The role of air pollution in epilepsy: a better understanding is needed

Social determinants of health, including neighborhood and built environment factors, play a crucial but underexplored role in epilepsy incidences. Among these, air pollution emerges as a potentially-preventable driver of epilepsy and adverse health outcomes. Evidence is accumulating on the effects o...

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Main Authors: Prem Jareonsettasin, John S. Ji, Xiaowen Zhou, Ding Ding, Josemir W. Sander, on behalf of the SdHIELD (Social determinants of Health In EpiLeptic Disorders) Research Group
Format: Article
Language:English
Published: Thieme Revinter Publicações 2025-06-01
Series:Arquivos de Neuro-Psiquiatria
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Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1809663
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author Prem Jareonsettasin
John S. Ji
Xiaowen Zhou
Ding Ding
Josemir W. Sander
on behalf of the SdHIELD (Social determinants of Health In EpiLeptic Disorders) Research Group
author_facet Prem Jareonsettasin
John S. Ji
Xiaowen Zhou
Ding Ding
Josemir W. Sander
on behalf of the SdHIELD (Social determinants of Health In EpiLeptic Disorders) Research Group
author_sort Prem Jareonsettasin
collection DOAJ
description Social determinants of health, including neighborhood and built environment factors, play a crucial but underexplored role in epilepsy incidences. Among these, air pollution emerges as a potentially-preventable driver of epilepsy and adverse health outcomes. Evidence is accumulating on the effects of air pollution on the brain, especially in stroke and neurodegenerative disorders; however, the specific impact on epilepsy remains underresearched, potentially due to the complexities of studying this condition. The present narrative review addresses a critical knowledge gap by exploring: 1) the role of air pollution in epilepsy epidemiology; 2) the biological mechanisms of air pollution in the brain in the context of epilepsy; and 3) how air pollution affects the management of people living with epilepsy. We outline vital questions and actionable interventions regarding the role of air pollution in epilepsy.
format Article
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institution OA Journals
issn 0004-282X
1678-4227
language English
publishDate 2025-06-01
publisher Thieme Revinter Publicações
record_format Article
series Arquivos de Neuro-Psiquiatria
spelling doaj-art-8ce20d58dc2f475786aaa2f21257129a2025-08-20T02:38:29ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42272025-06-01830600101210.1055/s-0045-1809663The role of air pollution in epilepsy: a better understanding is neededPrem Jareonsettasin0https://orcid.org/0000-0003-3740-4001John S. Ji1https://orcid.org/0000-0002-5002-118XXiaowen Zhou2https://orcid.org/0009-0002-9775-8549Ding Ding3https://orcid.org/0000-0002-3260-7515Josemir W. Sander4https://orcid.org/0000-0001-6041-9661on behalf of the SdHIELD (Social determinants of Health In EpiLeptic Disorders) Research Group5University College London (UCL), Faculty of Brain Sciences, Queen Square Institute of Neurology, London, United Kingdom.Tsinghua University, Vanke School of Public Health, Beijing, China.Fudan University, Huashan Hospital, Institute of Neurology, National Center for Neurological Disorders, National Clinical Research Center for Aging and Medicine, Shanghai, China.Fudan University, Huashan Hospital, Institute of Neurology, National Center for Neurological Disorders, National Clinical Research Center for Aging and Medicine, Shanghai, China.University College London (UCL), Faculty of Brain Sciences, Queen Square Institute of Neurology, London, United Kingdom.on behalf of the SdHIELD (Social determinants of Health In EpiLeptic Disorders) Research GroupSocial determinants of health, including neighborhood and built environment factors, play a crucial but underexplored role in epilepsy incidences. Among these, air pollution emerges as a potentially-preventable driver of epilepsy and adverse health outcomes. Evidence is accumulating on the effects of air pollution on the brain, especially in stroke and neurodegenerative disorders; however, the specific impact on epilepsy remains underresearched, potentially due to the complexities of studying this condition. The present narrative review addresses a critical knowledge gap by exploring: 1) the role of air pollution in epilepsy epidemiology; 2) the biological mechanisms of air pollution in the brain in the context of epilepsy; and 3) how air pollution affects the management of people living with epilepsy. We outline vital questions and actionable interventions regarding the role of air pollution in epilepsy.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1809663EpilepsyAir PollutionParticulate MatterSocial Determinants of HealthEpidemiology
spellingShingle Prem Jareonsettasin
John S. Ji
Xiaowen Zhou
Ding Ding
Josemir W. Sander
on behalf of the SdHIELD (Social determinants of Health In EpiLeptic Disorders) Research Group
The role of air pollution in epilepsy: a better understanding is needed
Arquivos de Neuro-Psiquiatria
Epilepsy
Air Pollution
Particulate Matter
Social Determinants of Health
Epidemiology
title The role of air pollution in epilepsy: a better understanding is needed
title_full The role of air pollution in epilepsy: a better understanding is needed
title_fullStr The role of air pollution in epilepsy: a better understanding is needed
title_full_unstemmed The role of air pollution in epilepsy: a better understanding is needed
title_short The role of air pollution in epilepsy: a better understanding is needed
title_sort role of air pollution in epilepsy a better understanding is needed
topic Epilepsy
Air Pollution
Particulate Matter
Social Determinants of Health
Epidemiology
url http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1809663
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