A novel scoring model for predicting prolonged mechanical ventilation in cardiac surgery patients: development and validation

ObjectiveProlonged mechanical ventilation (PMV) is a significant postoperative complication in cardiac surgery, associated with increased mortality and healthcare costs. This study aims to develop and validate a novel scoring model to predict the risk of PMV in cardiac surgery patients.MethodsA retr...

Full description

Saved in:
Bibliographic Details
Main Authors: Quan Liu, Pengfei Chen, Wuwei Wang, Yifei Zhou, Yichen Xu, Xu Cao, Rui Fan, Wen Chen, Fuhua Huang, Xin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1573874/full
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850217747115409408
author Quan Liu
Quan Liu
Pengfei Chen
Wuwei Wang
Yifei Zhou
Yifei Zhou
Yichen Xu
Xu Cao
Rui Fan
Wen Chen
Fuhua Huang
Xin Chen
Xin Chen
author_facet Quan Liu
Quan Liu
Pengfei Chen
Wuwei Wang
Yifei Zhou
Yifei Zhou
Yichen Xu
Xu Cao
Rui Fan
Wen Chen
Fuhua Huang
Xin Chen
Xin Chen
author_sort Quan Liu
collection DOAJ
description ObjectiveProlonged mechanical ventilation (PMV) is a significant postoperative complication in cardiac surgery, associated with increased mortality and healthcare costs. This study aims to develop and validate a novel scoring model to predict the risk of PMV in cardiac surgery patients.MethodsA retrospective analysis was conducted using data from 14 comprehensive hospitals in Jiangsu Province, including adult patients who underwent coronary artery bypass grafting (CABG), valve surgery, and aortic surgery from January 2021 to December 2022. Predictive variables were selected based on clinical expertise and prior literature, and a nomogram was developed using LASSO regression and multiple logistic regression. Model performance was evaluated using the C-index, calibration plots, and decision curve analysis (DCA).ResultsA total of 5,206 patients were included in the final analysis. The incidence rate of PMV were 11.83% in the training set, 8.65% in the internal validation set, and 15.4% in the external validation set. The nomogram identified 9 significant predictors, including age, gender, preoperative conditions, and surgical factors. The model demonstrated robust performance with C-index values of 0.79 in the training and internal validation sets and 0.75 in the external validation set, indicating good predictive capability. Calibration curves confirmed the accuracy of predicted probabilities, and DCA indicated substantial net benefits for clinical decision-making.ConclusionsThis study presents a validated scoring model for predicting PMV in cardiac surgery patients, integrating a comprehensive range of clinical variables. The model facilitates early identification of high-risk patients, enabling tailored perioperative strategies and potentially improving patient outcomes and resource utilization in cardiac surgery.
format Article
id doaj-art-8cd87e7a15b44460b33ec1c1cd61a74c
institution OA Journals
issn 2297-055X
language English
publishDate 2025-03-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Cardiovascular Medicine
spelling doaj-art-8cd87e7a15b44460b33ec1c1cd61a74c2025-08-20T02:07:59ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-03-011210.3389/fcvm.2025.15738741573874A novel scoring model for predicting prolonged mechanical ventilation in cardiac surgery patients: development and validationQuan Liu0Quan Liu1Pengfei Chen2Wuwei Wang3Yifei Zhou4Yifei Zhou5Yichen Xu6Xu Cao7Rui Fan8Wen Chen9Fuhua Huang10Xin Chen11Xin Chen12School of Medicine, Southeast University, Nanjing, Jiangsu, ChinaDepartment of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaCardiovascular Surgery Department, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, ChinaDepartment of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaSchool of Medicine, Southeast University, Nanjing, Jiangsu, ChinaDepartment of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaSchool of Medicine, Southeast University, Nanjing, Jiangsu, ChinaDepartment of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaObjectiveProlonged mechanical ventilation (PMV) is a significant postoperative complication in cardiac surgery, associated with increased mortality and healthcare costs. This study aims to develop and validate a novel scoring model to predict the risk of PMV in cardiac surgery patients.MethodsA retrospective analysis was conducted using data from 14 comprehensive hospitals in Jiangsu Province, including adult patients who underwent coronary artery bypass grafting (CABG), valve surgery, and aortic surgery from January 2021 to December 2022. Predictive variables were selected based on clinical expertise and prior literature, and a nomogram was developed using LASSO regression and multiple logistic regression. Model performance was evaluated using the C-index, calibration plots, and decision curve analysis (DCA).ResultsA total of 5,206 patients were included in the final analysis. The incidence rate of PMV were 11.83% in the training set, 8.65% in the internal validation set, and 15.4% in the external validation set. The nomogram identified 9 significant predictors, including age, gender, preoperative conditions, and surgical factors. The model demonstrated robust performance with C-index values of 0.79 in the training and internal validation sets and 0.75 in the external validation set, indicating good predictive capability. Calibration curves confirmed the accuracy of predicted probabilities, and DCA indicated substantial net benefits for clinical decision-making.ConclusionsThis study presents a validated scoring model for predicting PMV in cardiac surgery patients, integrating a comprehensive range of clinical variables. The model facilitates early identification of high-risk patients, enabling tailored perioperative strategies and potentially improving patient outcomes and resource utilization in cardiac surgery.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1573874/fullprolonged mechanical ventilationcardiac surgerypredicting modelmultiple centersretrospective study
spellingShingle Quan Liu
Quan Liu
Pengfei Chen
Wuwei Wang
Yifei Zhou
Yifei Zhou
Yichen Xu
Xu Cao
Rui Fan
Wen Chen
Fuhua Huang
Xin Chen
Xin Chen
A novel scoring model for predicting prolonged mechanical ventilation in cardiac surgery patients: development and validation
Frontiers in Cardiovascular Medicine
prolonged mechanical ventilation
cardiac surgery
predicting model
multiple centers
retrospective study
title A novel scoring model for predicting prolonged mechanical ventilation in cardiac surgery patients: development and validation
title_full A novel scoring model for predicting prolonged mechanical ventilation in cardiac surgery patients: development and validation
title_fullStr A novel scoring model for predicting prolonged mechanical ventilation in cardiac surgery patients: development and validation
title_full_unstemmed A novel scoring model for predicting prolonged mechanical ventilation in cardiac surgery patients: development and validation
title_short A novel scoring model for predicting prolonged mechanical ventilation in cardiac surgery patients: development and validation
title_sort novel scoring model for predicting prolonged mechanical ventilation in cardiac surgery patients development and validation
topic prolonged mechanical ventilation
cardiac surgery
predicting model
multiple centers
retrospective study
url https://www.frontiersin.org/articles/10.3389/fcvm.2025.1573874/full
work_keys_str_mv AT quanliu anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT quanliu anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT pengfeichen anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT wuweiwang anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT yifeizhou anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT yifeizhou anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT yichenxu anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT xucao anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT ruifan anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT wenchen anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT fuhuahuang anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT xinchen anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT xinchen anovelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT quanliu novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT quanliu novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT pengfeichen novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT wuweiwang novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT yifeizhou novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT yifeizhou novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT yichenxu novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT xucao novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT ruifan novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT wenchen novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT fuhuahuang novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT xinchen novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation
AT xinchen novelscoringmodelforpredictingprolongedmechanicalventilationincardiacsurgerypatientsdevelopmentandvalidation