Analysis of the effectiveness of primary treatment of stage IA–IIA ovarian cancer
Aim: to determine the effectiveness of primary treatment of patients with ovarian cancer of stages IA–IIA.Material and Methods. The study included 336 (100 %) patients with histologically confrmed ovarian cancer of stages IA–IIA, who were treated at the Primorsky Regional Oncology Center from 2004 t...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2024-11-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/3262 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849252219513208832 |
|---|---|
| author | V. N. Zhurman V. M. Nechushkina |
| author_facet | V. N. Zhurman V. M. Nechushkina |
| author_sort | V. N. Zhurman |
| collection | DOAJ |
| description | Aim: to determine the effectiveness of primary treatment of patients with ovarian cancer of stages IA–IIA.Material and Methods. The study included 336 (100 %) patients with histologically confrmed ovarian cancer of stages IA–IIA, who were treated at the Primorsky Regional Oncology Center from 2004 to 2021. The overall survival (s) and progression-free survival (PFS) were analyzed depending on clinical and morphological factors: histological type of cancer, BRCA1/2 mutation, profle of the clinic where surgical treatment was performed, surgical staging and chemotherapy option. The examination for a mutation in the BRCA1/2 gene was performed by a new generation sequencing method. The data were statistically processed using the IBM SPSS Statistics 26 program.Results. The average age of patients with stage IA–IIA ovarian cancer was 52.12 ± 12.13 years. Statistically signifcantly higher survival rates were in patients with histological tumor type low-grade serous carcinoma compared with high-grade serous carcinoma (S: p=0.010 and IBP: p=0.020), with surgical treatment in specialized hospitals compared with patients operated in gynecological hospitals (s: p=0.040 and IBP: p=0.020), during adequate surgical staging (OV: p=0.008 and IBP: p=0.010), during treatment with platinum and taxanes (OV: p=0.001 and IBP: p=0.001).Conclusion. It was shown that about 30 % of patients with stage IA–IIA ovarian cancer in Primorsky Krai received primary surgical treatment in non-specialized hospitals, which increased the risk of progression and death by 1.7 times. A low percentage of adequate surgical staging was noted (12.5 %). Adjuvant chemotherapy with platinum and non-oxane agents worsened the prognosis of the disease. Patients with low-grade serous carcinoma had a more favorable prognosis (by 60 %). There was no statistically signifcant effect of the presence of a mutation in the BRCA1/2 genes on survival rates. |
| format | Article |
| id | doaj-art-8d1309f47c4c4b7b87e26e669141f919 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2024-11-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-8d1309f47c4c4b7b87e26e669141f9192025-08-20T03:56:41ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682024-11-01235172510.21294/1814-4861-2024-23-5-17-251267Analysis of the effectiveness of primary treatment of stage IA–IIA ovarian cancerV. N. Zhurman0V. M. Nechushkina1Primorsky Regional Cancer Center; Pacifc State Medical University of the Ministry of Health of RussiaScientifc and Educational Center “Eurasian Cancer Program” EAFO; Privolzhsky Research Medical University of the Ministry of Health of RussiaAim: to determine the effectiveness of primary treatment of patients with ovarian cancer of stages IA–IIA.Material and Methods. The study included 336 (100 %) patients with histologically confrmed ovarian cancer of stages IA–IIA, who were treated at the Primorsky Regional Oncology Center from 2004 to 2021. The overall survival (s) and progression-free survival (PFS) were analyzed depending on clinical and morphological factors: histological type of cancer, BRCA1/2 mutation, profle of the clinic where surgical treatment was performed, surgical staging and chemotherapy option. The examination for a mutation in the BRCA1/2 gene was performed by a new generation sequencing method. The data were statistically processed using the IBM SPSS Statistics 26 program.Results. The average age of patients with stage IA–IIA ovarian cancer was 52.12 ± 12.13 years. Statistically signifcantly higher survival rates were in patients with histological tumor type low-grade serous carcinoma compared with high-grade serous carcinoma (S: p=0.010 and IBP: p=0.020), with surgical treatment in specialized hospitals compared with patients operated in gynecological hospitals (s: p=0.040 and IBP: p=0.020), during adequate surgical staging (OV: p=0.008 and IBP: p=0.010), during treatment with platinum and taxanes (OV: p=0.001 and IBP: p=0.001).Conclusion. It was shown that about 30 % of patients with stage IA–IIA ovarian cancer in Primorsky Krai received primary surgical treatment in non-specialized hospitals, which increased the risk of progression and death by 1.7 times. A low percentage of adequate surgical staging was noted (12.5 %). Adjuvant chemotherapy with platinum and non-oxane agents worsened the prognosis of the disease. Patients with low-grade serous carcinoma had a more favorable prognosis (by 60 %). There was no statistically signifcant effect of the presence of a mutation in the BRCA1/2 genes on survival rates.https://www.siboncoj.ru/jour/article/view/3262ovarian cancerstage ia–iiasurgical stagingprimary treatment |
| spellingShingle | V. N. Zhurman V. M. Nechushkina Analysis of the effectiveness of primary treatment of stage IA–IIA ovarian cancer Сибирский онкологический журнал ovarian cancer stage ia–iia surgical staging primary treatment |
| title | Analysis of the effectiveness of primary treatment of stage IA–IIA ovarian cancer |
| title_full | Analysis of the effectiveness of primary treatment of stage IA–IIA ovarian cancer |
| title_fullStr | Analysis of the effectiveness of primary treatment of stage IA–IIA ovarian cancer |
| title_full_unstemmed | Analysis of the effectiveness of primary treatment of stage IA–IIA ovarian cancer |
| title_short | Analysis of the effectiveness of primary treatment of stage IA–IIA ovarian cancer |
| title_sort | analysis of the effectiveness of primary treatment of stage ia iia ovarian cancer |
| topic | ovarian cancer stage ia–iia surgical staging primary treatment |
| url | https://www.siboncoj.ru/jour/article/view/3262 |
| work_keys_str_mv | AT vnzhurman analysisoftheeffectivenessofprimarytreatmentofstageiaiiaovariancancer AT vmnechushkina analysisoftheeffectivenessofprimarytreatmentofstageiaiiaovariancancer |