Cigarette smoke alters circRNA expression in human T-cells [version 2; peer review: 1 approved, 2 approved with reservations]
Circular RNAs (circRNAs), once thought to be a result of splicing errors, have been found to be involved in various molecular processes and the pathology of various diseases, including cancer and neurodegenerative diseases. Additionally, circRNA expression was found to be altered by lifestyle habits...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2024-06-01
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| Online Access: | https://f1000research.com/articles/12-566/v2 |
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| author | Kenneth W. Witwer Ashley E. Russell So Jin Hong Zhaohao Liao |
| author_facet | Kenneth W. Witwer Ashley E. Russell So Jin Hong Zhaohao Liao |
| author_sort | Kenneth W. Witwer |
| collection | DOAJ |
| description | Circular RNAs (circRNAs), once thought to be a result of splicing errors, have been found to be involved in various molecular processes and the pathology of various diseases, including cancer and neurodegenerative diseases. Additionally, circRNA expression was found to be altered by lifestyle habits, such as smoking cigarettes. Past studies have revealed that the rate of smoking remains high in people living with human immunodeficiency virus (HIV). In this study, we isolated total RNA from uninfected T-cells that have been exposed to cigarette smoke and compared the expression levels of circRNAs to those of T-cells that were not exposed to cigarette smoke. We identified certain circRNAs that were upregulated or downregulated in T-cells when exposed to cigarette smoke. These data indicate that the study of circRNAs is warranted within the context of HIV. |
| format | Article |
| id | doaj-art-8cf7151e06b74f408f5af64eff6788f8 |
| institution | OA Journals |
| issn | 2046-1402 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj-art-8cf7151e06b74f408f5af64eff6788f82025-08-20T02:13:48ZengF1000 Research LtdF1000Research2046-14022024-06-011210.12688/f1000research.130430.2167219Cigarette smoke alters circRNA expression in human T-cells [version 2; peer review: 1 approved, 2 approved with reservations]Kenneth W. Witwer0Ashley E. Russell1So Jin Hong2https://orcid.org/0000-0002-4072-3735Zhaohao Liao3Department of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USADepartment of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USADepartment of Molecular and Cellular Biology, Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, Maryland, USADepartment of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USACircular RNAs (circRNAs), once thought to be a result of splicing errors, have been found to be involved in various molecular processes and the pathology of various diseases, including cancer and neurodegenerative diseases. Additionally, circRNA expression was found to be altered by lifestyle habits, such as smoking cigarettes. Past studies have revealed that the rate of smoking remains high in people living with human immunodeficiency virus (HIV). In this study, we isolated total RNA from uninfected T-cells that have been exposed to cigarette smoke and compared the expression levels of circRNAs to those of T-cells that were not exposed to cigarette smoke. We identified certain circRNAs that were upregulated or downregulated in T-cells when exposed to cigarette smoke. These data indicate that the study of circRNAs is warranted within the context of HIV.https://f1000research.com/articles/12-566/v2Cigarette smoke T-cells circRNA HIVeng |
| spellingShingle | Kenneth W. Witwer Ashley E. Russell So Jin Hong Zhaohao Liao Cigarette smoke alters circRNA expression in human T-cells [version 2; peer review: 1 approved, 2 approved with reservations] F1000Research Cigarette smoke T-cells circRNA HIV eng |
| title | Cigarette smoke alters circRNA expression in human T-cells [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full | Cigarette smoke alters circRNA expression in human T-cells [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_fullStr | Cigarette smoke alters circRNA expression in human T-cells [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full_unstemmed | Cigarette smoke alters circRNA expression in human T-cells [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_short | Cigarette smoke alters circRNA expression in human T-cells [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_sort | cigarette smoke alters circrna expression in human t cells version 2 peer review 1 approved 2 approved with reservations |
| topic | Cigarette smoke T-cells circRNA HIV eng |
| url | https://f1000research.com/articles/12-566/v2 |
| work_keys_str_mv | AT kennethwwitwer cigarettesmokealterscircrnaexpressioninhumantcellsversion2peerreview1approved2approvedwithreservations AT ashleyerussell cigarettesmokealterscircrnaexpressioninhumantcellsversion2peerreview1approved2approvedwithreservations AT sojinhong cigarettesmokealterscircrnaexpressioninhumantcellsversion2peerreview1approved2approvedwithreservations AT zhaohaoliao cigarettesmokealterscircrnaexpressioninhumantcellsversion2peerreview1approved2approvedwithreservations |