Dual role of p21 in regulating apoptosis and mitotic integrity in response to doxorubicin in colon cancer cells

Dual role of p21 in regulating apoptosis and mitotic integrity in response to doxorubicin in colon cancer cells

Abstract This study explores the multifaceted role of p21 in mediating cellular responses to DNA-damaging agents, with a focus on doxorubicin treatment in HCT116 colon carcinoma cells. We investigated how different doses of doxorubicin affect cells with varied p21 and p53 statuses, revealing distinc...

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Bibliographic Details
Main Authors: Heeyeon Kim, Haein Kim, Eunjung Jang, Young-Woo Eom, Gyesoon Yoon, Kyeong Sook Choi, Eunhee Kim
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02416-w
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