Review of MicroRNA Deregulation in Oral Cancer. Part I
Objectives: Oral cancer is the sixth most common malignancy worldwide. Cancer development and progression requires inactivation of tumour suppressor genes and activation of proto-oncogenes. Expression of these genes is in part dependant on RNA and microRNA based mechanisms. MicroRNAs are essential r...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Lithuanian University of Health Sciences, Faculty of Odontology
2011-04-01
|
| Series: | eJournal of Oral Maxillofacial Research |
| Subjects: | |
| Online Access: | http://www.ejomr.org/JOMR/archives/2011/2/e1/v2n2e1ht.htm |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850053200239919104 |
|---|---|
| author | Antonia Kolokythas Michael Miloro Xiaofeng Zhou |
| author_facet | Antonia Kolokythas Michael Miloro Xiaofeng Zhou |
| author_sort | Antonia Kolokythas |
| collection | DOAJ |
| description | Objectives: Oral cancer is the sixth most common malignancy worldwide. Cancer development and progression requires inactivation of tumour suppressor genes and activation of proto-oncogenes. Expression of these genes is in part dependant on RNA and microRNA based mechanisms. MicroRNAs are essential regulators of diverse cellular processes including proliferation, differentiation, apoptosis, survival, motility, invasion and morphogenesis. Several microRNAs have been found to be aberrantly expressed in various cancers including oral cancer.Material and Methods: A comprehensive review of the available literature from 2000 to 2011 relevant to microRNA deregulation in oral cancer was undertaken using PubMed, Medline, Scholar Google and Scopus. Keywords for the search were: microRNA and oral cancer, microRNA and squamous cell carcinoma, microRNA deregulation. Only full length articles in the English language were included. Strengths and limitations of each study are presented in this review.Results: Several studies were identified that investigated microRNA alternations in the head and neck/oral cavity cancers. Significant progress has been made in identification of microRNA deregulation in these cancers. It has been evident that several microRNAs were found to be deregulated specifically in oral cavity cancers. Among these, several microRNAs have been functionally validated and their potential target genes have been identified.Conclusions: These findings on microRNA deregulation in cancer further enhance our understanding of the disease progression, response to treatment and may assist with future development of targeted therapy. |
| format | Article |
| id | doaj-art-8cfae4198217490584666dce093eaad1 |
| institution | DOAJ |
| issn | 2029-283X |
| language | English |
| publishDate | 2011-04-01 |
| publisher | Lithuanian University of Health Sciences, Faculty of Odontology |
| record_format | Article |
| series | eJournal of Oral Maxillofacial Research |
| spelling | doaj-art-8cfae4198217490584666dce093eaad12025-08-20T02:52:35ZengLithuanian University of Health Sciences, Faculty of OdontologyeJournal of Oral Maxillofacial Research2029-283X2011-04-0122e1Review of MicroRNA Deregulation in Oral Cancer. Part IAntonia KolokythasMichael MiloroXiaofeng ZhouObjectives: Oral cancer is the sixth most common malignancy worldwide. Cancer development and progression requires inactivation of tumour suppressor genes and activation of proto-oncogenes. Expression of these genes is in part dependant on RNA and microRNA based mechanisms. MicroRNAs are essential regulators of diverse cellular processes including proliferation, differentiation, apoptosis, survival, motility, invasion and morphogenesis. Several microRNAs have been found to be aberrantly expressed in various cancers including oral cancer.Material and Methods: A comprehensive review of the available literature from 2000 to 2011 relevant to microRNA deregulation in oral cancer was undertaken using PubMed, Medline, Scholar Google and Scopus. Keywords for the search were: microRNA and oral cancer, microRNA and squamous cell carcinoma, microRNA deregulation. Only full length articles in the English language were included. Strengths and limitations of each study are presented in this review.Results: Several studies were identified that investigated microRNA alternations in the head and neck/oral cavity cancers. Significant progress has been made in identification of microRNA deregulation in these cancers. It has been evident that several microRNAs were found to be deregulated specifically in oral cavity cancers. Among these, several microRNAs have been functionally validated and their potential target genes have been identified.Conclusions: These findings on microRNA deregulation in cancer further enhance our understanding of the disease progression, response to treatment and may assist with future development of targeted therapy.http://www.ejomr.org/JOMR/archives/2011/2/e1/v2n2e1ht.htmoral canceroral neoplasmshead and neck cancerheadneck neoplasmsmicroRNAreview |
| spellingShingle | Antonia Kolokythas Michael Miloro Xiaofeng Zhou Review of MicroRNA Deregulation in Oral Cancer. Part I eJournal of Oral Maxillofacial Research oral cancer oral neoplasms head and neck cancer head neck neoplasms microRNA review |
| title | Review of MicroRNA Deregulation in Oral Cancer. Part I |
| title_full | Review of MicroRNA Deregulation in Oral Cancer. Part I |
| title_fullStr | Review of MicroRNA Deregulation in Oral Cancer. Part I |
| title_full_unstemmed | Review of MicroRNA Deregulation in Oral Cancer. Part I |
| title_short | Review of MicroRNA Deregulation in Oral Cancer. Part I |
| title_sort | review of microrna deregulation in oral cancer part i |
| topic | oral cancer oral neoplasms head and neck cancer head neck neoplasms microRNA review |
| url | http://www.ejomr.org/JOMR/archives/2011/2/e1/v2n2e1ht.htm |
| work_keys_str_mv | AT antoniakolokythas reviewofmicrornaderegulationinoralcancerparti AT michaelmiloro reviewofmicrornaderegulationinoralcancerparti AT xiaofengzhou reviewofmicrornaderegulationinoralcancerparti |