CYP1A2 genotype and acute effects of caffeine intake on growth hormone and testosterone response to resistance exercise
Background: Caffeine is widely recognized as a potent ergogenic aid commonly used to enhance exercise performance and recovery. However, individual responses to caffeine can vary significantly, a variability that might be explained by genetic differences.Aim: This study aimed to investigate the infl...
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University of Tehran
2024-07-01
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| Series: | Sport Sciences and Health Research |
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| Online Access: | https://sshr.ut.ac.ir/article_99685_721f7de4122b34337393132cbfff730e.pdf |
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| author | Mohammad Rahman Rahimi Hassan Faraji Maryam Khodamoradi |
| author_facet | Mohammad Rahman Rahimi Hassan Faraji Maryam Khodamoradi |
| author_sort | Mohammad Rahman Rahimi |
| collection | DOAJ |
| description | Background: Caffeine is widely recognized as a potent ergogenic aid commonly used to enhance exercise performance and recovery. However, individual responses to caffeine can vary significantly, a variability that might be explained by genetic differences.Aim: This study aimed to investigate the influence of the CYP1A2 rs762551 SNP on the effects of caffeine (CAF) consumption on growth hormone (GH) and testosterone (TS) levels response to resistance exercise (RE) in male athletes.Materials and Methods: Thirty resistance-trained men (mean age 21.72±4.06 years, weight 77.31±14.07 kg, height 179.31±5.08 cm) participated in a randomized, double-blind, placebo-controlled, crossover study. They consumed either CAF (6 mg/kg) or placebo (PL; 6 mg/kg maltodextrin) one hour before performing a RE protocol including three sets with 85% of 1RM and two-minute rest. CYP1A2 genotyping categorized participants as AA homozygous ("fast" metabolizers) or AC heterozygous ("slow" metabolizers). GH and TS levels were measured by ELISA methods.Results: Repeated measures ANOVA showed significant differences in GH levels across time (F=10.94, P=0.000), with significant time-group (F=4.3, P=0.019) and time-genotype-group interactions (F=3.83, P=0.024). One-way ANOVA indicated significant differences in GH levels between CAF and PL conditions in AA individuals, but not in AC/CC genotypes. For testosterone, significant effects of time (F=14.88, P=0.000) and time-group interaction (F=3.197, P=0.045) were observed. Post-RE CAF supplementation significantly increased serum GH and TS levels in AA individuals compared to PL. Both CAF and PL groups showed increased serum hormone concentrations post-exercise.Conclusion: In conclusion, the study demonstrated that caffeine consumption significantly increased serum levels of growth hormone and testosterone in individuals with the AA genotype of the CYP1A2 rs762551 SNP. These findings suggest that genetic variations play a role in the hormonal response to caffeine, which may have implications for exercise performance and recovery strategies. |
| format | Article |
| id | doaj-art-8cef489fd82a451f924d1b2941449346 |
| institution | DOAJ |
| issn | 2981-0205 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Sport Sciences and Health Research |
| spelling | doaj-art-8cef489fd82a451f924d1b29414493462025-08-20T03:10:31ZengUniversity of TehranSport Sciences and Health Research2981-02052024-07-0116227929310.22059/sshr.2024.382033.116399685CYP1A2 genotype and acute effects of caffeine intake on growth hormone and testosterone response to resistance exerciseMohammad Rahman Rahimi0Hassan Faraji1Maryam Khodamoradi2Department of Exercise Physiology, University of Kurdistan, Sanandaj 66177-15175, Iran. ORCID No: https://orcid.org/0000-0002-4302-1472Department of Physical Education and Sports Science, Marivan Branch, Islamic Azad University, Marivan, Iran.Department of Exercise Physiology, University of Kurdistan, 66177-15175 Sanandaj, IranBackground: Caffeine is widely recognized as a potent ergogenic aid commonly used to enhance exercise performance and recovery. However, individual responses to caffeine can vary significantly, a variability that might be explained by genetic differences.Aim: This study aimed to investigate the influence of the CYP1A2 rs762551 SNP on the effects of caffeine (CAF) consumption on growth hormone (GH) and testosterone (TS) levels response to resistance exercise (RE) in male athletes.Materials and Methods: Thirty resistance-trained men (mean age 21.72±4.06 years, weight 77.31±14.07 kg, height 179.31±5.08 cm) participated in a randomized, double-blind, placebo-controlled, crossover study. They consumed either CAF (6 mg/kg) or placebo (PL; 6 mg/kg maltodextrin) one hour before performing a RE protocol including three sets with 85% of 1RM and two-minute rest. CYP1A2 genotyping categorized participants as AA homozygous ("fast" metabolizers) or AC heterozygous ("slow" metabolizers). GH and TS levels were measured by ELISA methods.Results: Repeated measures ANOVA showed significant differences in GH levels across time (F=10.94, P=0.000), with significant time-group (F=4.3, P=0.019) and time-genotype-group interactions (F=3.83, P=0.024). One-way ANOVA indicated significant differences in GH levels between CAF and PL conditions in AA individuals, but not in AC/CC genotypes. For testosterone, significant effects of time (F=14.88, P=0.000) and time-group interaction (F=3.197, P=0.045) were observed. Post-RE CAF supplementation significantly increased serum GH and TS levels in AA individuals compared to PL. Both CAF and PL groups showed increased serum hormone concentrations post-exercise.Conclusion: In conclusion, the study demonstrated that caffeine consumption significantly increased serum levels of growth hormone and testosterone in individuals with the AA genotype of the CYP1A2 rs762551 SNP. These findings suggest that genetic variations play a role in the hormonal response to caffeine, which may have implications for exercise performance and recovery strategies.https://sshr.ut.ac.ir/article_99685_721f7de4122b34337393132cbfff730e.pdfcaffeinecyp1a2 rs762551 snphormonal responseresistance exercise |
| spellingShingle | Mohammad Rahman Rahimi Hassan Faraji Maryam Khodamoradi CYP1A2 genotype and acute effects of caffeine intake on growth hormone and testosterone response to resistance exercise Sport Sciences and Health Research caffeine cyp1a2 rs762551 snp hormonal response resistance exercise |
| title | CYP1A2 genotype and acute effects of caffeine intake on growth hormone and testosterone response to resistance exercise |
| title_full | CYP1A2 genotype and acute effects of caffeine intake on growth hormone and testosterone response to resistance exercise |
| title_fullStr | CYP1A2 genotype and acute effects of caffeine intake on growth hormone and testosterone response to resistance exercise |
| title_full_unstemmed | CYP1A2 genotype and acute effects of caffeine intake on growth hormone and testosterone response to resistance exercise |
| title_short | CYP1A2 genotype and acute effects of caffeine intake on growth hormone and testosterone response to resistance exercise |
| title_sort | cyp1a2 genotype and acute effects of caffeine intake on growth hormone and testosterone response to resistance exercise |
| topic | caffeine cyp1a2 rs762551 snp hormonal response resistance exercise |
| url | https://sshr.ut.ac.ir/article_99685_721f7de4122b34337393132cbfff730e.pdf |
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