Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatments
Apoptosis is a crucial process to maintain the correct balance between healthy cells and committed-to-death cells in every tissue. The internal (or mitochondrial) and external (or death receptor) pathways are responsible for driving a series of molecular events that lead to apoptosis by releasing pr...
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| Language: | English |
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Open Exploration
2024-11-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100874/100874.pdf |
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| author | Andrea Venerando Denise Lovison Rossella De Marco |
| author_facet | Andrea Venerando Denise Lovison Rossella De Marco |
| author_sort | Andrea Venerando |
| collection | DOAJ |
| description | Apoptosis is a crucial process to maintain the correct balance between healthy cells and committed-to-death cells in every tissue. The internal (or mitochondrial) and external (or death receptor) pathways are responsible for driving a series of molecular events that lead to apoptosis by releasing pro-apoptotic proteins, such as B-cell lymphoma-2 (BCL-2) homology 3 (BH3)-only proteins and second mitochondria-derived activator of caspases/diablo inhibitor of apoptosis protein-binding mitochondrial protein (SMAC/DIABLO), that in turn activate the caspase family of proteases. By counterbalancing the apoptogenic machinery, anti-apoptotic BCL-2 family members turn off pro-apoptotic signalling, favouring cell survival, a circumstance that is particularly pronounced in tumour cells in which apoptosis is deranged. Therefore, targeting the defective apoptotic process has become a viable therapeutic option for the treatment of several cancers and much effort is being made in the research and development of effective compounds. This review discussed and updated the most promising therapeutic strategies that target deranged apoptosis process in cancer by mimicking the pro-apoptotic effects of BH3-only and SMAC/DIABLO proteins. |
| format | Article |
| id | doaj-art-8d0e7e074ea94864a6402ef394a2f538 |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-8d0e7e074ea94864a6402ef394a2f5382025-02-08T03:28:18ZengOpen ExplorationExploration of Drug Science2836-76772024-11-012678581310.37349/eds.2024.00074Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatmentsAndrea Venerando0https://orcid.org/0000-0003-0379-2309Denise Lovison1https://orcid.org/0000-0002-1037-7384Rossella De Marco2https://orcid.org/0000-0001-7545-5921Department of Agricultural, Food, Environmental and Animal Sciences, University of Udine, 33100 Udine, ItalyDepartment of Agricultural, Food, Environmental and Animal Sciences, University of Udine, 33100 Udine, ItalyDepartment of Agricultural, Food, Environmental and Animal Sciences, University of Udine, 33100 Udine, ItalyApoptosis is a crucial process to maintain the correct balance between healthy cells and committed-to-death cells in every tissue. The internal (or mitochondrial) and external (or death receptor) pathways are responsible for driving a series of molecular events that lead to apoptosis by releasing pro-apoptotic proteins, such as B-cell lymphoma-2 (BCL-2) homology 3 (BH3)-only proteins and second mitochondria-derived activator of caspases/diablo inhibitor of apoptosis protein-binding mitochondrial protein (SMAC/DIABLO), that in turn activate the caspase family of proteases. By counterbalancing the apoptogenic machinery, anti-apoptotic BCL-2 family members turn off pro-apoptotic signalling, favouring cell survival, a circumstance that is particularly pronounced in tumour cells in which apoptosis is deranged. Therefore, targeting the defective apoptotic process has become a viable therapeutic option for the treatment of several cancers and much effort is being made in the research and development of effective compounds. This review discussed and updated the most promising therapeutic strategies that target deranged apoptosis process in cancer by mimicking the pro-apoptotic effects of BH3-only and SMAC/DIABLO proteins.https://www.explorationpub.com/uploads/Article/A100874/100874.pdfapoptosisbh3-mimeticssmac/diablokinase inhibitionpeptidomimeticsnanoparticles |
| spellingShingle | Andrea Venerando Denise Lovison Rossella De Marco Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatments Exploration of Drug Science apoptosis bh3-mimetics smac/diablo kinase inhibition peptidomimetics nanoparticles |
| title | Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatments |
| title_full | Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatments |
| title_fullStr | Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatments |
| title_full_unstemmed | Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatments |
| title_short | Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatments |
| title_sort | bio mimetic strategies to re activate apoptotic cell death for cancer treatments |
| topic | apoptosis bh3-mimetics smac/diablo kinase inhibition peptidomimetics nanoparticles |
| url | https://www.explorationpub.com/uploads/Article/A100874/100874.pdf |
| work_keys_str_mv | AT andreavenerando biomimeticstrategiestoreactivateapoptoticcelldeathforcancertreatments AT deniselovison biomimeticstrategiestoreactivateapoptoticcelldeathforcancertreatments AT rossellademarco biomimeticstrategiestoreactivateapoptoticcelldeathforcancertreatments |