Haitao Wang Hongzhao Xu Meiyan Wu Fuzhe Ma Zhonggao Xu |
| author_facet | Shaojie Fu Jingda Huang Zhenbang Feng Haitao Wang Hongzhao Xu Meiyan Wu Fuzhe Ma Zhonggao Xu |
| author_sort | Shaojie Fu |
| collection | DOAJ |
| description | Background There is currently no research on the correlation between novel inflammatory indexes systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the risk of anemia in chronic kidney disease (CKD) population, as well as survival analysis in CKD with anemia.Methods This investigation encompassed 4444 adult subjects out of the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. The study utilized multi-variable logistic regression to assess the relationship between SII, NLR, PLR, and anemia risk occurrence in CKD population. Survival differences in CKD patients with anemia, based on varying levels of SII, NLR, and PLR were evaluated employing Kaplan–Meier and Cox proportional hazards models.Results The adjusted logistic regression model demonstrates that SII, NLR, and PLR are associated with the risk of anemia occurrence in CKD population. Kaplan–Meier’s analysis reveals significant differences in survival rates among CKD patients with anemia stratified by NLR levels. The adjusted Cox proportional hazards model shows that the higher NLR group has a 30% elevated risk of all-cause mortality contrasted with lower group (hazard ratio, HR: 1.30, confidence interval (CI) [1.01, 1.66], p value <.04). Restricted cubic spline (RCS) demonstrates no nonlinear relationship between NLR and all-cause mortality. Lastly, sub-cohort analysis indicates that in populations with diabetes, hypertension, and hyperuricemia, NLR levels have a greater impact on all-cause mortality.Conclusions Controlling inflammation may reduce the occurrence of anemia in CKD populations, with NLR serving to be a potential prognostic indicator for survival results within CKD patients suffering from co-morbid anemia. |
| format | Article |
| id | doaj-art-8d16c67c87e14fb1abac8fb2852c5e50 |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-8d16c67c87e14fb1abac8fb2852c5e502025-08-20T03:05:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2399314Inflammatory indexes and anemia in chronic kidney disease: correlation and survival analysis of the National Health and Nutrition Examination Survey 2005–2018Shaojie Fu0Jingda Huang1Zhenbang Feng2Haitao Wang3Hongzhao Xu4Meiyan Wu5Fuzhe Ma6Zhonggao Xu7Department of Nephrology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Nephrology, The First Hospital of Jilin University, Changchun, ChinaCenter of Oncology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Critical Care Medicine, The First Hospital of Jilin University, Changchun, ChinaDepartment of Nephrology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Nephrology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Nephrology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Nephrology, The First Hospital of Jilin University, Changchun, ChinaBackground There is currently no research on the correlation between novel inflammatory indexes systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the risk of anemia in chronic kidney disease (CKD) population, as well as survival analysis in CKD with anemia.Methods This investigation encompassed 4444 adult subjects out of the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. The study utilized multi-variable logistic regression to assess the relationship between SII, NLR, PLR, and anemia risk occurrence in CKD population. Survival differences in CKD patients with anemia, based on varying levels of SII, NLR, and PLR were evaluated employing Kaplan–Meier and Cox proportional hazards models.Results The adjusted logistic regression model demonstrates that SII, NLR, and PLR are associated with the risk of anemia occurrence in CKD population. Kaplan–Meier’s analysis reveals significant differences in survival rates among CKD patients with anemia stratified by NLR levels. The adjusted Cox proportional hazards model shows that the higher NLR group has a 30% elevated risk of all-cause mortality contrasted with lower group (hazard ratio, HR: 1.30, confidence interval (CI) [1.01, 1.66], p value <.04). Restricted cubic spline (RCS) demonstrates no nonlinear relationship between NLR and all-cause mortality. Lastly, sub-cohort analysis indicates that in populations with diabetes, hypertension, and hyperuricemia, NLR levels have a greater impact on all-cause mortality.Conclusions Controlling inflammation may reduce the occurrence of anemia in CKD populations, with NLR serving to be a potential prognostic indicator for survival results within CKD patients suffering from co-morbid anemia.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2399314Systemic immune-inflammation indexneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiochronic kidney diseaseanemiaNHANES |
| spellingShingle | Shaojie Fu Jingda Huang Zhenbang Feng Haitao Wang Hongzhao Xu Meiyan Wu Fuzhe Ma Zhonggao Xu Inflammatory indexes and anemia in chronic kidney disease: correlation and survival analysis of the National Health and Nutrition Examination Survey 2005–2018 Renal Failure Systemic immune-inflammation index neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio chronic kidney disease anemia NHANES |
| title | Inflammatory indexes and anemia in chronic kidney disease: correlation and survival analysis of the National Health and Nutrition Examination Survey 2005–2018 |
| title_full | Inflammatory indexes and anemia in chronic kidney disease: correlation and survival analysis of the National Health and Nutrition Examination Survey 2005–2018 |
| title_fullStr | Inflammatory indexes and anemia in chronic kidney disease: correlation and survival analysis of the National Health and Nutrition Examination Survey 2005–2018 |
| title_full_unstemmed | Inflammatory indexes and anemia in chronic kidney disease: correlation and survival analysis of the National Health and Nutrition Examination Survey 2005–2018 |
| title_short | Inflammatory indexes and anemia in chronic kidney disease: correlation and survival analysis of the National Health and Nutrition Examination Survey 2005–2018 |
| title_sort | inflammatory indexes and anemia in chronic kidney disease correlation and survival analysis of the national health and nutrition examination survey 2005 2018 |
| topic | Systemic immune-inflammation index neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio chronic kidney disease anemia NHANES |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2399314 |
| work_keys_str_mv | AT shaojiefu inflammatoryindexesandanemiainchronickidneydiseasecorrelationandsurvivalanalysisofthenationalhealthandnutritionexaminationsurvey20052018 AT jingdahuang inflammatoryindexesandanemiainchronickidneydiseasecorrelationandsurvivalanalysisofthenationalhealthandnutritionexaminationsurvey20052018 AT zhenbangfeng inflammatoryindexesandanemiainchronickidneydiseasecorrelationandsurvivalanalysisofthenationalhealthandnutritionexaminationsurvey20052018 AT haitaowang inflammatoryindexesandanemiainchronickidneydiseasecorrelationandsurvivalanalysisofthenationalhealthandnutritionexaminationsurvey20052018 AT hongzhaoxu inflammatoryindexesandanemiainchronickidneydiseasecorrelationandsurvivalanalysisofthenationalhealthandnutritionexaminationsurvey20052018 AT meiyanwu inflammatoryindexesandanemiainchronickidneydiseasecorrelationandsurvivalanalysisofthenationalhealthandnutritionexaminationsurvey20052018 AT fuzhema inflammatoryindexesandanemiainchronickidneydiseasecorrelationandsurvivalanalysisofthenationalhealthandnutritionexaminationsurvey20052018 AT zhonggaoxu inflammatoryindexesandanemiainchronickidneydiseasecorrelationandsurvivalanalysisofthenationalhealthandnutritionexaminationsurvey20052018 |