Safety and efficacy of extravascular renal denervation using HyperQure™ renal denervation system in short-term swine model of hypertension
This study investigated the safety and efficacy of the HyperQure™ extravascular renal denervation (RDN) system in a swine model of mild hypertension. Ten female pigs were fed a 3% salt diet to induce hypertension and underwent either extravascular RDN using the HyperQure™ RDN system (n = 7) or a sha...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10641963.2025.2474520 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849325972396965888 |
|---|---|
| author | Jang Hee Han Yerzhan Sharapatov Minh-Tung Do Sang Youn Kim Bogyeong Han Eue-Keun Choi Chang Wook Jeong |
| author_facet | Jang Hee Han Yerzhan Sharapatov Minh-Tung Do Sang Youn Kim Bogyeong Han Eue-Keun Choi Chang Wook Jeong |
| author_sort | Jang Hee Han |
| collection | DOAJ |
| description | This study investigated the safety and efficacy of the HyperQure™ extravascular renal denervation (RDN) system in a swine model of mild hypertension. Ten female pigs were fed a 3% salt diet to induce hypertension and underwent either extravascular RDN using the HyperQure™ RDN system (n = 7) or a sham procedure (n = 3). Blood pressure (BP) was continuously monitored using implanted transmitters, and safety assessments were conducted via computed tomography angiography (CTA) at 28 days post-procedure. The primary endpoint was the change in systolic blood pressure (SBP) at four weeks, while secondary endpoints included changes in diastolic BP (DBP), mean arterial pressure (MAP), and histological evaluation of renal nerve and artery integrity. At four weeks, SBP decreased by 11.8 ± 5.2 mmHg in the RDN group compared to an increase of 6.4 ± 4.2 mmHg in controls, resulting in a mean difference of 18.2 mmHg (p < .05). Similar improvements were observed in DBP and MAP, with mean differences of 15.4 and 16.2 mmHg, respectively (both p < .05). CTA revealed no significant renal artery or intraperitoneal organ injury. Histological analysis confirmed effective nerve ablation, as evidenced by reduced tyrosine hydroxylase staining, without intimal damage. No postoperative complications were observed during the 28-day study period. These findings demonstrate the safety and efficacy of the HyperQure™ extravascular RDN system in reducing BP, providing a promising alternative for patients with resistant hypertension or those ineligible for intravascular RDN. Further clinical trials are warranted to validate these results. |
| format | Article |
| id | doaj-art-8ce9950dce7e4ca69a29517da58ff68f |
| institution | Kabale University |
| issn | 1064-1963 1525-6006 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj-art-8ce9950dce7e4ca69a29517da58ff68f2025-08-20T03:48:15ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062025-12-0147110.1080/10641963.2025.2474520Safety and efficacy of extravascular renal denervation using HyperQure™ renal denervation system in short-term swine model of hypertensionJang Hee Han0Yerzhan Sharapatov1Minh-Tung Do2Sang Youn Kim3Bogyeong Han4Eue-Keun Choi5Chang Wook Jeong6Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Urology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Urology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South KoreaDivision of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South KoreaDepartment of Urology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South KoreaThis study investigated the safety and efficacy of the HyperQure™ extravascular renal denervation (RDN) system in a swine model of mild hypertension. Ten female pigs were fed a 3% salt diet to induce hypertension and underwent either extravascular RDN using the HyperQure™ RDN system (n = 7) or a sham procedure (n = 3). Blood pressure (BP) was continuously monitored using implanted transmitters, and safety assessments were conducted via computed tomography angiography (CTA) at 28 days post-procedure. The primary endpoint was the change in systolic blood pressure (SBP) at four weeks, while secondary endpoints included changes in diastolic BP (DBP), mean arterial pressure (MAP), and histological evaluation of renal nerve and artery integrity. At four weeks, SBP decreased by 11.8 ± 5.2 mmHg in the RDN group compared to an increase of 6.4 ± 4.2 mmHg in controls, resulting in a mean difference of 18.2 mmHg (p < .05). Similar improvements were observed in DBP and MAP, with mean differences of 15.4 and 16.2 mmHg, respectively (both p < .05). CTA revealed no significant renal artery or intraperitoneal organ injury. Histological analysis confirmed effective nerve ablation, as evidenced by reduced tyrosine hydroxylase staining, without intimal damage. No postoperative complications were observed during the 28-day study period. These findings demonstrate the safety and efficacy of the HyperQure™ extravascular RDN system in reducing BP, providing a promising alternative for patients with resistant hypertension or those ineligible for intravascular RDN. Further clinical trials are warranted to validate these results.https://www.tandfonline.com/doi/10.1080/10641963.2025.2474520Blood pressuredenervationhypertensionlaparoscopy |
| spellingShingle | Jang Hee Han Yerzhan Sharapatov Minh-Tung Do Sang Youn Kim Bogyeong Han Eue-Keun Choi Chang Wook Jeong Safety and efficacy of extravascular renal denervation using HyperQure™ renal denervation system in short-term swine model of hypertension Clinical and Experimental Hypertension Blood pressure denervation hypertension laparoscopy |
| title | Safety and efficacy of extravascular renal denervation using HyperQure™ renal denervation system in short-term swine model of hypertension |
| title_full | Safety and efficacy of extravascular renal denervation using HyperQure™ renal denervation system in short-term swine model of hypertension |
| title_fullStr | Safety and efficacy of extravascular renal denervation using HyperQure™ renal denervation system in short-term swine model of hypertension |
| title_full_unstemmed | Safety and efficacy of extravascular renal denervation using HyperQure™ renal denervation system in short-term swine model of hypertension |
| title_short | Safety and efficacy of extravascular renal denervation using HyperQure™ renal denervation system in short-term swine model of hypertension |
| title_sort | safety and efficacy of extravascular renal denervation using hyperqure™ renal denervation system in short term swine model of hypertension |
| topic | Blood pressure denervation hypertension laparoscopy |
| url | https://www.tandfonline.com/doi/10.1080/10641963.2025.2474520 |
| work_keys_str_mv | AT jangheehan safetyandefficacyofextravascularrenaldenervationusinghyperqurerenaldenervationsysteminshorttermswinemodelofhypertension AT yerzhansharapatov safetyandefficacyofextravascularrenaldenervationusinghyperqurerenaldenervationsysteminshorttermswinemodelofhypertension AT minhtungdo safetyandefficacyofextravascularrenaldenervationusinghyperqurerenaldenervationsysteminshorttermswinemodelofhypertension AT sangyounkim safetyandefficacyofextravascularrenaldenervationusinghyperqurerenaldenervationsysteminshorttermswinemodelofhypertension AT bogyeonghan safetyandefficacyofextravascularrenaldenervationusinghyperqurerenaldenervationsysteminshorttermswinemodelofhypertension AT euekeunchoi safetyandefficacyofextravascularrenaldenervationusinghyperqurerenaldenervationsysteminshorttermswinemodelofhypertension AT changwookjeong safetyandefficacyofextravascularrenaldenervationusinghyperqurerenaldenervationsysteminshorttermswinemodelofhypertension |