Immunomodulatory effects of ulinastatin combined with continuous blood purification in sepsis: a systematic review and meta-analysis

Immunomodulatory effects of ulinastatin combined with continuous blood purification in sepsis: a systematic review and meta-analysis

BackgroundSepsis involves a dysregulated immune response to infection, causing inflammation and organ dysfunction. This systematic review and meta-analysis evaluated the immunomodulatory effects of ulinastatin combined with continuous blood purification (CBP) in sepsis.MethodsThis study involved a l...

Full description

Saved in:

Bibliographic Details
Main Authors:	Hui Gao, Zhiqiang Tang, Shucheng Zhao, Yuanjun Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Pharmacology
Subjects:	ulinastatin continuous blood purification sepsis inflammatory markers meta-analysis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1591470/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The impact of ulinastatin on lymphocyte apoptosis and autophagy in sepsis patients
by: Dexin Zhang, et al.
Published: (2024-11-01)

The Effect of Hybrid Blood Purification Combined with Ulinastatin for the Treatment of Severe Sepsis on APACHE II Score and Levels of miR-146a and miR-155
by: Wang K, et al.
Published: (2024-12-01)

Effect of ulinastatin on oxidative stress and intestinal flora in rats with sepsis-induced acute lung injury
by: ZHANG Yiren*, CHEN Mengxiao, LI Xiang, YU Xiangyou, WANG Yi
Published: (2024-11-01)

Effects of ulinastatin on therapeutic outcomes and inflammatory markers in pediatric septic shock patients
by: Shan Gao, et al.
Published: (2025-05-01)

Identification of common core genes and pathways in childhood sepsis and cancer by bioinformatics analysis
by: Yi-Ran He, et al.
Published: (2024-12-01)

Ulinastatin modulates TRPM4 expression and apoptosis to mitigate cognitive dysfunction in aged perioperative neurocognitive disorder rats
by: Xiaohui Xia, et al.
Published: (2025-05-01)

IMMUNOMODULATION, IMMUNOSTIMULATION AND EXTRACORPOREAL BLOOD PURIFICATION IN SEPSIS: POTENTIALLY BENEFICIAL TECHNIQUES IN CARDIAC SURGERY
by: P. Gianluca, et al.
Published: (2019-05-01)

Efficacy of Ulinastatin in the Treatment of COVID-19: A Retrospective Study
by: Liu P, et al.
Published: (2024-12-01)

Clinical efficacy of ulinastatin in the treatment of unliquefied pyogenic liver abscess complicated by septic shock: A randomized controlled trial
by: Mingfeng Guo, et al.
Published: (2023-04-01)

The effect of glucocorticoids combined with ulinastatin on IL⁃6/IL⁃10 balance and oxygenation index in patients with early acute lung injury after trauma
by: LI Tang，WANG Yudong，LI Wenchao
Published: (2025-08-01)

Ulinastatin inhibits macrophage M1 polarization to improve acute pancreatitis-associated intestinal barrier dysfunction by promoting Nrf2 signaling pathway activation
by: Qi Wang, et al.
Published: (2025-07-01)

Haemoadsorption to remove inflammatory mediators in sepsis: past, present, and future
by: Nicole J. B. Waalders, et al.
Published: (2025-03-01)

Efficient continuous-flow separation and purification processes of 5-hydroxymethylfurfural
by: Tiprawee Tongtummachat, et al.
Published: (2024-11-01)

Effect of blood lactate clearance rate on the prognosis of sepsis patients undergoing continuous renal replacement therapy
by: SUN Qin*, YAO Zhiyuan, XIA Wenfang
Published: (2024-11-01)

Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal Sepsis
by: Preslava Gatseva, et al.
Published: (2023-12-01)

Continuous Renal Replacement Therapy Using Membranes with Increased Adsorption Capacity in Patients with Septic Shock after Neurosurgical Interventions
by: А. I. Burov, et al.
Published: (2022-01-01)

Therapeutic efficacy of different models of blood purification technology for liver failure
by: Pan Hao, et al.
Published: (2021-01-01)

Extracorporeal therapies in sepsis: a comprehensive review of the Selective Cytopheretic Device, Polymyxin B and Seraph cartridges
by: Lucas Yessayan, et al.
Published: (2025-12-01)

How to prevent the infection of the novel coronavirus (2019-nCoV) in pediatric blood purification center
by: WANG Mo, et al.
Published: (2020-01-01)

Effect of continuous renal replacement therapy on serum levels of inflammatory cytokines/interleukin-17 in severe acute pancreatitis
by: Diana Iosif, et al.
Published: (2024-04-01)

Presepsin as a sepsis biomarker
by: K. A. Trunova
Published: (2018-05-01)

Consensus for Blood Purification Therapy Based on Pharmacokinetics in Acute Poisoning from Commonly Used Clinical Drugs
by: Expert Group on the Consensus for Blood Purification Therapy Based on Pharmacokinetics in Acute Poisoning from Commonly Used Clinical Drugs
Published: (2025-03-01)

Clinical application of hemoperfusion therapy combined with continuous venovenous hemofiltration in patients with sepsis
by: LUO Jian-yu, et al.
Published: (2019-01-01)

Risk factors for catheter-related infection of non-cuffed femoral vein catheter in blood purification therapy patients
by: 安娜, et al.
Published: (2020-01-01)

Construction of a system for isolation and purification of NK cells from whole blood donations
by: CAO Tengyu, et al.
Published: (2025-02-01)

Nursing of a neonate with multiple organ dysfunction syndrome treated by blood purification (血液净化治疗新生儿多器官功能障碍1例的护理体会)
by: LIN Dongying (林东莹), et al.
Published: (2022-08-01)

Curative effect of different blood purification methods for uremic pruritus and their effects on the patients’ life quality
by: ZHONG Guang-zhi, et al.
Published: (2016-01-01)

Clinical and Economic Evaluation of the Blood Purification with Selective Sorption Techniques in ICU Patients
by: Yu. S. Polushin, et al.
Published: (2023-02-01)

Microwave‐assisted Synthesis of Poly(methacrylic acid) Particles for Blood Purification
by: Farbod Alimohammadi, et al.
Published: (2025-03-01)

A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis
by: T. N. Shruthi, et al.
Published: (2025-01-01)

Alpha-1-microglobulin profile in patients on maintenance hemodialysis and its removal by blood purification
by: Tadashi Tomo, et al.
Published: (2025-12-01)

Continuous vs. intermittent meropenem infusion in critically ill patients with sepsis: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
by: Youquan Wang, et al.
Published: (2025-06-01)

Comparison of the diagnostic accuracy of resistin and CRP levels for sepsis in neonates and children: a systematic review and meta-analysis
by: Fen Xu, et al.
Published: (2025-05-01)

Clinical Efficacy of Continuous Renal Replacement Therapy in Patients with Pulmonary Tuberculosis Complicated with Sepsis: A Retrospective Observational Study
by: Chen X, et al.
Published: (2025-04-01)

Analysis of the mediating effect of social status perception on professional identity and work engagement of blood purification nurses
by: Jia Wanning, et al.
Published: (2024-12-01)

Attenuation of acute kidney injury in a murine model of neonatal Escherichia coli sepsis
by: Esther M. Speer, et al.
Published: (2025-02-01)

Analysis of prognosis and influencing factors of sepsis patients receiving blood component transfusion
by: ZHAO Bingjie, et al.
Published: (2025-07-01)

Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy
by: Qian Sun, et al.
Published: (2025-07-01)

Presepsin as a diagnostic biomarker for sepsis across neonates, children, and adults: A meta-analysis
by: Kaicheng Peng, et al.
Published: (2025-08-01)

HA380 Hemoperfusion Combined with Continuous Veno-Venous Hemodiafiltration for the Treatment of Septic Shock
by: Yuling An, et al.
Published: (2025-04-01)