Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer
Advanced gastric cancer with bone metastasis has a very poor prognosis with short median survival. To the best of our knowledge, no reports in literature have described extensive recovery of paralysis with multimodality treatment without surgery in these cases. This report describes the case of a 52...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/2020/4753027 |
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| author | Hideyuki Kinoshita Hiroto Kamoda Takeshi Ishii Yoko Hagiwara Toshinori Tsukanishi Yusuke Amanuma Rino Nankinzan Sumihisa Orita Kazuhide Inage Naoya Hirosawa Seiji Ohtori Tsukasa Yonemoto |
| author_facet | Hideyuki Kinoshita Hiroto Kamoda Takeshi Ishii Yoko Hagiwara Toshinori Tsukanishi Yusuke Amanuma Rino Nankinzan Sumihisa Orita Kazuhide Inage Naoya Hirosawa Seiji Ohtori Tsukasa Yonemoto |
| author_sort | Hideyuki Kinoshita |
| collection | DOAJ |
| description | Advanced gastric cancer with bone metastasis has a very poor prognosis with short median survival. To the best of our knowledge, no reports in literature have described extensive recovery of paralysis with multimodality treatment without surgery in these cases. This report describes the case of a 52-year-old severely paralyzed female patient with spinal metastasis from advanced gastric cancer. She was inoperable, owing to a large thrombus in the inferior vena cava; alternative multimodality treatments, including chemotherapy and radiotherapy, were administered. The paralysis and the bladder and rectal dysfunction improved considerably. In addition, the performance status (PS) and Frankel grade also improved dramatically, from 4 to 1 and grade B to D, respectively. At 1 year after initiation of treatment, she is ambulatory. Patients with poor PS are often offered palliative therapy. However, this case demonstrates that poor PS solely due to paralysis from spinal metastasis may necessitate multimodality treatment instead of palliative care. |
| format | Article |
| id | doaj-art-8ce58cd16d0347058b326f2e34208198 |
| institution | Kabale University |
| issn | 2090-6749 2090-6757 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Orthopedics |
| spelling | doaj-art-8ce58cd16d0347058b326f2e342081982025-02-03T06:46:05ZengWileyCase Reports in Orthopedics2090-67492090-67572020-01-01202010.1155/2020/47530274753027Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric CancerHideyuki Kinoshita0Hiroto Kamoda1Takeshi Ishii2Yoko Hagiwara3Toshinori Tsukanishi4Yusuke Amanuma5Rino Nankinzan6Sumihisa Orita7Kazuhide Inage8Naoya Hirosawa9Seiji Ohtori10Tsukasa Yonemoto11Department of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, JapanDepartment of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, JapanDepartment of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, JapanDepartment of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, JapanDepartment of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, JapanDepartment of Gastroenterology, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, JapanDepartment of Endoscopy, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, JapanAdvanced gastric cancer with bone metastasis has a very poor prognosis with short median survival. To the best of our knowledge, no reports in literature have described extensive recovery of paralysis with multimodality treatment without surgery in these cases. This report describes the case of a 52-year-old severely paralyzed female patient with spinal metastasis from advanced gastric cancer. She was inoperable, owing to a large thrombus in the inferior vena cava; alternative multimodality treatments, including chemotherapy and radiotherapy, were administered. The paralysis and the bladder and rectal dysfunction improved considerably. In addition, the performance status (PS) and Frankel grade also improved dramatically, from 4 to 1 and grade B to D, respectively. At 1 year after initiation of treatment, she is ambulatory. Patients with poor PS are often offered palliative therapy. However, this case demonstrates that poor PS solely due to paralysis from spinal metastasis may necessitate multimodality treatment instead of palliative care.http://dx.doi.org/10.1155/2020/4753027 |
| spellingShingle | Hideyuki Kinoshita Hiroto Kamoda Takeshi Ishii Yoko Hagiwara Toshinori Tsukanishi Yusuke Amanuma Rino Nankinzan Sumihisa Orita Kazuhide Inage Naoya Hirosawa Seiji Ohtori Tsukasa Yonemoto Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer Case Reports in Orthopedics |
| title | Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer |
| title_full | Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer |
| title_fullStr | Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer |
| title_full_unstemmed | Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer |
| title_short | Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer |
| title_sort | successful neurological recovery with multimodality therapy without surgery for spinal metastases from advanced gastric cancer |
| url | http://dx.doi.org/10.1155/2020/4753027 |
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