Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial

Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial

Background Overweight and obesity affect over 60% of the United Kingdom population and constitute a major risk factor for the development of comorbidities. Preventing weight gain in periods of life where there is an elevated risk of adipose tissue expansion could be beneficial in preventing associat...

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Main Authors: Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, Leah Holroyd, Christina Prechtl, Tom Preston, Mike J Lean, Waljit Dhillo, A Toby Prevost, and Douglas Morrison
Format: Article
Language:English
Published: NIHR Journals Library 2025-07-01
Series:Efficacy and Mechanism Evaluation
Subjects:
obesity
prevention
short-chain fatty acids
dietary fibre
gut microbiota
young adults
propionate
inulin
randomised controlled trial
Online Access:https://doi.org/10.3310/GKWP5267
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