Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions
Isotretinoin (13-cis-retinoic acid), a synthetic vitamin A derivative, is used to treat a wide variety of dermatologic conditions including severe acne. Isotretinoin can trigger premature ventricular contractions (PVCs). We describe a 17-year-old boy who presented with PVCs on electrocardiogr...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2009-08-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2323 |
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| _version_ | 1850023913221783552 |
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| author | Esra Kiliç Murat Sahin Sedef Sahin Sema Ozer |
| author_facet | Esra Kiliç Murat Sahin Sedef Sahin Sema Ozer |
| author_sort | Esra Kiliç |
| collection | DOAJ |
| description |
Isotretinoin (13-cis-retinoic acid), a synthetic vitamin A derivative, is used to treat a wide variety of dermatologic conditions including severe acne. Isotretinoin can trigger premature ventricular contractions (PVCs). We describe a 17-year-old boy who presented with PVCs on electrocardiogram during isotretinoin (Roaccutane, Roche) treatment for nodular facial acne. Presence of documented PVCs -on electrocardiogram and Holter monitoring- and the disappearance of these PVCs after cessation of the treatment strongly suggest isotretinoin-related PVCs in our case. The impact of isotretinoin on ventricular rhythm can not be ruled out in our case as we have revealed the presence of the temporal association of isotretinoin and documented PVCs. Thus, clinicians should be aware of possible arrhythmogenic effect(s) of isotretinoin.
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| format | Article |
| id | doaj-art-8cfbeb43232e486199f5de8345f5c163 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2009-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-8cfbeb43232e486199f5de8345f5c1632025-08-20T03:01:15ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212009-08-01514Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractionsEsra Kiliç0Murat SahinSedef SahinSema OzerPediatric Cardiology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. Isotretinoin (13-cis-retinoic acid), a synthetic vitamin A derivative, is used to treat a wide variety of dermatologic conditions including severe acne. Isotretinoin can trigger premature ventricular contractions (PVCs). We describe a 17-year-old boy who presented with PVCs on electrocardiogram during isotretinoin (Roaccutane, Roche) treatment for nodular facial acne. Presence of documented PVCs -on electrocardiogram and Holter monitoring- and the disappearance of these PVCs after cessation of the treatment strongly suggest isotretinoin-related PVCs in our case. The impact of isotretinoin on ventricular rhythm can not be ruled out in our case as we have revealed the presence of the temporal association of isotretinoin and documented PVCs. Thus, clinicians should be aware of possible arrhythmogenic effect(s) of isotretinoin. https://turkjpediatr.org/article/view/2323 |
| spellingShingle | Esra Kiliç Murat Sahin Sedef Sahin Sema Ozer Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions The Turkish Journal of Pediatrics |
| title | Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions |
| title_full | Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions |
| title_fullStr | Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions |
| title_full_unstemmed | Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions |
| title_short | Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions |
| title_sort | isotretinoin 13 cis retinoic acid associated premature ventricular contractions |
| url | https://turkjpediatr.org/article/view/2323 |
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