Disseminated Pyrazinamide-Resistant Mycobacterium Bovis in an AIDS Patient: The Role of Molecular Diagnosis and Optimized Therapy
Yuan Fang,* Fuchun Wang,* Jiahao Ji,* Han Jia, Meixin Ren, Luyao Zheng, Lin Jia, Caiping Guo, Wen Wang, Taiyi Jiang, Tong Zhang Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, People’s Republic of China&...
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Dove Medical Press
2025-05-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/disseminated-pyrazinamide-resistant-mycobacterium-bovis-in-an-aids-pat-peer-reviewed-fulltext-article-IDR |
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| author | Fang Y Wang F Ji J Jia H Ren M Zheng L Jia L Guo C Wang W Jiang T Zhang T |
| author_facet | Fang Y Wang F Ji J Jia H Ren M Zheng L Jia L Guo C Wang W Jiang T Zhang T |
| author_sort | Fang Y |
| collection | DOAJ |
| description | Yuan Fang,* Fuchun Wang,* Jiahao Ji,* Han Jia, Meixin Ren, Luyao Zheng, Lin Jia, Caiping Guo, Wen Wang, Taiyi Jiang, Tong Zhang Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tong Zhang, Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai, Fengtai District, Beijing, 100069, People’s Republic of China, Email zt_doc@ccmu.edu.cn Taiyi Jiang, Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai, Fengtai District, Beijing, 100069, People’s Republic of China, Email jtyii2004@126.comAbstract: Disseminated Mycobacterium bovis (M. bovis) infection is a rare but serious complication in immunocompromised individuals, particularly in those with advanced HIV/AIDS. Diagnosis is often delayed owing to overlapping clinical features with those of other mycobacterial infections. We report a case of disseminated M. bovis infection in a severely immunocompromised patient with AIDS. Rapid identification was achieved using molecular diagnostic techniques, specifically fluorescent PCR melting curve analysis, which enabled timely adjustments to antimicrobial therapy. The patient showed significant clinical improvement and resolution of symptoms. This case underscores the importance of early molecular diagnostics and tailored therapeutic strategies for managing opportunistic infections, such as M. bovis, in patients with HIV/AIDS. These findings highlight the need for broader implementation of advanced diagnostic tools to improve outcomes and mitigate the risks of treatment failure and drug resistance in vulnerable populations.Keywords: M. bovis, PZA-resistant, AIDS, opportunistic infection, co-infection |
| format | Article |
| id | doaj-art-8d044af2add243bdbf59a94c1d1a6d89 |
| institution | Kabale University |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj-art-8d044af2add243bdbf59a94c1d1a6d892025-08-20T03:27:48ZengDove Medical PressInfection and Drug Resistance1178-69732025-05-01Volume 18Issue 125992604103066Disseminated Pyrazinamide-Resistant Mycobacterium Bovis in an AIDS Patient: The Role of Molecular Diagnosis and Optimized TherapyFang Y0Wang F1Ji J2Jia HRen MZheng LJia LGuo C3Wang W4Jiang TZhang T5Center for Infectious DiseasesCenter for Infectious DiseasesCenter for Infectious DiseasesCenter for Infectious DiseasesCenter for Infectious DiseasesCenter for Infectious DiseasesYuan Fang,* Fuchun Wang,* Jiahao Ji,* Han Jia, Meixin Ren, Luyao Zheng, Lin Jia, Caiping Guo, Wen Wang, Taiyi Jiang, Tong Zhang Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tong Zhang, Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai, Fengtai District, Beijing, 100069, People’s Republic of China, Email zt_doc@ccmu.edu.cn Taiyi Jiang, Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai, Fengtai District, Beijing, 100069, People’s Republic of China, Email jtyii2004@126.comAbstract: Disseminated Mycobacterium bovis (M. bovis) infection is a rare but serious complication in immunocompromised individuals, particularly in those with advanced HIV/AIDS. Diagnosis is often delayed owing to overlapping clinical features with those of other mycobacterial infections. We report a case of disseminated M. bovis infection in a severely immunocompromised patient with AIDS. Rapid identification was achieved using molecular diagnostic techniques, specifically fluorescent PCR melting curve analysis, which enabled timely adjustments to antimicrobial therapy. The patient showed significant clinical improvement and resolution of symptoms. This case underscores the importance of early molecular diagnostics and tailored therapeutic strategies for managing opportunistic infections, such as M. bovis, in patients with HIV/AIDS. These findings highlight the need for broader implementation of advanced diagnostic tools to improve outcomes and mitigate the risks of treatment failure and drug resistance in vulnerable populations.Keywords: M. bovis, PZA-resistant, AIDS, opportunistic infection, co-infectionhttps://www.dovepress.com/disseminated-pyrazinamide-resistant-mycobacterium-bovis-in-an-aids-pat-peer-reviewed-fulltext-article-IDRM. bovisPZA-ResistantAIDSOpportunistic InfectionCo-infection. |
| spellingShingle | Fang Y Wang F Ji J Jia H Ren M Zheng L Jia L Guo C Wang W Jiang T Zhang T Disseminated Pyrazinamide-Resistant Mycobacterium Bovis in an AIDS Patient: The Role of Molecular Diagnosis and Optimized Therapy Infection and Drug Resistance M. bovis PZA-Resistant AIDS Opportunistic Infection Co-infection. |
| title | Disseminated Pyrazinamide-Resistant Mycobacterium Bovis in an AIDS Patient: The Role of Molecular Diagnosis and Optimized Therapy |
| title_full | Disseminated Pyrazinamide-Resistant Mycobacterium Bovis in an AIDS Patient: The Role of Molecular Diagnosis and Optimized Therapy |
| title_fullStr | Disseminated Pyrazinamide-Resistant Mycobacterium Bovis in an AIDS Patient: The Role of Molecular Diagnosis and Optimized Therapy |
| title_full_unstemmed | Disseminated Pyrazinamide-Resistant Mycobacterium Bovis in an AIDS Patient: The Role of Molecular Diagnosis and Optimized Therapy |
| title_short | Disseminated Pyrazinamide-Resistant Mycobacterium Bovis in an AIDS Patient: The Role of Molecular Diagnosis and Optimized Therapy |
| title_sort | disseminated pyrazinamide resistant mycobacterium bovis in an aids patient the role of molecular diagnosis and optimized therapy |
| topic | M. bovis PZA-Resistant AIDS Opportunistic Infection Co-infection. |
| url | https://www.dovepress.com/disseminated-pyrazinamide-resistant-mycobacterium-bovis-in-an-aids-pat-peer-reviewed-fulltext-article-IDR |
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