Infectious diseases during pregnancy in Brazil: seroprevalence and risk factors
Introduction: Vertically transmitted infections are caused by a diversity of pathogenic microorganisms. Pregnant women are routinely screened to evaluate the risks and reduce the burden of disorders in their unborn children. We assessed the prevalence and possible risk factors for Cytomegalovirus (...
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The Journal of Infection in Developing Countries
2018-08-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/9492 |
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| author | Galileu Barbosa Costa Mário Cézar de Oliveira Sandra Rocha Gadelha George Rego Albuquerque Marcel Teixeira Monica Regina da Silva Raiol Sandra Mara Bispo Sousa Lauro Juliano Marin |
| author_facet | Galileu Barbosa Costa Mário Cézar de Oliveira Sandra Rocha Gadelha George Rego Albuquerque Marcel Teixeira Monica Regina da Silva Raiol Sandra Mara Bispo Sousa Lauro Juliano Marin |
| author_sort | Galileu Barbosa Costa |
| collection | DOAJ |
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Introduction: Vertically transmitted infections are caused by a diversity of pathogenic microorganisms. Pregnant women are routinely screened to evaluate the risks and reduce the burden of disorders in their unborn children. We assessed the prevalence and possible risk factors for Cytomegalovirus (CMV), Rubella, Human T lymphotropic virus (HTLV), and Toxoplasma gondii in pregnant women from the South region of Bahia State, Brazil.
Methodology: Serum samples were obtained from 726 pregnant women aged between 13 and 44 years, with a median age of 24 years. ELISA assays were used to detect CMV, Rubella, HTLV and T. gondii IgG and IgM antibodies.
Results: The prevalence rates of IgG antibodies found were 95.2% for CMV, 97.0% for Rubella, and 72.3% for T. gondii. Furthermore, the prevalence of HTLV-1/2 was 1.2%. IgM antibodies were reactive only for CMV (0.8%) and T. gondii (3.7%). Variables independently associated with the detection of anti-T. gondii IgG antibodies were white self-reported race/ethnicity (Odds Ratio [OR] 2.26, 95% CI 1.26–4.06, P = 0.006), wage income (OR 0.55, 95% CI 0.35–0.88, P = 0.013), and history of previous pregnancy (OR 1.60, 95% CI 1.02–2.50, P = 0.038).
Conclusions: This study highlights the importance of monitoring for infectious diseases during pregnancy and initiation of early interventions to reduce the burden of fetal losses and other important infant sequelae attributable to congenital infections.
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| format | Article |
| id | doaj-art-8cf031f1926e4f85b168f4a19e446c37 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-8cf031f1926e4f85b168f4a19e446c372025-08-20T03:52:38ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802018-08-01120810.3855/jidc.9492Infectious diseases during pregnancy in Brazil: seroprevalence and risk factorsGalileu Barbosa Costa0Mário Cézar de Oliveira1Sandra Rocha Gadelha2George Rego Albuquerque3Marcel Teixeira4Monica Regina da Silva Raiol5Sandra Mara Bispo Sousa6Lauro Juliano Marin7Universidade Estadual de Santa Cruz, Ilhéus, BrazilUniversidade Estadual de Santa Cruz, Ilhéus, BrazilUniversidade Estadual de Santa Cruz, Ilhéus, BrazilUniversidade Estadual de Santa Cruz, Ilhéus, BrazilEmbrapa Caprinos e Ovinos, Brasília, BrazilUniversidade Estadual de Santa Cruz, Ilhéus, BrazilUniversidade Estadual de Santa Cruz, Ilhéus, BrazilUniversidade Estadual de Santa Cruz, Ilhéus, Brazil Introduction: Vertically transmitted infections are caused by a diversity of pathogenic microorganisms. Pregnant women are routinely screened to evaluate the risks and reduce the burden of disorders in their unborn children. We assessed the prevalence and possible risk factors for Cytomegalovirus (CMV), Rubella, Human T lymphotropic virus (HTLV), and Toxoplasma gondii in pregnant women from the South region of Bahia State, Brazil. Methodology: Serum samples were obtained from 726 pregnant women aged between 13 and 44 years, with a median age of 24 years. ELISA assays were used to detect CMV, Rubella, HTLV and T. gondii IgG and IgM antibodies. Results: The prevalence rates of IgG antibodies found were 95.2% for CMV, 97.0% for Rubella, and 72.3% for T. gondii. Furthermore, the prevalence of HTLV-1/2 was 1.2%. IgM antibodies were reactive only for CMV (0.8%) and T. gondii (3.7%). Variables independently associated with the detection of anti-T. gondii IgG antibodies were white self-reported race/ethnicity (Odds Ratio [OR] 2.26, 95% CI 1.26–4.06, P = 0.006), wage income (OR 0.55, 95% CI 0.35–0.88, P = 0.013), and history of previous pregnancy (OR 1.60, 95% CI 1.02–2.50, P = 0.038). Conclusions: This study highlights the importance of monitoring for infectious diseases during pregnancy and initiation of early interventions to reduce the burden of fetal losses and other important infant sequelae attributable to congenital infections. https://jidc.org/index.php/journal/article/view/9492CytomegalovirusRubellaHuman T lymphotropic virusToxoplasma gondiipregnant womenpublic health |
| spellingShingle | Galileu Barbosa Costa Mário Cézar de Oliveira Sandra Rocha Gadelha George Rego Albuquerque Marcel Teixeira Monica Regina da Silva Raiol Sandra Mara Bispo Sousa Lauro Juliano Marin Infectious diseases during pregnancy in Brazil: seroprevalence and risk factors Journal of Infection in Developing Countries Cytomegalovirus Rubella Human T lymphotropic virus Toxoplasma gondii pregnant women public health |
| title | Infectious diseases during pregnancy in Brazil: seroprevalence and risk factors |
| title_full | Infectious diseases during pregnancy in Brazil: seroprevalence and risk factors |
| title_fullStr | Infectious diseases during pregnancy in Brazil: seroprevalence and risk factors |
| title_full_unstemmed | Infectious diseases during pregnancy in Brazil: seroprevalence and risk factors |
| title_short | Infectious diseases during pregnancy in Brazil: seroprevalence and risk factors |
| title_sort | infectious diseases during pregnancy in brazil seroprevalence and risk factors |
| topic | Cytomegalovirus Rubella Human T lymphotropic virus Toxoplasma gondii pregnant women public health |
| url | https://jidc.org/index.php/journal/article/view/9492 |
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