Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review
Ochratoxin A (OTA) is a mycotoxin with different adverse health effects. The authors conducted a systematic review to evaluate the effects of OTA on the immune system, with more emphasis on its effects on immune system organs, innate and adaptive immunity and related signaling pathways. Studies have...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/17/5/256 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849327105464074240 |
|---|---|
| author | Yusif Mubarik Shadrach Tetteh Boyetey Anastasia Rosebud Aikins Mohamed Mutocheluh |
| author_facet | Yusif Mubarik Shadrach Tetteh Boyetey Anastasia Rosebud Aikins Mohamed Mutocheluh |
| author_sort | Yusif Mubarik |
| collection | DOAJ |
| description | Ochratoxin A (OTA) is a mycotoxin with different adverse health effects. The authors conducted a systematic review to evaluate the effects of OTA on the immune system, with more emphasis on its effects on immune system organs, innate and adaptive immunity and related signaling pathways. Studies have demonstrated that exposure to OTA disrupts the functions of immune system organs, resulting in weight loss, histological lesions and a decrease in antibody-secreting cells. There is evidence that OTA impairs epithelial barrier integrity and macrophage function and induces elevated secretion of pro-inflammatory cytokines. In adaptive immunity, OTA regulates T-cell differentiation, particularly Th1 and Th17 subsets, and adversely impacts humoral immunity, ultimately leading to immune suppression. |
| format | Article |
| id | doaj-art-8ce2dee9fbb54ab1b6a0913e2df24997 |
| institution | Kabale University |
| issn | 2072-6651 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj-art-8ce2dee9fbb54ab1b6a0913e2df249972025-08-20T03:47:58ZengMDPI AGToxins2072-66512025-05-0117525610.3390/toxins17050256Effect of Ochratoxin A (OTA) on the Immune System: A Systematic ReviewYusif Mubarik0Shadrach Tetteh Boyetey1Anastasia Rosebud Aikins2Mohamed Mutocheluh3West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Greater Accra, Accra P.O. Box LG 54, GhanaSchool of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi P.O. Box 256, GhanaWest African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Greater Accra, Accra P.O. Box LG 54, GhanaDepartment of Clinical Microbiology, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi P.O. Box 256, GhanaOchratoxin A (OTA) is a mycotoxin with different adverse health effects. The authors conducted a systematic review to evaluate the effects of OTA on the immune system, with more emphasis on its effects on immune system organs, innate and adaptive immunity and related signaling pathways. Studies have demonstrated that exposure to OTA disrupts the functions of immune system organs, resulting in weight loss, histological lesions and a decrease in antibody-secreting cells. There is evidence that OTA impairs epithelial barrier integrity and macrophage function and induces elevated secretion of pro-inflammatory cytokines. In adaptive immunity, OTA regulates T-cell differentiation, particularly Th1 and Th17 subsets, and adversely impacts humoral immunity, ultimately leading to immune suppression.https://www.mdpi.com/2072-6651/17/5/256ochratoxin A (OTA)innateadaptiveimmunity |
| spellingShingle | Yusif Mubarik Shadrach Tetteh Boyetey Anastasia Rosebud Aikins Mohamed Mutocheluh Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review Toxins ochratoxin A (OTA) innate adaptive immunity |
| title | Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review |
| title_full | Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review |
| title_fullStr | Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review |
| title_full_unstemmed | Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review |
| title_short | Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review |
| title_sort | effect of ochratoxin a ota on the immune system a systematic review |
| topic | ochratoxin A (OTA) innate adaptive immunity |
| url | https://www.mdpi.com/2072-6651/17/5/256 |
| work_keys_str_mv | AT yusifmubarik effectofochratoxinaotaontheimmunesystemasystematicreview AT shadrachtettehboyetey effectofochratoxinaotaontheimmunesystemasystematicreview AT anastasiarosebudaikins effectofochratoxinaotaontheimmunesystemasystematicreview AT mohamedmutocheluh effectofochratoxinaotaontheimmunesystemasystematicreview |