Global incidence, risk factors, and temporal trends of nasal cancer: A population‐based analysis
Abstract Background Nasal cancer is a rare and fatal disease, with an incidence rate of <1 in 100,000, and a 5‐year survival rate of around 30%. The study aims to investigate the worldwide disease burden, associated risk factors, and temporal incidence patterns of nasal cancer. Methods Data were...
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Wiley
2025-04-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70163 |
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| author | Junjie Huang Wing Sze Pang Fung Yu Mak Sze Chai Chan Veeleah Lok Lin Zhang Xu Lin Don Eliseo Lucero‐Prisno III Wanghong Xu Zhi‐Jie Zheng Edmar Elcarte Mellissa Withers Martin C. S. Wong NCD Global Health Research Group, Association of Pacific Rim Universities (APRU) |
| author_facet | Junjie Huang Wing Sze Pang Fung Yu Mak Sze Chai Chan Veeleah Lok Lin Zhang Xu Lin Don Eliseo Lucero‐Prisno III Wanghong Xu Zhi‐Jie Zheng Edmar Elcarte Mellissa Withers Martin C. S. Wong NCD Global Health Research Group, Association of Pacific Rim Universities (APRU) |
| author_sort | Junjie Huang |
| collection | DOAJ |
| description | Abstract Background Nasal cancer is a rare and fatal disease, with an incidence rate of <1 in 100,000, and a 5‐year survival rate of around 30%. The study aims to investigate the worldwide disease burden, associated risk factors, and temporal incidence patterns of nasal cancer. Methods Data were obtained from multiple sources, including the Global Cancer Observatory, Cancer Incidence in Five Continents Plus, the Global Burden of Disease database, the World Bank, and the United Nations. The study utilized multivariable linear regression to investigate the relationship between risk factors and the incidence of nasal cancer by age for each country. Trend analysis was conducted using the joinpoint regression analysis program, and the average annual percentage change (AAPC) was calculated. The accuracy of trend estimations was assessed using the 95% confidence interval (CI). Additionally, the incidence of nasal cancer was examined by age and geographic location. Results A total of 37,674 new cases were reported in 2020 (ASR 4.2 per 1,000,000). The highest ASRs were observed in South‐Eastern Asia (5.3) and Central and Eastern Europe (4.8). A number of risk factors were identified, such as higher HDI regions, higher prevalence of smoking, alcohol drinking, unhealthy dietary, and hypertension. In addition, physical inactivity was related to lower incidence. An overall decreasing trend was reported in the global population, but an increasing trend was discovered in males. Conclusions The highest burden of nasal cancer was found in South‐Eastern Asia and Central and Eastern Europe, potentially due to regional genetic factors and pollution issues. Targeted interventions are need in high‐risk regions. Further studies are needed to investigate factors contributing to the increasing temporal trend of nasal cancer among the male population. |
| format | Article |
| id | doaj-art-8d153310e5144089bb7b60313168394f |
| institution | OA Journals |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-8d153310e5144089bb7b60313168394f2025-08-20T02:18:35ZengWileyCancer Medicine2045-76342025-04-01148n/an/a10.1002/cam4.70163Global incidence, risk factors, and temporal trends of nasal cancer: A population‐based analysisJunjie Huang0Wing Sze Pang1Fung Yu Mak2Sze Chai Chan3Veeleah Lok4Lin Zhang5Xu Lin6Don Eliseo Lucero‐Prisno III7Wanghong Xu8Zhi‐Jie Zheng9Edmar Elcarte10Mellissa Withers11Martin C. S. Wong12NCD Global Health Research Group, Association of Pacific Rim Universities (APRU)The Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong Hong Kong SAR ChinaThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong Hong Kong SAR ChinaThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong Hong Kong SAR ChinaThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong Hong Kong SAR ChinaDepartment of Global Public Health Karolinska Institute, Karolinska University Hospital Stockholm SwedenSuzhou Industrial Park Monash Research Institute of Science and Technology Suzhou ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital, School of Medicine Zhejiang University Zhejiang Hangzhou ChinaDepartment of Global Health and Development London School of Hygiene and Tropical Medicine London UKSchool of Public Health, Fudan University Shanghai ChinaDepartment of Global Health School of Public Health, Peking University Beijing ChinaUniversity of the Philippines Manila PhilippinesDepartment of Population and Health Sciences Institute for Global Health, University of Southern California Los Angeles California USAThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong Hong Kong SAR ChinaAbstract Background Nasal cancer is a rare and fatal disease, with an incidence rate of <1 in 100,000, and a 5‐year survival rate of around 30%. The study aims to investigate the worldwide disease burden, associated risk factors, and temporal incidence patterns of nasal cancer. Methods Data were obtained from multiple sources, including the Global Cancer Observatory, Cancer Incidence in Five Continents Plus, the Global Burden of Disease database, the World Bank, and the United Nations. The study utilized multivariable linear regression to investigate the relationship between risk factors and the incidence of nasal cancer by age for each country. Trend analysis was conducted using the joinpoint regression analysis program, and the average annual percentage change (AAPC) was calculated. The accuracy of trend estimations was assessed using the 95% confidence interval (CI). Additionally, the incidence of nasal cancer was examined by age and geographic location. Results A total of 37,674 new cases were reported in 2020 (ASR 4.2 per 1,000,000). The highest ASRs were observed in South‐Eastern Asia (5.3) and Central and Eastern Europe (4.8). A number of risk factors were identified, such as higher HDI regions, higher prevalence of smoking, alcohol drinking, unhealthy dietary, and hypertension. In addition, physical inactivity was related to lower incidence. An overall decreasing trend was reported in the global population, but an increasing trend was discovered in males. Conclusions The highest burden of nasal cancer was found in South‐Eastern Asia and Central and Eastern Europe, potentially due to regional genetic factors and pollution issues. Targeted interventions are need in high‐risk regions. Further studies are needed to investigate factors contributing to the increasing temporal trend of nasal cancer among the male population.https://doi.org/10.1002/cam4.70163incidencenasal cancerrisk factorstemporal trend |
| spellingShingle | Junjie Huang Wing Sze Pang Fung Yu Mak Sze Chai Chan Veeleah Lok Lin Zhang Xu Lin Don Eliseo Lucero‐Prisno III Wanghong Xu Zhi‐Jie Zheng Edmar Elcarte Mellissa Withers Martin C. S. Wong NCD Global Health Research Group, Association of Pacific Rim Universities (APRU) Global incidence, risk factors, and temporal trends of nasal cancer: A population‐based analysis Cancer Medicine incidence nasal cancer risk factors temporal trend |
| title | Global incidence, risk factors, and temporal trends of nasal cancer: A population‐based analysis |
| title_full | Global incidence, risk factors, and temporal trends of nasal cancer: A population‐based analysis |
| title_fullStr | Global incidence, risk factors, and temporal trends of nasal cancer: A population‐based analysis |
| title_full_unstemmed | Global incidence, risk factors, and temporal trends of nasal cancer: A population‐based analysis |
| title_short | Global incidence, risk factors, and temporal trends of nasal cancer: A population‐based analysis |
| title_sort | global incidence risk factors and temporal trends of nasal cancer a population based analysis |
| topic | incidence nasal cancer risk factors temporal trend |
| url | https://doi.org/10.1002/cam4.70163 |
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