Prevalence, impact on quality of life, and predictive factors of coexistence of overactive bladder and underactive bladder in men
Abstract Co-existent overactive-underactive bladder (COUB) is an area of highly unmet medical need, and epidemiological information is lacking, especially in men. Therefore, to illuminate the epidemiological characteristics of COUB in men, 3112 adult Japanese men responding to a nationwide internet...
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Nature Portfolio
2025-07-01
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| author | Noritoshi Sekido Kenji Omae Nobuhiro Haga Yasue Kubota Motoaki Saito Ryuji Sakakibara Mikako Yoshida Takahiko Mitsui Naoya Masumori Satoru Takahashi |
| author_facet | Noritoshi Sekido Kenji Omae Nobuhiro Haga Yasue Kubota Motoaki Saito Ryuji Sakakibara Mikako Yoshida Takahiko Mitsui Naoya Masumori Satoru Takahashi |
| author_sort | Noritoshi Sekido |
| collection | DOAJ |
| description | Abstract Co-existent overactive-underactive bladder (COUB) is an area of highly unmet medical need, and epidemiological information is lacking, especially in men. Therefore, to illuminate the epidemiological characteristics of COUB in men, 3112 adult Japanese men responding to a nationwide internet survey on lower urinary tract symptoms (LUTS) were divided into COUB, overactive bladder (OAB) alone, underactive bladder (UAB) alone, and non-OAB/UAB groups based on the OAB symptom score and the International Continence Society-Working Group definition of UAB. We assessed each group’s prevalence and health-related quality of life (HRQOL) and explored predictors of COUB as well as OAB and UAB using multinomial logistic regression analysis. The prevalences of COUB, OAB alone, and UAB alone were 4.3%, 9.6%, and 5.0%, respectively, and increased significantly with age. The proportions of COUB in OAB and UAB overall were 31.1% and 46.6%, respectively, but showed no significant increase with age. The proportion of participants experiencing an impact on their HRQOL was highest in the COUB group. A multinomial logistic regression analysis revealed that COUB and OAB alone shared predictive factors. The presence of COUB has a considerable impact on HRQOL and should be kept in mind when managing LUTS in men. |
| format | Article |
| id | doaj-art-8d03f5e91cea46b69330596214c436bc |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-8d03f5e91cea46b69330596214c436bc2025-08-20T03:45:35ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-06299-wPrevalence, impact on quality of life, and predictive factors of coexistence of overactive bladder and underactive bladder in menNoritoshi Sekido0Kenji Omae1Nobuhiro Haga2Yasue Kubota3Motoaki Saito4Ryuji Sakakibara5Mikako Yoshida6Takahiko Mitsui7Naoya Masumori8Satoru Takahashi9Epidemiological Survey Executive Committee, The Japanese Continence SocietyEpidemiological Survey Executive Committee, The Japanese Continence SocietyEpidemiological Survey Executive Committee, The Japanese Continence SocietyEpidemiological Survey Executive Committee, The Japanese Continence SocietyEpidemiological Survey Executive Committee, The Japanese Continence SocietyEpidemiological Survey Executive Committee, The Japanese Continence SocietyEpidemiological Survey Executive Committee, The Japanese Continence SocietyEpidemiological Survey Executive Committee, The Japanese Continence SocietyEpidemiological Survey Executive Committee, The Japanese Continence SocietyEpidemiological Survey Executive Committee, The Japanese Continence SocietyAbstract Co-existent overactive-underactive bladder (COUB) is an area of highly unmet medical need, and epidemiological information is lacking, especially in men. Therefore, to illuminate the epidemiological characteristics of COUB in men, 3112 adult Japanese men responding to a nationwide internet survey on lower urinary tract symptoms (LUTS) were divided into COUB, overactive bladder (OAB) alone, underactive bladder (UAB) alone, and non-OAB/UAB groups based on the OAB symptom score and the International Continence Society-Working Group definition of UAB. We assessed each group’s prevalence and health-related quality of life (HRQOL) and explored predictors of COUB as well as OAB and UAB using multinomial logistic regression analysis. The prevalences of COUB, OAB alone, and UAB alone were 4.3%, 9.6%, and 5.0%, respectively, and increased significantly with age. The proportions of COUB in OAB and UAB overall were 31.1% and 46.6%, respectively, but showed no significant increase with age. The proportion of participants experiencing an impact on their HRQOL was highest in the COUB group. A multinomial logistic regression analysis revealed that COUB and OAB alone shared predictive factors. The presence of COUB has a considerable impact on HRQOL and should be kept in mind when managing LUTS in men.https://doi.org/10.1038/s41598-025-06299-wCo-existent overactive-underactive bladderEpidemiologyHealth-related quality of lifeOveractive bladderPrevalenceUnderactive bladder |
| spellingShingle | Noritoshi Sekido Kenji Omae Nobuhiro Haga Yasue Kubota Motoaki Saito Ryuji Sakakibara Mikako Yoshida Takahiko Mitsui Naoya Masumori Satoru Takahashi Prevalence, impact on quality of life, and predictive factors of coexistence of overactive bladder and underactive bladder in men Scientific Reports Co-existent overactive-underactive bladder Epidemiology Health-related quality of life Overactive bladder Prevalence Underactive bladder |
| title | Prevalence, impact on quality of life, and predictive factors of coexistence of overactive bladder and underactive bladder in men |
| title_full | Prevalence, impact on quality of life, and predictive factors of coexistence of overactive bladder and underactive bladder in men |
| title_fullStr | Prevalence, impact on quality of life, and predictive factors of coexistence of overactive bladder and underactive bladder in men |
| title_full_unstemmed | Prevalence, impact on quality of life, and predictive factors of coexistence of overactive bladder and underactive bladder in men |
| title_short | Prevalence, impact on quality of life, and predictive factors of coexistence of overactive bladder and underactive bladder in men |
| title_sort | prevalence impact on quality of life and predictive factors of coexistence of overactive bladder and underactive bladder in men |
| topic | Co-existent overactive-underactive bladder Epidemiology Health-related quality of life Overactive bladder Prevalence Underactive bladder |
| url | https://doi.org/10.1038/s41598-025-06299-w |
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