Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats
It has been recognized that sodium hydrogen exchanger 1 (NHE1) is involved in the development of diabetic nephropathy. The role of NHE1 in kidney dysfunction induced by advanced glycation end products (AGEs) remains unknown. Renal damage was induced by AGEs via tail vein injections in rats. Function...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1802036 |
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| author | Peng Li Geng-Rong Chen Fu Wang Ping Xu Li-Ying Liu Ya-Ling Yin Shuang-Xi Wang |
| author_facet | Peng Li Geng-Rong Chen Fu Wang Ping Xu Li-Ying Liu Ya-Ling Yin Shuang-Xi Wang |
| author_sort | Peng Li |
| collection | DOAJ |
| description | It has been recognized that sodium hydrogen exchanger 1 (NHE1) is involved in the development of diabetic nephropathy. The role of NHE1 in kidney dysfunction induced by advanced glycation end products (AGEs) remains unknown. Renal damage was induced by AGEs via tail vein injections in rats. Function and morphology of kidney were determined. Compared to vehicle- or BSA-treated rats, AGEs caused abnormalities of kidney structures and functions in rats, accompanied with higher MDA level and lower GSH content. Gene expressions of NHE1 gene and TGF-β1 in the renal cortex and urine were also increased in AGEs-injected rats. Importantly, all these detrimental effects induced by AGEs were reversed by inhibition of NHE1 or suppression of oxidative stress. These pieces of data demonstrated that AGEs may activate NHE1 to induce renal damage, which is related to TGF-β1. |
| format | Article |
| id | doaj-art-8ce6671500dc42fa8a03aa49425c53e6 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-8ce6671500dc42fa8a03aa49425c53e62025-08-20T03:37:44ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/18020361802036Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in RatsPeng Li0Geng-Rong Chen1Fu Wang2Ping Xu3Li-Ying Liu4Ya-Ling Yin5Shuang-Xi Wang6College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, ChinaDepartment of Pharmacology, Pharmaceutical College, Central South University, Changsha 410078, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, School of Medicine, Shandong University, Jinan 250012, ChinaCollege of Pharmacy, Xinxiang Medical University, Xinxiang 453003, ChinaDepartment of Pharmacology, Pharmaceutical College, Central South University, Changsha 410078, ChinaCollege of Pharmacy, Xinxiang Medical University, Xinxiang 453003, ChinaCollege of Pharmacy, Xinxiang Medical University, Xinxiang 453003, ChinaIt has been recognized that sodium hydrogen exchanger 1 (NHE1) is involved in the development of diabetic nephropathy. The role of NHE1 in kidney dysfunction induced by advanced glycation end products (AGEs) remains unknown. Renal damage was induced by AGEs via tail vein injections in rats. Function and morphology of kidney were determined. Compared to vehicle- or BSA-treated rats, AGEs caused abnormalities of kidney structures and functions in rats, accompanied with higher MDA level and lower GSH content. Gene expressions of NHE1 gene and TGF-β1 in the renal cortex and urine were also increased in AGEs-injected rats. Importantly, all these detrimental effects induced by AGEs were reversed by inhibition of NHE1 or suppression of oxidative stress. These pieces of data demonstrated that AGEs may activate NHE1 to induce renal damage, which is related to TGF-β1.http://dx.doi.org/10.1155/2016/1802036 |
| spellingShingle | Peng Li Geng-Rong Chen Fu Wang Ping Xu Li-Ying Liu Ya-Ling Yin Shuang-Xi Wang Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats Journal of Diabetes Research |
| title | Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats |
| title_full | Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats |
| title_fullStr | Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats |
| title_full_unstemmed | Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats |
| title_short | Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats |
| title_sort | inhibition of na h exchanger 1 attenuates renal dysfunction induced by advanced glycation end products in rats |
| url | http://dx.doi.org/10.1155/2016/1802036 |
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