Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes
Liver enzymes alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) are markers for type 2 diabetes mellitus (T2DM); alkaline phosphatase is a marker of liver disease. Mexican-American adolescents are disproportionately affected by T2DM, while in Mexico its prevalence is emerging. We a...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/4262536 |
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| author | Ana Cecilia Fernández-Gaxiola Roxana Valdés-Ramos Kimberly Fulda Ana Laura Guadarrama López Beatriz E. Martínez-Carrillo Susan F. Franks Shane Fernando |
| author_facet | Ana Cecilia Fernández-Gaxiola Roxana Valdés-Ramos Kimberly Fulda Ana Laura Guadarrama López Beatriz E. Martínez-Carrillo Susan F. Franks Shane Fernando |
| author_sort | Ana Cecilia Fernández-Gaxiola |
| collection | DOAJ |
| description | Liver enzymes alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) are markers for type 2 diabetes mellitus (T2DM); alkaline phosphatase is a marker of liver disease. Mexican-American adolescents are disproportionately affected by T2DM, while in Mexico its prevalence is emerging. We assessed liver biomarkers and lipid profiles among Mexican and Mexican-American adolescents 10–14 years old with high/low risk of T2DM through a cross-sectional, descriptive study (Texas n=144; Mexico n=149). We included family medical histories, anthropometry, and blood pressure. Obesity was present in one-third of subjects in both sites. ALT (UL) was higher (p<0.001) in high-risk adolescents (23.5 ± 19.5 versus 17.2 ± 13.4 for males, 19.7 ± 11.6 versus 15.1 ± 5.5 for females), in Toluca and in Texas (26.0 ± 14.7 versus 20.0 ± 13.2 for males, 18.2 ± 13.4 versus 14.6 ± 10.1 for females), as well as GGT (UL) (p<0.001) (18.7 ± 11.1 versus 12.4 ± 2.3 for males, 13.6 ± 5.8 versus 11.5 ± 3.9 for Mexican females; 21.0 ± 6.8 versus 15.4 ± 5.5 for males, 14.3 ± 5.0 versus 13.8 ± 5.3 for females in Texas). We found no differences by sex or BMI. Total cholesterol and HDL were higher among Mexican-Americans (p<0.001). In conclusion, multiple risk factors were present in the sample. We found differences by gender and between high and low risk for T2DM adolescents in all liver enzymes in both sites. |
| format | Article |
| id | doaj-art-8ceeb6c1e1cc4fb28cf50314c85b6c37 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-8ceeb6c1e1cc4fb28cf50314c85b6c372025-02-03T01:02:38ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/42625364262536Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 DiabetesAna Cecilia Fernández-Gaxiola0Roxana Valdés-Ramos1Kimberly Fulda2Ana Laura Guadarrama López3Beatriz E. Martínez-Carrillo4Susan F. Franks5Shane Fernando6Facultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan Esq. Jesús Carranza. Col. Moderna de la Cruz, 50180 Toluca, MEX, MexicoFacultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan Esq. Jesús Carranza. Col. Moderna de la Cruz, 50180 Toluca, MEX, MexicoDepartment of Family Medicine, Texas Prevention Institute, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USAFacultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan Esq. Jesús Carranza. Col. Moderna de la Cruz, 50180 Toluca, MEX, MexicoFacultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan Esq. Jesús Carranza. Col. Moderna de la Cruz, 50180 Toluca, MEX, MexicoDepartment of Family Medicine, Texas Prevention Institute, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USADepartment of Pediatrics, Texas Prevention Institute, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USALiver enzymes alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) are markers for type 2 diabetes mellitus (T2DM); alkaline phosphatase is a marker of liver disease. Mexican-American adolescents are disproportionately affected by T2DM, while in Mexico its prevalence is emerging. We assessed liver biomarkers and lipid profiles among Mexican and Mexican-American adolescents 10–14 years old with high/low risk of T2DM through a cross-sectional, descriptive study (Texas n=144; Mexico n=149). We included family medical histories, anthropometry, and blood pressure. Obesity was present in one-third of subjects in both sites. ALT (UL) was higher (p<0.001) in high-risk adolescents (23.5 ± 19.5 versus 17.2 ± 13.4 for males, 19.7 ± 11.6 versus 15.1 ± 5.5 for females), in Toluca and in Texas (26.0 ± 14.7 versus 20.0 ± 13.2 for males, 18.2 ± 13.4 versus 14.6 ± 10.1 for females), as well as GGT (UL) (p<0.001) (18.7 ± 11.1 versus 12.4 ± 2.3 for males, 13.6 ± 5.8 versus 11.5 ± 3.9 for Mexican females; 21.0 ± 6.8 versus 15.4 ± 5.5 for males, 14.3 ± 5.0 versus 13.8 ± 5.3 for females in Texas). We found no differences by sex or BMI. Total cholesterol and HDL were higher among Mexican-Americans (p<0.001). In conclusion, multiple risk factors were present in the sample. We found differences by gender and between high and low risk for T2DM adolescents in all liver enzymes in both sites.http://dx.doi.org/10.1155/2017/4262536 |
| spellingShingle | Ana Cecilia Fernández-Gaxiola Roxana Valdés-Ramos Kimberly Fulda Ana Laura Guadarrama López Beatriz E. Martínez-Carrillo Susan F. Franks Shane Fernando Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes Journal of Diabetes Research |
| title | Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes |
| title_full | Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes |
| title_fullStr | Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes |
| title_full_unstemmed | Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes |
| title_short | Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes |
| title_sort | liver biomarkers and lipid profiles in mexican and mexican american 10 to 14 year old adolescents at risk for type 2 diabetes |
| url | http://dx.doi.org/10.1155/2017/4262536 |
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